Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Medicine, Research & Experimental
Fei Song, Xiao-Xia Zhou, Yu Hu, Gang Li, Yan Wang
Summary: The IGF system plays multiple roles in disease development by regulating cell proliferation and differentiation. IGFBPs can bind to IGFs and perform different functions, possibly having broader functions through IGF-independent mechanisms.
ADVANCES IN THERAPY
(2021)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Review
Endocrinology & Metabolism
Laura E. Dichtel, Jose Cordoba-Chacon, Rhonda D. Kineman
Summary: This article summarizes the high prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with obesity and its progression to nonalcoholic steatohepatitis (NASH). Understanding the etiology of NAFLD is clinically relevant as it is an independent risk factor for diabetes and cardiovascular disease. The potential role of growth hormone and insulin-like growth factor 1 in regulating hepatic steatosis, inflammation, and fibrosis is discussed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Jonathan A. Zegarra-Valdivia, Jaime Pignatelli, Angel Nunez, Ignacio Torres Aleman
Summary: Understanding the mechanisms of resilience and vulnerability to Alzheimer's disease (AD) may lead to the identification of new treatment targets. Insulin-like growth factor I (IGF-I) activity in the brain plays a role in both resilience and vulnerability to AD. Preserved brain IGF-I activity is associated with resilience to AD pathology, while disturbed IGF-I activity is found in many AD risk factors. Considering IGF-I activity may help prevent the progression of AD pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Umeharu Ohto
Summary: Innate immunity is a crucial defense mechanism against microbial infections. Innate immune pattern recognition receptors (PRRs) play significant roles in detecting invading pathogens and activating the immune response. Cellular components and pathogen-associated molecular patterns (PAMPs) can trigger inflammatory responses and activate the immune system. Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) constitute a major family of intracellular PRRs and are involved in various diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Yi-Wei Lin, Xue-Fen Weng, Bin-Liang Huang, Hai-Peng Guo, Yi-Wei Xu, Yu-Hui Peng
Summary: IGFBP-1, a component of the IGF system, plays a crucial role in normal growth and development, as well as in the pathophysiology of various tumors. It regulates tumor behaviors through different molecular mechanisms and may serve as a potential diagnostic or prognostic biomarker in cancer.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sandra Diaz del Moral, Maha Benaouicha, Ramon Munoz-Chapuli, Rita Carmona
Summary: The translation introduces the importance of insulin and insulin-like growth factors during embryonic development and their role in cardiac development and cardiomyocyte proliferation. The study also discusses the clinical potential of utilizing the IGF signaling pathway for adult cardiac repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Faizullah Khan, Haroon Khan, Ajmal Khan, Masao Yamasaki, Naima Moustaid-Moussa, Ahmed Al-Harrasi, Shaikh Mizanoor Rahman
Summary: This article discusses how autophagy regulates adipogenesis and how bioactive compounds affect adipogenesis by manipulating autophagy. Understanding autophagy is crucial for the treatment and prevention of obesity and its associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Neurosciences
Yue Le, Xin Chen, Long Wang, Wan-you He, Jian He, Qing-ming Xiong, Yun-hua Wang, Lei Zhang, Xue-qin Zheng, Han-bing Wang
Summary: This study found that IGF-1 signaling plays a vital role in chemotherapy-induced peripheral neuropathy (CIPN) and targeting this pathway could be an effective therapeutic strategy for treating CIPN in clinical settings.
BRAIN RESEARCH BULLETIN
(2021)
Article
Medical Laboratory Technology
Jason K. Y. Lee, Kendall Cradic, Ravinder J. Singh, JoAnna Jones, Jieli Li
Summary: This study compared the measurement of IGF-1 on four different platforms and found significant variations between them. These variations should be considered when managing patients with pituitary disorders.
CLINICA CHIMICA ACTA
(2023)