Article
Infectious Diseases
Peng He, Xin Li, Xiaohan Guo, Xingchen Bian, Rui Wang, Yue Wang, Sijing Huang, Mengya Qi, Yuanxia Liu, Meiqing Feng
Summary: LYSC98 showed a universal antibacterial effect in Staphylococcus aureus with an MIC range of 2-4 μg/mL. In vivo, LYSC98 demonstrated distinctive mortality protection in mice sepsis model. The pharmacokinetic results displayed the range of maximum plasma concentration, area under the concentration-time curve, and elimination half-life of LYSC98. Cmax/MIC was proved to be the most suitable PK/PD index for LYSC98 to predict its antibacterial efficacy.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Erika Watanabe, Kazuaki Matsumoto, Kazuro Ikawa, Yuta Yokoyama, Akari Shigemi, Yuki Enoki, Yasuhiro Umezaki, Koyo Nakamura, Keiichiro Ueno, Hideyuki Terazono, Norifumi Morikawa, Yasuo Takeda
Summary: The study investigated the PK/PD indices of teicoplanin against Staphylococcus aureus using a murine infection model. The results suggest that fC(max)/MIC and fAUC(24)/MIC are useful PK/PD indices of teicoplanin against MSSA and MRSA, providing valuable insights for optimizing antimicrobial therapy.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Multidisciplinary Sciences
K. Rox
Summary: This study investigates whether tramadol influences the bacterial burden in the primary organ, the thighs, and organs affected by secondary seeding in the neutropenic thigh infection model. It was shown that tramadol did not influence the bacterial burden for most strains tested, except for one strain of A. baumannii. Consequently, tramadol is considered an option to reduce discomfort in the untreated group for the majority of ESKAPE pathogens tested, contributing to the refinement of the standard PK/PD model.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Xueling Zheng, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Jianhua Wang
Summary: This study demonstrates that NZX exhibits potent antibacterial activity against pathogenic bacteria S. aureus, with lower risk of resistance compared to other antibiotics. NZX shows favorable pharmacokinetic properties and effectiveness in treating peritonitis caused by S. aureus, making it a potential candidate for further development.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Ping Zheng, Fang Liu, Jinzhao Long, Yuefei Jin, Shuaiyin Chen, Guangcai Duan, Haiyan Yang
Summary: Staphylococcus aureus is a significant human pathogen that can cause a wide range of diseases. Conventional mouse studies lack predictive ability due to the differences in immune systems between mice and humans. Humanized mice provide a promising model for studying human-specific virulence factors and the interaction mechanisms of S. aureus with humans.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Agriculture, Multidisciplinary
Zhang Hui-lin, Zhao Yi-yang, Zhou Zi-chong, Ding Huan-zhong
Summary: In this study, the susceptibility breakpoints of cefquinome against E. coli and S. aureus in pigs were determined, with low resistance rates observed. Pharmacokinetic/pharmacodynamic cut-off values were established, providing guidance for effective treatment of infections caused by these bacteria strains. Adjustment of dosing regimen showed increased effectiveness for S. aureus infections, highlighting the importance of surveillance and dosage guidance for cefquinome in pigs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Microbiology
Randhir Yedle, Mahesh Kumar Reniguntla, Ramesh Puttaswamy, Pradeep Puttarangappa, Somashekharayya Hiremath, Mahesh Nanjundappa, Ramesh Jayaraman
Summary: This study characterized the pharmacokinetics/pharmacodynamics (PK/PD) of ciprofloxacin against bacterial pathogens in the rat neutropenic thigh infection (NTI) model. The results showed that the PK/PD targets of ciprofloxacin achieved in rats were similar to those reported in human patients, demonstrating the usefulness of the rat model for evaluating anti-infective agents intended to be administered as intravenous infusions in the clinic and increasing the robustness of PK/PD predictions in humans.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Maxwell J. Lasko, Tomefa E. Asempa, David P. Nicolau
Summary: Efforts to develop novel oral beta-lactamase inhibitors to treat ESBL and carbapenemase-producing Enterobacterales are progressing. Ceftibuten, a third-generation cephalosporin, has been studied for its pharmacokinetics and pharmacodynamics in a murine infection model. Different ceftibuten regimens were tested to achieve specific fT > MIC targets for bacterial burden reduction. Results suggest that fT > MIC targets can guide ceftibuten dosage selection for optimal clinical efficacy.
Article
Pharmacology & Pharmacy
Xin Li, Yuancheng Chen, Xiaoyong Xu, Yi Li, Yaxin Fan, Xiaofen Liu, Xingchen Bian, Hailan Wu, Xu Zhao, Meiqing Feng, Beining Guo, Jing Zhang
Summary: This study investigated the pharmacokinetic/pharmacodynamic (PK/PD) targets and breakpoints of Nemonoxacin for treating Streptococcus pneumoniae-induced pneumonia. The free-drug plasma fAUC(0-24)/MIC ratio was found to be strongly associated with efficacy. Recommended susceptibility breakpoints for Nemonoxacin against S. pneumoniae were suggested.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Linglin Gao, Hao Zhu, Yun Chen, Yuhui Yang
Summary: The study revealed that the resistance to CEQ increased cumulatively with extended administration time, and resistant strains only appeared when %T > mutant prevention concentration >= 50%. Following CEQ treatment, 45 proteins showed significant changes in expression, mainly involved in metabolic and intracellular processes on cells and cell membranes, with catalytic and binding activities. Genes like RPSO, SDHB, CITZ, ADK, and SAOUHSC 00113 in S. aureus may be crucial in the development of resistance to CEQ. These findings provide important candidate proteins as targets to overcome S. aureus resistance to CEQ.
JOURNAL OF MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Magda Ferreira, Sandra N. Pinto, Frederico Aires-da-Silva, Ana Bettencourt, Sandra I. Aguiar, Maria Manuela Gaspar
Summary: The study evaluated the therapeutic benefits of combining three antibiotics (vancomycin, levofloxacin, and rifabutin) with nanotechnological platforms, with RFB showing the strongest antibacterial effect when incorporated into liposomes. Negatively charged RFB liposomes showed promising potential against biofilm-associated Staphylococcus aureus infections and displayed better performance in in vitro studies. Further in vivo studies are recommended to validate the findings.
Article
Infectious Diseases
A. J. Heffernan, F. B. Sime, S. Mohd Sazlly Lim, S. Adiraju, S. C. Wallis, J. Lipman, G. D. Grant, J. A. Roberts
Summary: This study investigated the pharmacodynamics of ceftriaxone against methicillin-susceptible Staphylococcus aureus (MSSA) and determined the optimal dosage. The results showed that only a high ceftriaxone dose of 2 g twice daily achieved bacterial killing and sustained inhibition of bacterial growth.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Pharmacology & Pharmacy
Katharina Rox, Tim Becker, Andrea Schiefer, Miriam Grosse, Alexandra Ehrens, Rolf Jansen, Tilman Aden, Stefan Kehraus, Gabriele M. Koenig, Anna K. Krome, Marc P. Huebner, Karl G. Wagner, Marc Stadler, Kenneth Pfarr, Achim Hoerauf
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a high priority pathogen organism, causing significant global mortality. The natural product CorA, currently in preclinical development, demonstrates effectiveness against MRSA in vitro. This study evaluates the pharmacokinetics and pharmacodynamics of CorA, suggesting its potential for MRSA and MSSA-related infections.
Article
Multidisciplinary Sciences
Qingwen Yang, Chenghuan Zhang, Xuesong Liu, Longfei Zhang, Kang Yong, Qian Lv, Yi Zhang, Liang Chen, Peng Zhong, Yun Liu
Summary: In this study, the associations between the specific pharmacokinetics and pharmacodynamics of cefquinome and its antibacterial activity against Streptococcus agalactiae were evaluated. The findings showed that when the concentration of cefquinome reached 81%, the density of Streptococcus agalactiae was reduced by 2-log(10). These findings provide valuable insights for optimizing the dose regimens of cefquinome in the treatment of S. agalactiae infections.
Article
Veterinary Sciences
Li-jie Jiang, Xia Xiao, Ke-xu Yan, Tian Deng, Zhi-qiang Wang
Summary: This study evaluated the pharmacokinetics and pharmacodynamics of cefquinome and established a dose and cutoff value for its efficacy against Staphylococcus aureus. The results showed that cefquinome can effectively kill S. aureus in bovine mastitis within the recommended dosage range, making it a valuable treatment option in veterinary medicine.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Medicinal
Guo-Ning Zhang, Qiang Li, Jianyuan Zhao, Xuandi Zhang, Zhuxin Xu, Yujia Wang, Yuanhui Fu, Qi Shan, Yanpeng Zheng, Juxian Wang, Mei Zhu, Ziqiang Li, Shan Cen, Jinsheng He, Yucheng Wang
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biodiversity Conservation
Wenping Xie, Jiangang Zhao, Qiyuan Zhang, Changpeng Ye, Guangming Zheng, Qi Shan, Lichun Li, Xiaofeng Shao
ECOLOGICAL INDICATORS
(2020)
Article
Fisheries
Wenjing Zhang, Jingxin Wang, Guangming Zheng, Yi Yin, Xinping Zhu, Qi Shan, Yuanhao Yang, Lisha Ma, Lichun Li, Shugui Liu
Summary: This study demonstrated that ENR had slow absorption, long half-life, and wide tissue distribution in northern snakehead, primarily metabolized in the liver. It is effective in treating infections caused by susceptible strains with MIC values below 0.7 μg/mL, with a recommended withdrawal period of at least 18 days at 25°C after treatment ceased.
Article
Chemistry, Medicinal
Mei Zhu, Qi Shan, Ling Ma, Jiajia Wen, Biao Dong, Guoning Zhang, Minghua Wang, Juxian Wang, Jinming Zhou, Shan Cen, Yucheng Wang
Summary: A novel class of HIV-1 PR/RT dual inhibitors was designed and evaluated, showing significant improvement in HIV-1 RT inhibitory activity while maintaining comparable or improved potency against PR. Some inhibitors displayed excellent anti-HIV-1 activity, with a more reasonable ratio between PR and RT inhibition, providing new insight for further optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Microbiology
Bing Yu, Chuanyu Han, Junwei Zhao, Yuting Zhang, Qiqi Shan, Yan Wu, Hanxun Ju, Wensheng Xiang, Xiangjing Wang
Summary: Strain NEAU-YB345(T) is a novel acidophilic actinobacterium belonging to the genus Streptacidiphilus, with high 16S rRNA gene sequence similarities to other species within the genus. It possesses unique cell wall composition, sugar profile, and phospholipid composition, representing a new species within the Streptacidiphilus genus.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhen-Ning Lu, Qi Shan, Shang-Jiu Hu, Yue Zhao, Guo-Ning Zhang, Mei Zhu, Dong-Ke Yu, Ju-Xian Wang, Hong-Wei He
Summary: Liver fibrosis is a common consequence of chronic liver diseases. Novel derivatives of 1-(substituted phenyl)-1,8-naphthalidine-3-carboxamide were synthesized, with compounds 17f and 19g showing inhibitory effects on fibrogenic markers and signaling pathways related to hepatic fibrogenesis. Compound 19g also demonstrated significant antifibrotic effects in vivo in BDL rats.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Lichun Li, Yi Yin, Guangming Zheng, Shugui Liu, Cheng Zhao, Wenping Xie, Lisha Ma, Qi Shan, Xiaoxin Dai, Linting Wei
Summary: A sensitive method for determining nine herbicides in sediments and aquatic products was developed using QuEChERS and UHPLC-MS/MS, with satisfactory recoveries and linear calibration curves. While the residues of herbicides in paddy fish did not harm humans in the rice-fish co-culture system, there were ecological risks to fish, daphnia, and algae in the system.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
Hui Jin, Cheng Zhao, Yi Yin, Guangming Zheng, Lichun Li, Qi Shan, Meiyu Zhang, Linting Wei, Xiaona Shi, Heqing Huang, Wenjing Zhang, Shugui Liu
Summary: A method for simultaneous detection of active clinical components of teicoplanin and ramoplanin in environmental water was established and validated using LC-MS/MS combined with cascade elution. This cascade elution method, which is rapid, solvent-less, and high-extraction efficient, successfully enabled the one-step extraction and purification of seven targets.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Shangjiu Hu, Ling Ma, Biao Dong, Qi Shan, Jinming Zhou, Guoning Zhang, Minghua Wang, Shan Cen, Mei Zhu, Juxian Wang, Yucheng Wang
Summary: A new class of HIV-1 protease inhibitors with phenol derived P2 ligands and nitro or halogens in P2' ligands have been designed and synthesized. Compound 17d displays potent enzyme inhibitory activity and greater antiviral activity against the DRV-resistant variant than the wild type virus.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Mei Zhu, Huiyu Zhou, Ling Ma, Biao Dong, Jiwei Ding, Jinming Zhou, Juxian Wang, Guoning Zhang, Minghua Wang, Qi Shan, Shan Cen, Yucheng Wang
Summary: In this study, a novel class of HIV-1 protease inhibitors with the free nitrogen or sulphone in morpholine cores as P2 ligands in combination with diverse substituted phenylsulfonamide P20 ligands was designed and biologically evaluated. These inhibitors exhibited prominent enzymatic inhibitory activity in low nanomolar ranges with relatively low cytotoxicity. In particular, inhibitor 1e demonstrated strong enzyme inhibitory activity, in vivo antiviral activity, and potency against drug-resistant variants. In silico studies provided molecular insights and predictions for further research.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Qiqi Shan, Chuang Han, Junwei Zhao, Bing Yu, Mengqi Jiang, Ting Liu, Xiangjing Wang, Wensheng Xiang
Summary: A novel lignin-degrading actinobacterium, Nocardia albiluteola, was isolated from pumpkin rhizosphere soil in Mudanjiang, Heilongjiang Province, northeast China. It exhibited unique morphological, chemotaxonomic, and genomic characteristics, distinguishing it from known strains.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Qi Shan, Heqing Huang, Guangming Zheng, Yi Yin, Xinping Zhu, Lisha Ma, Hao Zhou, Wenping Xie, Lichun Li, Shugui Liu, Jingxin Wang
Summary: This study investigated the pharmacokinetics, tissue distribution, and elimination of enrofloxacin and its metabolite ciprofloxacin in crucian carp. The results showed that enrofloxacin exhibited slow absorption, wide tissue distribution, and long elimination half-life in the fish. Multiple-dose administration resulted in significant accumulations of the drugs in the plasma and tissues.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Chuanyu Han, Yuting Zhang, Bing Yu, Qiqi Shan, Junwei Zhao, Haoran Shi, Yuanyuan Tian, Yan Zhang, Chunyu Zhu, Wensheng Xiang
Summary: NEAU-YY56(T) is a novel lignin-degrading actinomycete belonging to the genus Cellulomonas, with distinct characteristics from closely related species.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Engineering, Environmental
Jiawei Lin, Lichun Li, Lisha Ma, Yongyou Hu, Cheng Zhao, Linting Wei, Guangming Zheng, Shugui Liu, Qi Shan, Haoyi Zhao, Yi Yin
Summary: A novel Co-based N-doped carbon catalyst was successfully developed with high efficiency in degrading organic pollutant sulfamethoxazole, providing a new strategy for treating wastewater.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Jingxin Wang, Qi Shan, Ximei Liang, Fangling Guan, Zhi Zhang, Haomin Huang, Hansun Fang
JOURNAL OF HAZARDOUS MATERIALS
(2020)