Article
Obstetrics & Gynecology
Elise O. R. Kearsey, Jasper Been, Vivienne L. Souter, Sarah J. Stock
Summary: This study examined the impact of the publication of the Antenatal Late Preterm Steroids study on the rates of antenatal corticosteroid therapy administration in late preterm births in the United States. The results showed a significant increase in the rates of antenatal corticosteroid therapy administration in late preterm births and full-term births following the online publication of the study. However, this also resulted in an unnecessary increase in the number of full-term infants receiving antenatal corticosteroid therapy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Nuran Ustun, Sertac Arslanoglu, Fahri Ovali
Summary: In very low birth weight infants, complete antenatal steroids exposure may be associated with improved renal function and decreased risk for acute kidney injury compared with no antenatal steroids.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Charlotte Humbeck, Sinje Jonassen, Arne Bringewatt, Mascha Pervan, Achim Rody, Verena Bossung
Summary: This study evaluated the timing of antenatal steroid administration in pregnant women with imminent preterm birth. The results showed that most women did not give birth within 7 days after receiving antenatal steroids. The timing was optimal for preterm birth due to certain conditions such as preeclampsia, PPROM, and FGR. The study suggests that antenatal steroids should be used more restrictively to improve neonatal outcomes and reduce unnecessary interventions.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Nutrition & Dietetics
Silvia Martini, Mariarosaria Annunziata, Anna Nunzia Della Gatta, Arianna Aceti, Marica Brunetti, Gianluigi Pilu, Giuliana Simonazzi, Luigi Corvaglia
Summary: Antenatal Doppler abnormalities are associated with increased gastrointestinal risks in preterm infants. Detailed knowledge of Doppler features can help identify patients at highest risk of intestinal complications, who may benefit from tailored enteral feeding management.
Article
Obstetrics & Gynecology
Jessica Smith, Kellie E. Murphy, Sarah D. McDonald, Elizabeth Asztalos, Amir Aviram, Stefania Ronzoni, Elad Mei-Dan, Arthur Zaltz, Jon Barrett, Nir Melamed
Summary: This study aimed to determine the proportion of women who receive antenatal corticosteroids (ACS) within the optimal time window before birth based on the indication for ACS. Results showed that over two-thirds of infants do not receive the maximal benefit from ACS, and identified clinical indications associated with suboptimal timing.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Pediatrics
Jeffrey B. Gould, Mihoko Bennett, Ciaran S. Phibbs, Henry C. Lee
Summary: As the use of antenatal steroids in the population increased, so did the observed positive effects of antenatal steroids. Women who did not receive antenatal steroids had a higher risk profile and predicted probability for severe IVH and mortality. In women who received antenatal steroids, both observed and adjusted rates for the outcomes decreased.
JOURNAL OF PEDIATRICS
(2021)
Review
Hematology
Luise Bellach, Michael Eigenschink, Abtin Hassanein, Danylo Savran, Ulrich Salzer, Ernst W. Muellner, Andreas Repa, Katrin Klebermass-Schrehof, Lukas Wisgrill, Vito Giordano, Angelika Berger
Summary: Transfusion of adult packed red blood cells (pRBCs) into preterm infants may be inappropriate due to differences in erythrocytes. Lack of standardisation in transfusion protocols and differences in study designs hinder the interpretation of clinical data.
LANCET HAEMATOLOGY
(2022)
Review
Pediatrics
Akira Kobayashi, Masato Ito, Erika Ota, Fumihiko Namba
Summary: Antenatal magnesium sulphate therapy may not affect the neurological outcomes of preterm infants at school-age, including cerebral palsy, hearing impairment, neurosensory disability, and death. However, the impact on mental retardation and visual impairment remains uncertain. Antenatal magnesium sulphate therapy may increase the risk of maternal adverse events, but is not associated with neonatal symptoms.
Article
Medicine, Research & Experimental
Patrick Morhart, Janis Gaertner, Christel Weiss, Florian Matthias Stumpfe, Ulf Dammer, Florian Faschingbauer, Fabian B. Fahlbusch, Matthias W. Beckmann, Sven Kehl
Summary: Administration of antenatal corticosteroids within 7 days before birth significantly reduces the risk of respiratory distress syndrome and intraventricular hemorrhage in preterm infants.
Article
Pediatrics
Lisa Letzkus, Robin Picavia, Genevieve Lyons, Jackson Brandberg, Jiaxing Qiu, Sherry Kausch, Doug Lake, Karen Fairchild
Summary: This study used highly comparative time series analysis to discover novel heart rate characteristics predicting cerebral palsy in preterm infants. The researchers found that low variability in heart rate during the first week after birth and a pattern of recurrent acceleration in heart rate at term corrected age were predictive of cerebral palsy. A combination of clinical and early and late heart rate features had a high predictive value for cerebral palsy.
PEDIATRIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Takafumi Ushida, Yoshinori Moriyama, Masahiro Nakatochi, Yumiko Kobayashi, Kenji Imai, Tomoko Nakano-Kobayashi, Noriyuki Nakamura, Masahiro Hayakawa, Hiroaki Kajiyama, Tomomi Kotani
Summary: The study aimed to predict adverse outcomes in extremely preterm infants based on antenatal maternal and fetal factors, developing prediction models for short-term and medium-term outcomes. Results showed good discriminative ability for certain outcomes, providing a valuable bedside prediction tool for clinicians and facilitating risk-stratified perinatal management.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Ashley N. Battarbee, Yuanfan Ye, Jeff M. Szychowski, Brian M. Casey, Alan T. Tita, Kim A. Boggess
Summary: Maternal glycemic control after late preterm steroid administration does not improve fetal metabolic status or decrease the risk of neonatal hypoglycemia.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Obstetrics & Gynecology
Eliza R. McElwee, Kyla Wilkinson, Rebecca Crowe, Jill C. Newman, Mallory Alkis, Rebecca Wineland, Matthew M. Finneran
Summary: This study found that over one-third of women received late preterm ACS for indications that could be classified as indication creep, and inappropriate administration was associated with higher rates of nonoptimal exposure.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Review
Immunology
Donna Lei, Taryn Miller, Jeremy Carr, Jim Buttery, Claudia A. Nold-Petry, Marcel F. Nold, Atul Malhotra
Summary: Existing guidelines on the timing of the first dose of hepatitis B vaccine in preterm infants vary significantly between countries and regions. Further research is needed to compare the immunogenicity and safety of different vaccination schedules.
Review
Pediatrics
Emily B. Sarid, Michelle L. Stoopler, Anne-Maude Morency, Jarred Garfinkle
Summary: This study aims to summarize the association between antenatal corticosteroids (ACS) exposure for the risk of preterm birth and brain development in infants born late preterm and at term. The majority of studies suggest that ACS exposure is associated with adverse brain development outcomes in late preterm and term infants, including reduced neonatal head circumference, cortical differences on MRI, increased prevalence of psychiatric problems, and neurodevelopmental delays.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Satyan Lakshminrusimha, Ola D. Saugstad, Maximo Vento
JOURNAL OF PEDIATRICS
(2023)
Correction
Obstetrics & Gynecology
Nancy A. Rodriguez, Fernando Moya, John Ladino, Adel Zauk, Preetha Prazad, Jorge Perez, Maximo Vento, Erika Claud, Chi-hsiung Wang, Michael S. Caplan
JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Nancy A. A. Rodriguez, Fernando Moya, John Landino, Adel Zauk, Preetha Prazad, Jorge Perez, Maximo Vento, Erika Claud, Chi-hsiung Wang, Michael S. Caplan
Summary: Oropharyngeal therapy with mother's own milk (OPT-MOM) did not reduce late-onset sepsis (L-OS), necrotizing enterocolitis (NEC) or death in preterm infants. However, there was a trend towards reduced length of stay and improved nutritional outcomes in the group receiving OPT-MOM.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Mari Merce Cascant-Vilaplana, Inmaculada Lara-Canton, Antonio Nunez-Ramiro, Alvaro Solaz-Garcia, Roberto Llorens-Salvador, Guillermo Quintas, Julia Kuligowski, Maximo Vento
Summary: In this study, researchers analyzed plasma samples from newborns using nuclear magnetic resonance (NMR) spectroscopy and found that lactate and other substances can discern the degree of brain injury. This is the first longitudinal study on infants with hypoxic-ischemic encephalopathy, and the measurement of lactate confirms its reliability as a biomarker for predicting the severity of brain injury.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Niklas Breindahl, Martin G. Tolsgaard, Tine B. Henriksen, Charles C. Roehr, Tomasz Szczapa, Luigi Gagliardi, Maximo Vento, Ragnhild Stoen, Kajsa Bohlin, Anton H. van Kaam, Daniel Klotz, Xavier Durrmeyer, Tongyan Han, Anup C. Katheria, Peter A. Dargaville, Lise Aunsholt
Summary: This study established an international consensus on the training curriculum and assessment tool for the less invasive surfactant administration procedure (LISA). The consensus-based expert statement provides content that can optimize and standardize LISA training in the future.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Thomas M. Raffay, Juliann M. Di Fiore, Zhengyi Chen, Angel Sanchez-Illana, Maximo Vento, Jose David Pineiro-Ramos, Julia Kuligowski, Richard J. Martin, Curtis Tatsuoka, Nori M. Minich, Peter M. MacFarlane, Anna Maria Hibbs
Summary: Intermittent hypoxemia (IH) events in preterm neonates are associated with oxidative stress and damage to lipids, proteins, and DNA. This study explores the relationship between IH parameters and oxidative stress biomarkers in urine samples. The findings suggest that these biomarkers may be useful in identifying high-risk neonates.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Peter Mathew MacFarlane, Richard John Martin, Juliann Marie Di Fiore, Thomas Michael Raffay, Curtis Tatsuoka, Zhengyi Chen, Nori Minich, Guillermo Quintas, Angel Sanchez-Illana, Julia Kuligowski, Jose David Pineiro-Ramos, Maximo Vento, Anna Maria Hibbs
Summary: This study investigated the relationship between neurotransmitter plasma levels and hypoxemia parameters in preterm neonates. The results showed that plasma levels of serotonin and kynurenic acid may serve as biomarkers for hypoxemia in preterm neonates. This research helps identify newborns at risk of short- and long-term adverse outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Victoria Ramos-Garcia, Isabel Ten-Domenech, Alba Moreno-Gimenez, Laura Campos-Berga, Anna Parra-Llorca, Maria Gormaz, Maximo Vento, Melina Karipidou, Dimitrios Poulimeneas, Eirini Mamalaki, Eirini Bathrellou, Julia Kuligowski
Summary: Accurately assessing dietary intake in nutritional research is challenging but crucial. To overcome the subjectivity of self-reporting methods, the development of analytical methods for determining food intake and microbiota biomarkers is necessary. This study presents a UHPLC-MS/MS method for quantifying and semi quantifying food intake biomarkers (BFIs) and microbiota biomarkers in urine samples from lactating mothers. The analysis identified distinct clusters of samples based on biomarker concentrations and revealed correlations between certain BFIs and dietary recall data. These findings emphasize the feasibility, usefulness, and complementary nature of assessing BFIs, dietary recall, and microbiota biomarkers in nutrition cohort studies.
Review
Pediatrics
Victoria Ramos-Garcia, Isabel Ten-Domenech, Alba Moreno-Gimenez, Laura Campos-Berga, Anna Parra-Llorca, Amparo Ramon-Beltran, Maria J. Vaya, Fady Mohareb, Corentin Molitor, Paulo Refinetti, Andrei Silva, Luis A. Rodrigues, Serge Rezzi, Andrew C. C. Hodgson, Stephane Canarelli, Eirini Bathrellou, Eirini Mamalaki, Melina Karipidou, Dimitrios Poulimeneas, Mary Yannakoulia, Christopher K. Akhgar, Andreas Schwaighofer, Bernhard Lendl, Jennifer Karrer, Davide Migliorelli, Silvia Generelli, Maria Gormaz, Miltiadis Vasileiadis, Julia Kuligowski, Maximo Vento
Summary: This study aims to compare the effect of mother's own milk (OMM) and pasteurized donor human milk (DHM) on % weight gain/month in preterm and term infants. It also evaluates the impact of diet, lifestyle habits, psychological stress, and pasteurization on milk composition and their influence on infant growth, health, and development. Biological samples and various characteristics are collected at different time points for analysis. The study also involves the use of sensor prototypes, measurement of maternal psychosocial status, examination of postpartum bonding and parental stress, and application of neurodevelopment scales.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemical Research Methods
Stephen J. Fleming, Mark D. Chaffin, Alessandro Arduini, Amer-Denis Akkad, Eric Banks, John C. Marioni, Anthony A. Philippakis, Patrick T. Ellinor, Mehrtash Babadi
Summary: CellBender, with its deep generative model, is able to simulate and denoise droplet-based single-cell data, improving the accuracy of multiple downstream analyses. It accurately distinguishes cell-containing droplets from cell-free droplets, learns the background noise profile, and provides noise-free quantification in an end-to-end manner.
Article
Biochemistry & Molecular Biology
Rocio Garcia-Arroyo, Elena B. Domenech, Carlos Herrera-Ubeda, Miguel A. Asensi, Cristina Nunez de Arenas, Jose M. Cuezva, Jordi Garcia-Fernandez, Federico Pallardo, Serena Mirra, Gemma Marfany
Summary: The retina is highly susceptible to genetic and environmental changes that result in oxidative stress and cell damage. CERKL is an important gene that protects against oxidative stress in the retina. This study using a mouse model found that Cerkl knockdown leads to abnormal stress response and cell death mechanisms in the retina, ultimately causing blindness.
Article
Biochemistry & Molecular Biology
Clara Mayayo-Vallverdu, Miguel Lopez de Heredia, Esther Prat, Laura Gonzalez, Meritxell Espino Guarch, Clara Vilches, Lourdes Munoz, Miguel A. Asensi, Carmen Serra, Amadeu Llebaria, Mercedes Casado, Rafael Artuch, Gloria Garrabou, Pablo M. Garcia-Roves, Federico V. Pallardo, Virginia Nunes
Summary: The high recurrence rate of cystine lithiasis in cystinuria patients calls for new therapeutic options. Antioxidant defect has been observed in cystinuria, leading to testing of antioxidant molecules as new treatments. In this study, L-Ergothioneine was found to decrease stone formation rate by over 60% and delay onset of calculi in a mouse model.
Review
Pediatrics
Anup Katheria, Georg M. Schmolzer, Annie Janvier, Vishal Kapadia, Ola D. Saugstad, Maximo Vento, Alla Kushnir, Mark Tracy, Wade Rich, Ju Lee Oei
Summary: Emergency research studies, especially those involving newborn infants, often face difficulties in obtaining informed consent due to the severity of the patients' conditions. The waiver or deferred consent process is needed to include sick patients who are unable to provide prospective consent. However, this process can lead to conflicting stakeholder views and pose challenges to research. This manuscript discusses the necessity of consent waiver or deferred consent processes for neonatal emergency research and provides a framework to balance the patients' best interests with ethical knowledge acquisition.
Article
Pediatrics
Alvaro Solaz-Garcia, Angel Sanchez-Illana, Inmaculada Lara-Canton, Raimunda Montejano-Lozoya, Ana Gimeno-Navarro, Alejandro Pinilla-Gonzalez, Laura Torrejon-Rodriguez, Maximo Vento, Pilar Saenz-Gonzalez
Summary: This study aimed to investigate the effect of kangaroo care on cerebral fractional tissue oxygen extraction (FtOE) in premature infants and compare the stability of cardiorespiratory parameters and the occurrence of hypoxic or bradycardic events between kangaroo care and incubator care. The results showed that during kangaroo care, cerebral metabolic demand was lower and cerebral oxygenation was higher compared to post-kangaroo care period, indicating the advantage of kangaroo care in promoting cerebral oxygenation and reducing metabolic demand in premature infants.
Article
Pediatrics
David G. Sweet, Virgilio P. Carnielli, Gorm Greisen, Mikko Hallman, Katrin Klebermass-Schrehof, Eren Ozek, Arjan te Pas, Richard Plavka, Charles C. Roehr, Ola D. Saugstad, Umberto Simeoni, Christian P. Speer, Maximo Vento, Gerry H. A. Visser, Henry L. Halliday
Summary: The sixth version of European Guidelines for the Management of RDS has been developed by a panel of experienced European neonatologists and an expert perinatal obstetrician based on available literature up to end of 2022. These updated guidelines aim to optimize outcomes for babies with RDS through various measures such as prediction of risk of preterm delivery, appropriate maternal transfer to a perinatal center, and evidence-based lung-protective management. The guidelines also address the importance of general care for infants with RDS, including cardiovascular support and judicious use of antibiotics. The guidelines have received endorsement from the European Society for Paediatric Research (ESPR) and the Union of European Neonatal and Perinatal Societies (UENPS). Rating: 7 out of 10.
