Article
Infectious Diseases
Maria Lajarin-Reinares, Eloy Pena-Rodriguez, Mariona Canellas-Santos, Elisabet Rosell-Vives, Pilar Cortes, Montserrat Llagostera Casas, Maria Angels Calvo, Francisco Fernandez-Campos
Summary: Topically applied antimicrobial drugs have several advantages, but the widespread use of antibiotics has led to increasing antimicrobial resistance. Drug repurposing, such as with disulfiram, may provide an attractive alternative for treating multidrug-resistant bacteria in skin infections.
Article
Public, Environmental & Occupational Health
Rawan T. Tafish, Ahmed F. Alkhaldi, Anouar Bourghli, Turki A. Althunian
Summary: This study aimed to assess the effectiveness of topical vancomycin in minimizing the risk of SSIs in patients who underwent spinal surgeries. The results showed no lower association of SSIs with intra-wound vancomycin, further studies are needed.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Review
Infectious Diseases
Biagio Pinchera, Antonio Riccardo Buonomo, Nicola Schiano Moriello, Riccardo Scotto, Riccardo Villari, Ivan Gentile
Summary: Surgical site infections are a growing concern in nosocomial infections. Antibiotic resistance, increasing surgical interventions, and patients' complex comorbidities contribute to this problem. It is important to consider all risk factors, preventive measures, and possible therapeutic interventions in managing surgical site infections.
Article
Multidisciplinary Sciences
M. Alonso-Garcia, A. Toledano-Munoz, J. M. Aparicio-Fernandez, F. M. De-la-Rosa-Astacio, D. Rodriguez-Villar, A. Gil-de-Miguel, M. Duran-Poveda, G. Rodriguez-Caravaca
Summary: The study evaluated the adequacy of antibiotic prophylaxis in patients undergoing neck surgery and its relationship with the incidence of surgical site infection (SSI). It was found that antibiotic prophylaxis was adequate in the majority of patients and did not affect the occurrence of SSIs.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Sanjiv K. Hyoju, Robert Keskey, Gerardo Castillo, Kaylie Machutta, Alexander Zaborin, Olga Zaborina, John C. Alverdy
Summary: Pi-PEG is effective in preventing surgical site infection caused by gut-derived pathogens. In a mouse model, it was found that Pi-PEG added to drinking water protected against SSIs through modulation of the gut-wound microbiome.
Article
Biochemistry & Molecular Biology
Mahalakshmi Pandian, V. Anil Kumar, R. Jayakumar
Summary: The newly developed Cs-Ocd bandage with porous structure, enhanced swelling property, and controlled release of Ocd can significantly reduce skin infections. The bandage exhibits good hemostatic potential, antimicrobial, and anti-biofilm activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Public, Environmental & Occupational Health
S. M. de Almeida, F. G. de Menezes, M. D. Martino, C. R. Tachira, A. do R. Toniolo, H. L. Fukumoto, M. B. Edmond, A. R. Marra
Summary: Implementation of a surgical checklist leads to a significant reduction in surgical site infection, decrease in antimicrobial resistance, and reduction in in-hospital mortality.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Multidisciplinary Sciences
Ohad Meir, Fadia Zaknoon, Amram Mor
Summary: This study describes a new lipopeptide-like pentamer that exhibits antibiotic adjuvant properties. When combined with inefficient antibiotics, the pentamer shows systemic efficacy in mouse models. The adjuvant properties of the pentamer are mediated through interactions with the outer-membrane of bacteria, and it enhances the activity of hydrophobic antibiotics against Gram-negative pathogens.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Vural Yilmaz, Panayiota Louca, Louiza Potamiti, Mihalis Panayiotidis, Katerina Strati
Summary: This study successfully generated an in vivo lineage-tracing model to track papillomavirus-harboring cells and their progeny. By observing MmuPV1-treated tissues, increased proliferation dynamics and decreased MHC-I cell surface expression were found, which may have implications in tissue regenerative capacity and virus clearance. This model provides a novel tool to study the biology of MmuPV1 host-pathogen interactions.
Review
Public, Environmental & Occupational Health
Emmanuel Piednoir, Joan Robert-Yap, Patrice Baillet, Emilie Lermite, Niki Christou
Summary: Surgical site infections pose a significant economic burden, with costs varying depending on factors such as the patient and the type of surgery. Prevention of infections is a profitable concept for surgery and should be integrated into healthcare management globally.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Surgery
Nina S. Cohen, Jiselle M. Bock, Addison K. May
Summary: Surgical site infections are a significant cause of illness and death. There is strong evidence supporting several preventive measures, but their effective implementation is not optimal. It is crucial to identify high-risk patients and avoid pitfalls in diagnosing surgical site infections, especially in emergency surgery patients with physiological disorders. Maintaining a high level of suspicion after surgery is critical in identifying patients with surgical site infections and preventing failure to rescue.
Article
Biochemistry & Molecular Biology
Madelene A. Andersson, Lone Bruhn Madsen, Artur Schmidtchen, Manoj Puthia
Summary: This study introduces an ex vivo wound infection model using porcine skin and a burn wounding method, allowing for the efficacy evaluation of topical antimicrobial formulations. The results demonstrate compatibility with clinically relevant bacterial strains and confirm the effectiveness of antibacterial treatments, highlighting the formation of biofilms on the wound surface as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Andriy Hrynyshyn, Manuel Simoes, Anabela Borges
Summary: This review discusses new strategies to control and eradicate biofilms in surgical site infections (SSI), including the use of nanotechnology-based composites and natural plant-based products. It provides an overview of new therapeutic agents and approaches to control multidrug-resistant pathogenic microorganisms, particularly when biofilms are present in SSIs. It also discusses detection and real-time monitoring systems to improve biofilm control strategies and diagnosis of human infections.
Article
Infectious Diseases
Abdikarim Hussein Mohamed, Hussein Ali Mohamud, Ebubekir Arslan
Summary: The study found a 3.5% prevalence of surgical site infections, with Escherichia coli as the main pathogen and methicillin-resistant Staphylococcus aureus also present. Factors like antibiotic use, chronic renal failure, diabetes, and emergency surgeries were identified as predisposing to multidrug resistance. Pathogens displayed varying levels of resistance to antibiotics commonly used in surgical infections.
Article
Cardiac & Cardiovascular Systems
Guzin Surat, Dominik Bernsen, Christoph Schimmer
Summary: This study highlights the importance of antimicrobial stewardship in cardiac surgery, showcasing the success of a multidisciplinary team in minimizing adverse events through optimizing antibiotic use.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Review
Biotechnology & Applied Microbiology
Margit Mahlapuu, Camilla Bjorn, Jonas Ekblom
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2020)
Article
Medicine, Research & Experimental
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Stahlman, Jan Boren, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nystrom, Brian W. Howell, Margit Mahlapuu
Article
Biochemistry & Molecular Biology
Mara Caputo, Yeshwant Kurhe, Sima Kumari, Emmelie Cansby, Manoj Amrutkar, Eli Scandalis, Sheri L. Booten, Marcus Stahlman, Jan Boren, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Summary: This study identifies MST3 as a critical regulator of ectopic fat accumulation in human hepatocytes and shows that targeting MST3 signaling with ASOs can effectively mitigate NAFLD progression in obese mice. MST3 ASOs suppress lipogenic gene expression, reduce lipotoxicity-mediated oxidative and endoplasmic reticulum stress, and correlate with NAFLD severity in human liver biopsies. These findings suggest that MST3 inhibitors may offer a new strategy for treating NAFLD patients.
Article
Biochemistry & Molecular Biology
Gary Chinga-Carrasco, Jenny Johansson, Ellinor Baevre Heggset, Ingebjorg Leirset, Camilla Bjorn, Karin Agrenius, Jasna S. Stevanic, Joakim Hakansson
Summary: Chemical pretreatment and autoclaving altered the characteristics of cellulose nanofibrils (CNFs). In vitro tests revealed the potential application of CNFs in cytotoxicity evaluation and skin irritation assessment.
Article
Cell Biology
Margit Mahlapuu, Adam Sidorowicz, Jacek Mikosinski, Mikolaj KrzyZanowski, Jakub Orleanski, Krystyna Twardowska-Saucha, Andrzej Nykaza, Michal Dyaczynski, Beata Belz-Lagoda, Grzegorz Dziwiszek, Monika Kujawiak, Marek Karczewski, Folke Sjoberg, Tomasz Grzela, Adam Wegrzynowski, Fredrik Thunarf, Jakob Bjork, Jonas Ekblom, Arkadiusz Jawien, Jan Apelqvist
Summary: The clinical trial did not find significant differences in healing of venous lower leg ulcers between patients treated with LL-37 and the placebo overall, but a subgroup analysis indicated potential treatment benefits for patients with large ulcers, suggesting the need for further research to validate these findings.
WOUND REPAIR AND REGENERATION
(2021)
Article
Endocrinology & Metabolism
Ying Xia, Mara Caputo, Emmelie Cansby, Sumit Kumar Anand, Silva Sutt, Marcus Henricsson, Rando Porosk, Hanns-Ulrich Marschall, Matthias Bluher, Margit Mahlapuu
Summary: The study showed a positive correlation between TAOK3 mRNA expression levels and the severity of NAFLD in human liver biopsies. Overexpression of TAOK3 exacerbated lipid storage in human hepatocytes, while silencing TAOK3 attenuated lipid deposition. The findings suggest that TAOK3 plays a critical role in regulating liver lipotoxicity and susceptibility to NAFLD.
MOLECULAR METABOLISM
(2021)
Article
Gastroenterology & Hepatology
Yeshwant Kurhe, Mara Caputo, Emmelie Cansby, Ying Xia, Sima Kumari, Sumit Kumar Anand, Brian W. Howell, Hanns-Ulrich Marschall, Margit Mahlapuu
Summary: The study indicates that antagonizing STK25 signaling inhibits the development of NASH-related HCC, suggesting further analysis of STK25 as a therapeutic target for NASH-induced HCC treatment.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biology
Emmelie Cansby, Sima Kumari, Mara Caputo, Ying Xia, Rando Porosk, Jonathan Robinson, Hao Wang, Britt-Marie Olsson, Josefine Vallin, Julie Grantham, Ursel Soomets, L. Thomas Svensson, Carina Sihlbom, Hanns-Ulrich Marschall, Andreas Edsfeldt, Isabel Goncalves, Margit Mahlapuu
Summary: Silencing of STK25 reduces lipid accumulation, suppresses inflammation and fibrotic pathways, and lowers oxidative and endoplasmic reticulum stress, ultimately exerting protective effects against atherosclerosis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sumit Kumar Anand, Mara Caputo, Ying Xia, Emma Andersson, Emmelie Cansby, Sima Kumari, Marcus Henricsson, Rando Porosk, Katharina Susanne Keuenhof, Johanna Louise Hoog, Syam Nair, Hanns-Ulrich Marschall, Matthias Bluher, Margit Mahlapuu
Summary: The primary hepatic consequence of obesity is non-alcoholic fatty liver disease (NAFLD), which affects a significant proportion of the global adult population. This study investigates the potential role of STE20-type kinase MAP4K4 in the regulation of he-patocellular lipotoxicity and susceptibility to NAFLD. The findings suggest that MAP4K4 may contribute to the development of NAFLD by promoting liver lipid accumulation, inflammation, and fibrosis. Silencing MAP4K4 in human hepatocytes was found to reduce lipid deposition and alleviate oxidative/ endoplasmic reticulum stress, highlighting its potential as a therapeutic target for NAFLD.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yuning Zhang, Joakim Hakansson, Yanmiao Fan, Oliver C. J. Andren, Jorge San Jacinto Garcia, Liguo Qin, Anita Umerska, Daniel J. Hutchinson, Mads Luchow, Margit Mahlapuu, Michael Malkoch
Summary: A hybrid hierarchical delivery system for topical delivery of antimicrobial peptides (AMPs) was developed by incorporating AMPs into dendritic nanogels (DNGs) and embedding them into poloxamer gel. The system exhibited a slower release rate compared to direct entrapment in the gels, and showed good biocompatibility and strong antibacterial effects against Staphylococcus aureus.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Public, Environmental & Occupational Health
Frans Stalfelt, Karin Svensson Malchau, Camilla Bjorn, Maziar Mohaddes, Annette Erichsen Andersson
Summary: This study investigated the correlation between airborne colony-forming units (CFU) and particles during surgery, and explored the influence of different ventilation settings on this correlation. The results showed a lack of convincing evidence of correlation and suggested that particle counting may not be a substitute for conventional air bacterial assessment.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Gastroenterology & Hepatology
Ying Xia, Emma Andersson, Sumit K. Anand, Emmelie Cansby, Mara Caputo, Sima Kumari, Rando Porosk, Kalle Kilk, Syam Nair, Hanns-Ulrich Marschall, Matthias Blueher, Margit Mahlapuu
Summary: This study provides experimental evidence for the role of hepatic lipid droplet-decorating kinase TAOK1 in the development of NAFLD. The kinase affects fatty acid metabolism and distribution, as well as metabolic and pro-oncogenic signaling pathways, thus influencing the progression of NAFLD.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Margit Mahlapuu, Mara Caputo, Ying Xia, Emmelie Cansby
Summary: This review provides an overview of recent studies on the role of GCKIII kinases in NAFLD/NASH. Significant progress has been made in understanding the involvement of GCKIII kinases in hepatic fat accumulation and the progression of NAFLD, but there are still unresolved questions. More research is needed to fully understand the potential of GCKIII kinases as therapeutic targets for NAFLD and its comorbidities.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Mara Caputo, Emmelie Cansby, Sima Kumari, Yeshwant Kurhe, Syam Nair, Marcus Stahlman, Nagaraj M. Kulkarni, Jan Boren, Hanns-Ulrich Marschall, Matthias Bluher, Margit Mahlapuu
Summary: In the pathogenesis of NAFLD, MST4 is identified as a critical regulator that affects lipid accumulation by regulating beta-oxidation and triacylglycerol secretion. In addition, MST4 has been found to influence oxidative stress and endoplasmic reticulum stress in hepatocytes, indicating its potential as a therapeutic target for preventing or treating NAFLD.
HEPATOLOGY COMMUNICATIONS
(2021)
