Nitro/Nitrosyl-Ruthenium Complexes Are Potent and Selective Anti-Trypanosoma cruzi Agents Causing Autophagy and Necrotic Parasite Death

Antiparasitic activities of novel ruthenium/lapachol complexes

(2014) Marília I.F. Barbosa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Chagas disease: control, elimination and eradication. Is it possible?

(2014) Jose Rodrigues Coura   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Unveiling Benznidazole's mechanism of action through overexpression of DNA repair proteins inTrypanosoma cruzi

(2013) Matheus Andrade Rajão et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells

(2013) Eva Iniguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice

(2013) J. M. Bustamante et al.   JOURNAL OF INFECTIOUS DISEASES

New ruthenium(II)/phosphines/diimines complexes: Promising antitumor (human breast cancer) and Mycobacterium tuberculosis fighting agents

(2013) Edjane R. dos Santos et al.   POLYHEDRON

Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi

(2012) Phercyles Veiga-Santos et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains

(2012) Sabrina Cencig et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Searching for New Chemotherapies for Tropical Diseases: Ruthenium–Clotrimazole Complexes Display High in Vitro Activity against Leishmania major and Trypanosoma cruzi and Low Toxicity toward Normal Mammalian Cells

(2012) Alberto Martínez et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics

(2012) Annie Castonguay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

(2011) Belinda S. Hall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigation on the pharmacological profile of antimony(III) complexes with hydroxyquinoline derivatives: anti-trypanosomal activity and cytotoxicity against human leukemia cell lines

(2011) Débora C. Reis et al.   BIOMETALS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Ruthenium(II) phosphine/diimine/picolinate complexes: Inorganic compounds as agents against tuberculosis

(2011) Fernando R. Pavan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A new nitrosyl ruthenium complex: Synthesis, chemical characterization, in vitro and in vivo antitumor activities and probable mechanism of action

(2011) Tassiele A. Heinrich et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin

(2011) Michael Groessl et al.   Metallomics

Biological activity of ruthenium nitrosyl complexes

(2011) Elia Tfouni et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion

(2011) Patricia S. Doyle et al.   PLoS Pathogens

Tolerance of Benznidazole in Treatment of Chagas' Disease in Adults

(2010) M.-J. Pinazo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity

(2010) Jean Jerley Nogueira Silva et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitric oxide donor trans-[RuCl([15]aneN4)NO]2+ as a possible therapeutic approach for Chagas' disease

(2010) Paulo MM Guedes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Risedronate metal complexes potentially active against Chagas disease

(2010) Bruno Demoro et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: New achievements

(2010) Julio Benítez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Nuclear Permeable Ruthenium(II) β-Carboline Complexes Induce Autophagy To Antagonize Mitochondrial-Mediated Apoptosis

(2010) Caiping Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo experimental models for drug screening and development for Chagas disease

(2010) Alvaro José Romanha et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches

(2009) Julio A. Urbina   ACTA TROPICA

Experimental Chemotherapy against Trypanosoma cruzi Infection Using Ruthenium Nitric Oxide Donors

(2009) J. J. N. Silva et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure–activity relationships

(2009) Claudio Luis Donnici et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Cytotoxic Ruthenium Tris(Bipyridyl) Complex that Accumulates at Plasma Membranes

(2009) Olivier Zava et al.   CHEMBIOCHEM

Electron Microscopy in Antiparasitic Chemotherapy: A (Close) View to a Kill

(2009) M. Vannier-Santos et al.   CURRENT DRUG TARGETS

Approaches for the Development of New Anti-Trypanosoma cruzi Agents

(2009) Diogo Rodrigo Magalhaes Moreira et al.   CURRENT DRUG TARGETS

Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites

(2009) Alessio Bocedi et al.   FASEB JOURNAL

Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase

(2008) Marisol Vieites et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Natural programmed cell death inT. cruziepimastigotes maintained in axenic cultures

(2008) V. Jimenez et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Complexation of the anti-Trypanosoma cruziDrug Benznidazole Improves Solubility and Efficacy

(2008) Jean Jerley Nogueira Silva et al.   JOURNAL OF MEDICINAL CHEMISTRY