Article
Biochemistry & Molecular Biology
Mariana Silva Thomaz, Marcela Nascimento Sertorio, Marcos Leoni Gazarini, Daniel Araki Ribeiro, Luciana Pellegrini Pisani, Marcia Regina Nagaoka
Summary: Non-alcoholic fatty liver is the leading cause of liver disease worldwide. This study investigated the role of kinins in experimental non-alcoholic steatohepatitis (NASH) and found that kinins affect the antioxidant system and reduce superoxide dismutase activity in NASH.
Article
Biochemistry & Molecular Biology
Ignazio S. Piras, Anish Raju, Janith Don, Nicholas J. Schork, Glenn S. Gerhard, Johanna K. DiStefano
Summary: Choline deficiency is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD) and more advanced NAFLD-related hepatic fibrosis. Reduced expression of the hepatic phosphatidylethanolamine N-methyltransferase (PEMT) enzyme causes steatosis, inflammation, and fibrosis in mice, and common PEMT variants in humans impair phosphatidylcholine synthesis and increase NAFLD risk. This study investigated the expression of hepatic PEMT and its genetic variants in a large cohort of NAFLD patients and found that reduced PEMT expression is linked to inflammation and fibrosis in NAFLD patients, with severity of fibrosis being a factor. Additionally, reduced PEMT expression was observed in postmenopausal women with NAFLD, and certain genetic variants were suggestive of an association with hepatic fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
An-Ming Yang, Chien-Yu Lin, Shih-Hao Liu, Guan-Da Syu, Hao-Jhe Sun, Kuei-Chuan Lee, Han-Chieh Lin, Ming-Chih Hou
Summary: Saccharomyces boulardii (SB), a dietary supplement yeast, has been shown to improve non-alcoholic steatohepatitis (NASH) symptoms by maintaining gut integrity, increasing microbial diversity, and increasing the number of potentially beneficial gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Alarcon-Vila, Naroa Insausti-Urkia, Sandra Torres, Paula Segales-Rovira, Laura Conde de la Rosa, Susana Nunez, Raquel Fucho, Jose C. Fernandez-Checa, Carmen Garcia-Ruiz
Summary: Alcoholic (ASH) and nonalcoholic (NASH) steatohepatitis are advanced stages of fatty liver disease. Methionine adenosyltransferase 1A (MAT1A) plays a key role in hepatic methionine metabolism and germline Mat1a deletion in mice promotes NASH. Acid sphingomyelinase (ASMase) triggers hepatocellular apoptosis and liver fibrosis and has been shown to downregulate MAT1A expression in the context of fulminant liver failure. Disruption of methionine metabolism sensitizes to steatohepatitis by ASMase activation via decreased SAM/SAH.
Article
Gastroenterology & Hepatology
Yu Jung Heo, Sung-E Choi, Nami Lee, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Yup Kang, Kwan Woo Lee, Hae Jin Kim
Summary: Visfatin injection aggravated hepatic steatosis, inflammation, and fibrosis in the MCD-diet-induced steatohepatitis mouse model by inducing ER and oxidative stress.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Akihiro Kawahara, Keishi Kanno, Sayaka Yonezawa, Yuichiro Otani, Tomoki Kobayashi, Susumu Tazuma, Masanori Ito
Summary: This study investigates the effects of hepatic stellate cell (HSC) depletion on the development of hepatic steatosis and fibrosis in a murine non-alcoholic steatohepatitis (NASH) model. The results suggest that depletion of HSCs may improve hepatic lipid metabolism and fibrogenesis, making them potential therapeutic targets for NASH treatment.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Wei Wang, Ting Zhai, Ping Luo, Xiaolei Miao, Junjun Wang, Yong Chen
Summary: The study showed that SIL treatment reduced serum lipids and bile acid levels in MCD mice, while increasing beneficial microorganisms. This alleviative effect may be achieved by influencing the composition of the gut microbiota and regulating the levels of serum lipids and bile acids through the enterohepatic axis.
FRONTIERS IN NUTRITION
(2023)
Article
Medical Laboratory Technology
Emmanuel Somm, Sophie A. Montandon, Ursula Loizides-Mangold, Nadia Gaia, Vladimir Lazarevic, Claudio De Vito, Elodie Perroud, Marie-Luce Bochaton-Piallat, Charna Dibner, Jacques Schrenzel, Francois R. Jornayvaz
Summary: The study shows that the GLP-1 receptor agonist liraglutide can prevent the accumulation of C16 and C24 ceramides/sphingomyelins species, alleviate inflammation, and inhibit the initiation of fibrosis in the liver of MCD-diet-fed mice. Additionally, liraglutide influences the composition of gut microbiota induced by the MCD-diet.
TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Analytical
Meng-juan Gong, Cai-yan Zhu, Zhong-jie Zou, Bin Han, Ping Huang
Summary: The study evaluated the beneficial effects and underlying mechanisms of puerarin on MCD diet-induced NASH in mice using metabonomics and gene sequencing. Puerarin improved hepatic steatosis and inflammation in NASH mice by ameliorating metabolic disorders and rebalancing gut flora. The findings provide new insights into NASH pathogenesis and support the use of puerarin as an anti-NASH agent.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Agriculture, Dairy & Animal Science
S. B. Potts, K. M. Brady, C. M. Scholte, K. M. Moyes, N. E. Sunny, R. A. Erdman
Summary: Feeding supplemental choline and Met during the periparturient period can positively affect cow performance, but the mechanisms are unclear.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Reyes Gamez-Belmonte, Mireia Tena-Garitaonaindia, Cristina Hernandez-Chirlaque, Samir Cordova, Diego Ceacero-Heras, Fermin Sanchez de Medina, Olga Martinez-Augustin
Summary: The study showed that TNAP haplodeficient mice can develop hepatosteatosis similar to that induced by a MCD diet when fed a control diet, but without weight loss, increased ALT levels, or hypoglycemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Nouf Aljobaily, Kelsey Krutsinger, Michael J. Viereckl, Raznin Joly, Bridger Menlove, Brexton Cone, Ailaina Suppes, Yuyan Han
Summary: This study demonstrates the therapeutic potential of cannabigerol (CBG), a plant-derived non-psychotropic compound, in reducing hepatic steatosis, fibrosis, and inflammation in Non-Alcoholic Steatohepatitis (NASH). The low dose of CBG alleviated hepatic fibrosis and inflammation, while the high dose of CBG showed enhanced liver damage.
Article
Food Science & Technology
Xinwei Jiang, Xia Li, Wenjun Feng, Yige Qin, Zhen Li, Hua Nie, Weibing Qin, Lu Han, Weibin Bai
Summary: This study demonstrates the importance of methionine and choline in diet and emphasizes the crucial role of cooking conditions, which are dietary factors that influence the quality of sperm production. The results showed that a methionine-choline deficient diet induced testicular degradation and damage to spermatocytes, while baking the diet further aggravated testicular injury and significantly reduced sperm density, motility, and normal sperm morphology. These effects were not related to the blood-testis barrier or Leydig cell dysfunction, but were associated with spermatocyte loss and apoptosis mediated by endoplasmic reticulum stress.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Rong Liu, Qiyu Diao, Kai Cui
Summary: The study examined the relationship among dietary methionine pattern, methionine metabolism, and antioxidant reactions in lambs to provide theoretical basis for amino acid nutrition and healthy feeding. Methionine restriction can alter the content of methionine and its metabolites, affecting the redox state by activating the Nrf(2) signaling pathway. Liver tissue adapts to oxidative environment by upregulating expression of antioxidant enzymes like GSH-Px and SOD, with a lag effect in metabolic recovery after methionine supplementation.
Article
Endocrinology & Metabolism
Shuquan Lv, Zhongyong Zhang, Xiuhai Su, Wendong Li, Xiaoyun Wang, Baochao Pan, Hanzhou Li, Hui Zhang, Yuansong Wang
Summary: Qingrequzhuo capsule (QRQZ), composed of various plant extracts, has been used to treat nonalcoholic steatohepatitis (NASH). This study found that QRQZ reduced lipid accumulation and inflammation in NASH mice by modulating gut microbiota, enhancing gut barrier function, and inhibiting TLR4/NF-kB signaling pathway activation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Seiichi Nagano, Yoko Takahashi, Kazuhiro Yamamoto, Hiroshi Masutani, Noriko Fujiwara, Makoto Urushitani, Toshiyuki Araki
HUMAN MOLECULAR GENETICS
(2015)
Article
Biochemistry & Molecular Biology
Junji Yodoi, Hai Tian, Hiroshi Masutani, Hajime Nakamura
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Obstetrics & Gynecology
Haruta Mogami, Shigeo Yura, Eiji Kondoh, Hiroshi Masutani, Junji Yodoi, Ikuo Konishi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2017)
Article
Multidisciplinary Sciences
Shuji Matsuoka, Yasuyuki Ishii, Atsuhito Nakao, Masaaki Abe, Naomi Ohtsuji, Shuji Momose, Hui Jin, Hisashi Arase, Koichi Sugimoto, Yusuke Nakauchi, Hiroshi Masutani, Michiyuki Maeda, Hideo Yagita, Norio Komatsu, Okio Hino
Review
Nutrition & Dietetics
Junji Yodoi, Yoshiyuki Matsuo, Hai Tian, Hiroshi Masutani, Takashi Inamoto
Article
Biochemistry & Molecular Biology
Yoshiyuki Matsuo, Kana Irie, Hiroshi Kiyonari, Hiroaki Okuyama, Hajime Nakamura, Aoi Son, Dorys Adriana Lopez-Ramos, Hai Tian, Shin-Ichi Oka, Katsuya Okawa, Shinae Kizaka-Kondoh, Hiroshi Masutani, Junji Yodoi
ANTIOXIDANTS & REDOX SIGNALING
(2013)
Article
Biochemistry & Molecular Biology
Yukiko Taketani, Kimihiro Kinugasa, Rie Kitajima, Shin Nishiumi, Hitoshi Ashida, Hajime Nakamura, Tuyosi Fujita, Ken Kanzaki, Hiroshi Masutani, Junji Yodoi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2014)
Article
Critical Care Medicine
Masato Yashiro, Hirokazu Tsukahara, Akihiro Matsukawa, Mutsuko Yamada, Yosuke Fujii, Yoshiharu Nagaoka, Mitsuru Tsuge, Nobuko Yamashita, Toshihiro Ito, Masao Yamada, Hiroshi Masutani, Junji Yodoi, Tsuneo Morishima
CRITICAL CARE MEDICINE
(2013)
Review
Nutrition & Dietetics
Hiroshi Masutani, Eiji Yoshihara, So Masaki, Zhe Chen, Junji Yodoi
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2012)
Article
Multidisciplinary Sciences
Kengo Asami, Akiko Inagaki, Takehiro Imura, Satoshi Sekiguchi, Keisei Fujimori, Hiroshi Masutani, Junji Yodoi, Susumu Satomi, Noriaki Ohuchi, Masafumi Goto
Article
Multidisciplinary Sciences
Fernando Toshio Ogata, Wagner Luiz Batista, Adriano Sartori, Tarsis Ferreira Gesteira, Hiroshi Masutani, Roberto Jun Arai, Junji Yodoi, Arnold Stern, Hugo Pequeno Monteiro
Article
Biochemistry & Molecular Biology
Cristiane Lumi Hirata, Shinji Ito, Hiroshi Masutani
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Biochemistry & Molecular Biology
Mina Noura, Hidemasa Matsuo, Asami Koyama, Souichi Adachi, Hiroshi Masutani
Article
Biochemistry & Molecular Biology
Hiroshi Masutani
Summary: Thioredoxin-interacting protein (Txnip) is a critical cancer suppressor and regulator of energy metabolism; the mechanism of action of Txnip remains to be fully elucidated and requires further investigation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Multidisciplinary Sciences
Cristiane Lumi Hirata, Shinji Ito, Hiroshi Masutani