Contribution of the Nitroimidazoles PA-824 and TBA-354 to the Activity of Novel Regimens in Murine Models of Tuberculosis

In VitroandIn VivoActivities of the Nitroimidazole TBA-354 against Mycobacterium tuberculosis

(2014) A. M. Upton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sterilizing Activities of Novel Combinations Lacking First- and Second-Line Drugs in a Murine Model of Tuberculosis

(2012) Kathy Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824

(2012) Andreas H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dose-Ranging Comparison of Rifampin and Rifapentine in Two Pathologically Distinct Murine Models of Tuberculosis

(2012) Ian M. Rosenthal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis [Short communication]

(2012) C. Pierre-Audigier et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial

(2012) Andreas H Diacon et al.   LANCET

Delamanid for Multidrug-Resistant Pulmonary Tuberculosis

(2012) Maria Tarcela Gler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid Evaluation in Whole Blood Culture of Regimens for XDR-TB Containing PNU-100480 (Sutezolid), TMC207, PA-824, SQ109, and Pyrazinamide

(2012) Robert S. Wallis et al.   PLoS One

Sterilizing Activity of Novel TMC207- and PA-824-Containing Regimens in a Murine Model of Tuberculosis

(2011) Rokeya Tasneen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Susceptibility of ClinicalMycobacterium tuberculosisIsolates to a Potentially Less Toxic Derivate of Linezolid, PNU-100480

(2011) J. W. C. Alffenaar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Pharmacodynamics of TMC207 and ItsN-Desmethyl Metabolite in a Murine Model of Tuberculosis

(2011) Marie-Claude Rouan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients

(2011) A. H. Diacon et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Sterilizing Activity of Second-Line Regimens Containing TMC207 in a Murine Model of Tuberculosis

(2011) Nicolas Veziris et al.   PLoS One

Bactericidal Potencies of New Regimens Are Not Predictive of Their Sterilizing Potencies in a Murine Model of Tuberculosis

(2010) K. Andries et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early Bactericidal Activity and Pharmacokinetics of PA-824 in Smear-Positive Tuberculosis Patients

(2010) A. H. Diacon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis

(2010) Robert S. Wallis et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Whole‐Blood Bactericidal Activity againstMycobacterium tuberculosisof Single Doses of PNU‐100480 in Healthy Volunteers

(2010) Robert S. Wallis et al.   JOURNAL OF INFECTIOUS DISEASES

Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

(2010) Iveta Kmentova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sterilizing Activity of R207910 (TMC207)-containing Regimens in the Murine Model of Tuberculosis

(2009) Murad Ibrahim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Addition of PNU-100480 to First-Line Drugs Shortens the Time Needed to Cure Murine Tuberculosis

(2009) Kathy N. Williams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Synthesis and Structure−Activity Studies of Biphenyl Analogues of the Tuberculosis Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

(2009) Brian D. Palmer et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis

(2009) Andreas H. Diacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model

(2008) K. N. Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enhanced Bactericidal Activity of Rifampin and/or Pyrazinamide When Combined with PA-824 in a Murine Model of Tuberculosis

(2008) R. Tasneen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Powerful Bactericidal and Sterilizing Activity of a Regimen Containing PA-824, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis

(2008) E. Nuermberger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pyrazinamide Resistance among South African Multidrug-Resistant Mycobacterium tuberculosis Isolates

(2008) M. Mphahlele et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution

(2008) Robert F. Anderson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY