Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing Mu, Chunxiao Li, Shi Yu, Guoyong Liu, Jianhua Zou, Dong-Yang Zhang, Chao Jiang, Xiuli Wang, Liangcan He, Peng Huang, Yuxin Yin, Xiaoyuan Chen
Summary: This study presents a novel strategy for protecting the liver against ischemia-reperfusion injury using nanotherapeutics. By combining reactive oxygen species scavenging and nitric oxide modulation, the researchers demonstrated that the nanotherapeutics effectively reduced oxidative stress and inflammation in the liver.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Yanyao Liu, Zilun Lei, Hao Chai, Song Xiang, Yihua Wang, Ping Yan, Zhenrui Cao, Xingyu Pu, Zhongjun Wu
Summary: This study found that recombinant human thrombomodulin (rTM) can inhibit the formation of neutrophil extracellular traps (NETs), alleviate hepatic ischemia-reperfusion injury (IRI) and improve liver function. rTM blocks multiple signaling pathways to inhibit NETosis. The results suggest that NETs are a potential therapeutic target for hepatic IRI and rTM can be used to prevent liver injury caused by IRI.
Article
Multidisciplinary Sciences
So Hye Yoon, Hye Bin Kang, Jongwan Kim, Keunje Yoo, Sang Jun Han
Summary: This study found that diminazene aceturate (DIZE) can protect the liver from ischemia/reperfusion (I/R) injury by attenuating inflammation and oxidative damage. DIZE treatment reduces liver failure and histologically-apparent liver damage, as well as milder inflammatory responses, reactive oxidative damage, and apoptosis following hepatic I/R.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Mohamed A. Morsy, Seham A. Abdel-Gaber, Rehab A. Rifaai, Mostafa M. Mohammed, Anroop B. Nair, Walaa Yehia Abdelzaher
Summary: Telmisartan demonstrates protective effects against hepatic I/R injury in rats by modulating oxidative stress parameters, myeloperoxidase levels, PPARγ and TLR4 mRNA expression, as well as NF-κB and caspase-3 immunoexpression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Libor Vitek
Summary: The liver has evolved defense systems to protect against harmful stimuli, including antioxidant substances and enzymes, anti-inflammatory tools, enzymatic biotransformation systems, and metabolic pathways. Recent research indicates the significant role of the heme catabolic pathway in regulating the pathogenesis of liver and other diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Immunology
Jonathan M. Harnoss, Jun Cai, Sascha Hinterkopf, Praveen Radhakrishnan, Annabelle Schmitt, Mareen Dupovac, Lisa K. Nees, Moritz J. Strowitzki, Cormac T. Taylor, Martin Schneider
Summary: This study investigates the activation of the HIF pathway through inhibition of PHDs as a potential strategy to reduce primary graft dysfunction (PGD) after liver transplantation (LT). The results show that the administration of the small-molecule inhibitor EDHB induces HIF-1 signaling and increases the expression of its downstream target genes. In vivo experiments demonstrate that pretreatment with EDHB can mitigate hepatic ischemia and reperfusion injury and allograft injury after LT in animal models. The findings suggest that targeting PHDs with small-molecule inhibitors could be a promising therapeutic approach to reduce PGD after LT.
Article
Biology
Maged E. Mohamed, Nancy S. Younis
Summary: The study found that pretreatment with D-carvone can protect the liver against damage induced by hepatic ischemia-reperfusion. D-carvone downregulates the expression of HMGB1, TLR4, NF kappa B, and NLP3, leading to a reduction in adhesion molecules, neutrophil infiltration, inflammatory mediators, and apoptotic markers.
Article
Reproductive Biology
Vahid Ganjiani, Nasrollah Ahmadi, Mohammad Reza Divar, Hassan Sharifiyazdi, Abdolhamid Meimandi-Parizi
Summary: The study revealed that I/R injury significantly affects sperm parameters, but crocin treatment did not significantly improve them. Crocin significantly improved histopathological parameters and hormone levels, reversing oxidative stress injuries caused by torsion/detorsion.
Article
Pharmacology & Pharmacy
C. Durgun, F. Asir
Summary: The study aimed to investigate the potential protective effect of Ellagic Acid on hepatic ischemia-reperfusion injury in rats. The results showed that Ellagic Acid may reduce oxidative stress levels, prevent inflammation, and decrease cell death in hepatic ischemia-reperfusion.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Editorial Material
Medicine, Research & Experimental
Renzo Boldorini, Nausicaa Clemente, Elisa Alchera, Rita Carini
Summary: Ischemia-reperfusion injury (IRI) following major liver surgery remains a challenging clinical problem. Activation of the endogenous hepatoprotection systems, such as through 'ischemic preconditioning', can mitigate the damaging effects of IRI. Recent research has identified a novel protective molecule, DUSP12, which shows promise as a therapeutic target for preventing hepatic IRI by inhibiting the ASK1/JNK-p38 MAPK pathway.
Article
Medicine, Research & Experimental
Zexin Li, Ying Wang, Yu Zhang, Xiao Wang, Baoqin Gao, Yan Li, Rong Li, Jianguo Wang
Summary: Fisetin was found to alleviate liver damage, cell apoptosis, and oxidative stress induced by liver IRI, at least through the Nrf2/HO-1 signaling pathway, suggesting its potential as a targeted drug for liver IRI treatment.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
C. Dogru, F. Asir
Summary: This study aimed to investigate the potential protective effect of Ellagic Acid on damage caused by hepatic ischemia-reperfusion in rats. The results showed that Ellagic Acid can reduce oxidative stress level and prevent induction of inflammation and cell death.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Yinzhi Deng, Hesheng Luo
Summary: Through screening and analysis of gene expression data, we identified phosphoserine aminotransferase 1 (PSAT1) as a potential gene for hepatic ischemia-reperfusion (I/R) injury. Further experiments confirmed the crucial role of PSAT1 in alleviating hepatic I/R injury.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
