期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 58, 期 9, 页码 5572-5575出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03154-14
关键词
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资金
- Italian Cystic Fibrosis Research Foundation [FFC 14/2010]
- Italian Ministry of University and Research-PRIN [2012WJSX8K]
Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)(3) in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.
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