Article
Infectious Diseases
Alicia Rodriguez-Gascon, Amaia Aguirre-Quinonero, Maria Angeles Solinis Aspiazu, Andres Canut-Blasco
Summary: PK/PD analysis showed that tedizolid has a high probability of treatment success for most staphylococci, enterococci, and streptococci causing ABSSSI, even for those linezolid-resistant strains mediated by the cfr gene.
Article
Immunology
Russell R. Kempker, Alison G. C. Smith, Teona Avaliani, Mariam Gujabidze, Tinatin Bakuradze, Shorena Sabanadze, Zaza Avaliani, Jeffrey M. Collins, Henry M. Blumberg, Mohammad H. Alshaer, Charles A. Peloquin, Maia Kipiani
Summary: This study fills a critical knowledge gap regarding the ability of antituberculosis drugs to penetrate into the cerebrospinal fluid (CSF) and provides valuable pharmacokinetic data for the treatment of tuberculosis meningitis (TBM). Linezolid and cycloserine showed moderate to high CSF penetration and may be effective drugs for TBM treatment, while the efficacy of bedaquiline, delamanid, and clofazimine remains uncertain due to their low CSF penetration.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Yuichi Shibata, Mao Hagihara, Nobuhiro Asai, Arufumi Shiota, Jun Hirai, Nobuaki Mori, Hiroshige Mikamo
Summary: Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotics used for meticillin-resistant Staphylococcus aureus (MRSA) infections. Severe hyponatremia has been reported after LZD administration, leading to seizures, unconsciousness, and death. In this study, we compared the effects of LZD and TZD on serum sodium levels and found that hyponatremia was more common in the LZD group (39.7%) compared to the TZD group (11.1%). Logistic regression analysis identified albumin levels as a risk factor for hyponatremia. Our findings suggest that TZD is safer than LZD in terms of hyponatremia, and LZD injections should be used with caution in patients with low albumin levels.
Article
Biochemical Research Methods
Mohd Abul Kalam, Muzaffar Iqbal, Abdullah Alshememry, Musaed Alkholief, Aws Alshamsan
Summary: A sensitive UPLC-MS/MS analytical method was developed and validated for the quantification of TDZ in rabbit?s aqueous humor. The method was linear in the concentration range, sensitive and reliable, and successfully employed for ocular pharmacokinetic study of TDZ after topical ocular application of TZP-containing formulations in rabbit eyes.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Microbiology
Masakazu Shibata, Masatoshi Masuda, Katsunori Sasahara, Hiroyuki Sasabe, Tomohiro Sasaki, Seongryul Kim, Kenji Takeuchi, Ken Umehara, Eiji Kashiyama
Summary: Delamanid has been extensively studied and approved for the treatment of pulmonary multidrug-resistant tuberculosis. This study investigated the potential of delamanid in treating extrapulmonary tuberculosis by simulating its pharmacokinetic profile in various tissues. The results suggest that delamanid may achieve concentrations in extrapulmonary organs similar to that of the lung, indicating its potential for treating extrapulmonary tuberculosis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Krzysztof Lukaszuk, Amira Podolak
Summary: This retrospective case control study found that mtDNA copy number is higher in aneuploid embryos compared to euploid embryos, but no significant differences were observed in relation to embryo morphology, genetic sex, maternal age, or implantation ability. Therefore, mtDNA has the potential to serve as an additional independent biomarker for embryo selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Nikunjkumar K. Patel, Kuan-Fu Chen, Shang-Chiung Chen, Kai Liu
Summary: This study developed a model based on in vitro and clinical PK data to evaluate the role of Sparsentan as both a perpetrator and victim of CYP3A4 mediated drug-drug interactions. The predictive simulations showed that Sparsentan exposure could increase more than two-fold when co-administered with a strong CYP3A4 inhibitor, such as itraconazole.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Toxicology
Claude Emond, Luc Multigner
Summary: This study developed a physiologically based pharmacokinetic (PBPK) model in rats and extrapolated it to humans, aiming to improve health risk assessments for CD contamination and reassess toxicological reference values.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Chemistry, Analytical
Ryota Tanaka, Makoto Kai, Koji Goto, Yoshifumi Ohchi, Norihisa Yasuda, Ryosuke Tatsuta, Takaaki Kitano, Hiroki Itoh
Summary: This study developed a high-throughput and wide-range method for simultaneous quantification of LZD, DAP, and TZD in human plasma. Using UPLCMS/MS, the method met the requirements for bioanalytical method validation, demonstrating good linearity and accuracy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Huan Yang, Wanda van der Stel, Randy Lee, Caroline Bauch, Sam Bevan, Paul Walker, Bob van de Water, Erik H. J. Danen, Joost B. Beltman
Summary: Mitochondria are the main bioenergetic organelles of cells and exposure to chemicals targeting mitochondria generally results in toxicity. Different mitochondrial respiration inhibitors have varying effects on mitochondrial membrane potential, and mathematical modeling can help understand these dynamics. Additionally, incorporating pharmacokinetic decay into the model can improve the fit for certain compounds, showing a complex interplay between pharmacokinetics and MMP dynamics within mitochondria.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongrui Liu, Yiqun Yu, Lu Liu, Chunyan Wang, Nan Guo, Xiaojuan Wang, Xiaoqiang Xiang, Bing Han
Summary: The aim of this study was to evaluate the effect of pharmacokinetic changes on the antihypertensive effect of nifedipine caused by the co-administration with apatinib. The results showed that the exposure changes of nifedipine caused by combination with apatinib had little impact on the changes of systolic blood pressure. Therefore, nifedipine could be used in combination with apatinib without dose adjustment in clinic.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Brittany P. P. Rickard, Marta Overchuk, Vesna A. A. Chappell, Mustafa Kemal Ruhi, Prima Dewi Sinawang, Tina Thuy Nguyen Hoang, Demir Akin, Utkan Demirci, Walfre Franco, Suzanne E. E. Fenton, Janine H. H. Santos, Imran Rizvi
Summary: This review discusses methods to evaluate the structural and functional parameters of mitochondrial health in the context of tumors and cancer cells. By leveraging these techniques, insights can be gained into the biology, metastatic potential, and response to therapy of tumors, ultimately leading to improved treatment plans.
Article
Multidisciplinary Sciences
Themis Thoudam, Dipanjan Chanda, Ibotombi Singh Sinam, Byung-Gyu Kim, Mi-Jin Kim, Chang Joo Oh, Jung Yi Lee, Min-Ji Kim, Soo Yeun Park, Shin Yup Lee, Min-Kyo Jung, Ji Young Mun, Robert A. Harris, Naotada Ishihara, Jae-Han Jeon, In-Kyu Lee
Summary: The study reveals that PDK4 plays a crucial role in promoting rapid mitochondrial fragmentation in response to ETC toxins, and overexpression of PDK4 can induce mitochondrial fission even in the absence of mitochondrial stress. The investigation also identifies SEPT2 as a key effector molecule for PDK4 to regulate mitochondrial fission through DRP1 at the interface of cellular bioenergetics and mitochondrial dynamics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Infectious Diseases
Carlijn H. C. Litjens, Laurens F. M. Verscheijden, Elin M. Svensson, Petra H. H. van den Broek, Hedwig van Hove, Jan B. Koenderink, Frans G. M. Russel, Rob E. Aarnoutse, Lindsey H. M. te Brake
Summary: This study developed a PBPK model to predict the concentration of linezolid in cranial cerebrospinal fluid (CSF) and assess its pharmacodynamic (PD) thresholds attainment in adults and children with tuberculous meningitis. The results showed that a dose of 1200 mg per day in adults and similar to 10 mg/kg BID in children could achieve reasonable target attainment in cranial CSF.
Article
Pharmacology & Pharmacy
Jinying Zhu, Yuqing Zhao, Lu Wang, Chen Zhou, Sufeng Zhou, Tao Chen, Juan Chen, Zeru Zhang, Ying Zhu, Sijia Ding, Feng Shao
Summary: The study aimed to develop a PBPK/PD model for midazolam rectal gel, ensure the PK/PD behavior in healthy adults, identify key factors for absorption, and support future clinical studies. Based on simulations, the recommended maximum dose is 15 mg, and a retention time longer than 3 hours is needed for optimal effects.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Microbiology
Jacob W. Snowdin, Chia-Heng Hsiung, Daniel G. Kesterson, Vasudeva G. Kamath, Edward E. McKee
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Microbiology
Matthew D. Lynx, Darcy D. LaClair, Edward E. McKee
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2009)
Article
Infectious Diseases
Gerald W. Morris, Darcy D. LaClair, Edward E. McKee
Article
Biochemistry & Molecular Biology
Gerald W. Morris, Tyler A. Iams, Kira G. Slepchenko, Edward E. McKee
BIOCHEMICAL JOURNAL
(2009)
Article
Pharmacology & Pharmacy
Matthew D. Lynx, Bae-Kwang Kang, Edward E. Mckee
BIOCHEMICAL PHARMACOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Vasudeva G. Kamath, Chia-Heng Hsiung, Zachary J. Lizenby, Edward E. McKee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Peter McHenry, Wei-Lin Winnie Wang, Edward Devitt, Nicholas Kluesner, Vincent Jo Davisson, Edward McKee, Dirk Schweitzer, Paul Helquist, Martin Tenniswood
JOURNAL OF CELLULAR BIOCHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Kathleen A. McCann, David W. Williams, Edward E. McKee
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Multidisciplinary Sciences
Jinxiang Xi, Xiuhua A. Si, JongWon Kim, Edward Mckee, En-Bing Lin
Article
Toxicology
Ofelia A. Olivero, Irma L. Vazquez, Catherine C. Cooch, Jessica Ming, Emily Keller, Mia Yu, Jennifer P. Borojerdi, Hannan M. Braun, Edward McKee, Miriam C. Poirier
TOXICOLOGICAL SCIENCES
(2010)
Article
Emergency Medicine
Michael W. Donnino, Joseph Miller, A. Joseph Garcia, Edward Mckee, Mark Walsh
ANNALS OF EMERGENCY MEDICINE
(2007)
Article
Microbiology
Delia Susan-Resiga, Alice T. Bentley, Matthew D. Lynx, Darcy D. LaClair, Edward E. McKee
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2007)
Article
Pharmacology & Pharmacy
Matthew D. Lynx, Edward E. McKee
BIOCHEMICAL PHARMACOLOGY
(2006)
Article
Microbiology
EE McKee, M Ferguson, AT Bentley, TA Marks
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2006)