Article
Infectious Diseases
Helio S. Sader, Cecilia G. Carvalhaes, Rodrigo E. Mendes
Summary: The study evaluated the antimicrobial activity of Ceftaroline against Staphylococcus aureus isolated from patients with infective endocarditis. Ceftaroline demonstrated potent in vitro activity against a large collection of S. aureus isolates recovered from patients with bloodstream infections, including IE. Ceftaroline susceptibility rates were higher in North America and LATAM-APAC compared to Europe.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Cheng-En Tsai, Chia-Jui Yang, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study aimed to determine the synergistic effects of combining CPT with DAP, VAN, or LNZ against different MRSA strains. The results showed that the CPT-DAP combination exhibited significant synergistic bactericidal effects, while the CPT-VAN and CPT-LNZ combinations did not show synergistic activity. Therefore, DAP may be a better choice for combination therapy with CPT in the treatment of MRSA infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Maite Villanueva, Melanie Roch, Inigo Lasa, Adriana Renzoni, William L. Kelley
Summary: This study revealed that S. aureus utilizes specific two-component environmental signal systems, ArlRS and VraSR, for defense against ceftaroline. Dual disruption of both systems resulted in a strong ceftaroline hypersensitivity phenotype, showing the potential for enhancing antibiotic efficacy by inhibiting these systems.
Article
Infectious Diseases
Deniz Gazel, Mehmet Erinmez, Ayse Buyuktas Manay, Yasemin Zer
Summary: Our investigation revealed higher rates of hVISA compared to other studies in Turkey, while both VRE agar and BHIAV screening tests failed to detect hVISA properly. The combination of meropenem and vancomycin inhibited 90% of hVISA isolates in our study.
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2021)
Article
Microbiology
Robert E. Weber, Stephan Fuchs, Franziska Layer, Anna Sommer, Jennifer K. Bender, Andrea Thurmer, Guido Werner, Birgit Strommenger
Summary: GWAS identified MprF P314L and L826F mutations as significantly associated with DAP resistance in clinical S. aureus isolates, indicating convergent evolution. Rare genetic variants were also found within mprF and putative candidate genes, while no genetic variants were associated with CPT resistance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Elias Dahdouh, Beatriz Diaz-Pollan, Iker Falces-Romero, Jesus Mingorance, Rosa Gomez-Gil
Summary: In this case, the patient had a long history of cranial surgeries and episodes of osteomyelitis, with methicillin-resistant Staphylococcus aureus showing non-susceptibility to several antibiotics. Whole-genome sequencing revealed that although the known E447K mutation for resistance to ceftobiprole and ceftaroline was not detected, mutations in other genes related to antibiotic resistance were found.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Chelsea L. Ferguson, Mallory C. Cowart, Alejandro Jordan-Villegas, Federico Laham
Summary: This case describes a pediatric patient with invasive MRSA infection who exhibited high-level ceftaroline resistance without previous exposure, underscoring the importance of considering resistance risks when initiating therapy in patients with no prior drug history.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Review
Infectious Diseases
Chienhsiu Huang, Ihung Chen, Lichen Lin
Summary: Combination therapy with daptomycin plus ceftaroline may reduce mortality in patients with methicillin-resistant Staphylococcus aureus bacteremia. The combination therapy group had similar in-hospital mortality, duration of bacteremia, and adverse event rate compared to the monotherapy group, but had lower bacteremia recurrence.
Letter
Microbiology
Lisiane da Luz Rocha Balzan, Adriana Medianeira Rossato, Cezar Vinicius Wurdig Riche, Vlademir Vicente Cantarelli, Pedro Alves D'Azevedo, Aline Valerio de Lima, Beatriz Rodrigues, Ivan Leonardo Avelino Franca e Silva, Cicero Armidio Gomes Dias, Jorge Luiz Mello Sampaio
Summary: In 2015, two new species related to Staphylococcus aureus were proposed. We report the isolation of five strains of the newly identified species, Staphylococcus argenteus, from human cases of bacteremia and skin and soft tissue infections. This is the first documentation of S. argenteus causing community-acquired and hospital-acquired infections in South America.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Daniel Ho, Nicola A. Clayton, Bruce Silverstein, Alan Koff
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia can lead to a rare eye disease called endogenous endophthalmitis (EE). Prompt diagnosis and treatment with systemic intravenous and intravitreal antibiotics are crucial to improve survival rate and prevent blindness. The management of MRSA EE is challenging as there are no established guidelines for treatment or outcomes. In this case report, we suggest that ceftaroline could be an alternative option to treat MRSA EE instead of vancomycin.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Mora N. Obed, Ines Toresani, Analia Mykietuk, Esteban C. Nannini
Summary: This study retrospectively investigated the clinical characteristics of five patients with complicated MSSA bacteremia who failed CFZ treatment but were successfully treated with CPT. The median time of CFZ therapy was 10 days, and four patients had evidence of metastatic spread while two patients had endocarditis. All patients achieved microbiological and clinical cure with CPT.
MEDICINA-BUENOS AIRES
(2022)
Article
Pharmacology & Pharmacy
Wesley D. Kufel, Katie A. Parsels, Bruce E. Blaine, Jeffrey M. Steele, Rahul Mahapatra, Kristopher M. Paolino, Stephen J. Thomas
Summary: This study aimed to evaluate the effectiveness and safety of vancomycin plus ceftaroline for persistent methicillin-resistant Staphylococcus aureus bacteremia (MRSAB). The results showed that this regimen may be an effective and well-tolerated salvage option for persistent MRSAB.
Article
Infectious Diseases
Daniele Roberto Giacobbe, Chiara Russo, Veronica Martini, Silvia Dettori, Federica Briano, Michele Mirabella, Federica Portunato, Chiara Dentone, Sara Mora, Mauro Giacomini, Marco Berruti, Matteo Bassetti
Summary: This single-center study in a large teaching hospital in Northern Italy described the use of ceftaroline in COVID-19 patients, with a focus on MRSA-BSI cases. Ceftaroline showed promising rates of favorable response in treating MRSA-BSI, either as monotherapy or in combination with other anti-MRSA agents. Improved etiological diagnosis of bacterial infections is crucial for optimizing ceftaroline use in COVID-19 patients.
Review
Immunology
Daniel J. Minter, Ayesha Appa, Henry F. Chambers, Sarah B. Doernberg
Summary: This review aims to provide a comprehensive overview of the evaluation and management of Staphylococcus aureus bacteremia, with a special focus on areas where the highest level of evidence is lacking to inform best practices.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Benjamin Russakoff, Colin Wood, Monica R. Lininger, Steven D. Barger, Robert T. Trotter, Sara Maltinsky, Mimi Mbegbu, Briana Coyne, David Panisello Yaguee, Shari Kyman, Kara Tucker-Morgan, Kathya Ceniceros, Cristina Padilla, Kevin Hurtado, Ashley Menard, Francisco Villa, Heidi A. Wayment, Crystal Hepp, Tara Furstenau, Viacheslav Fofanov, Cindy M. Liu, Talima R. Pearson
Summary: This study provides new insights into S aureus carriage by assessing pathogen load and prevalence. The results suggest that current detection and understanding of carriage may be inaccurate, which hinders effective infection mitigation.
JOURNAL OF INFECTIOUS DISEASES
(2023)