Article
Nutrition & Dietetics
Minchun Zhang, Jie Chen, Minglan Yang, Cheng Qian, Yu Liu, Yicheng Qi, Rilu Feng, Mei Yang, Wei Liu, Jing Ma
Summary: This study investigated the effects of lower doses of sucralose on fecal microbiota in obesity and found that 0.54 mM and 0.78 mM sucralose can affect beneficial bacteria. Different dosages of sucralose may alter the compositions of fecal microbiota.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Natalia Rukoyatkina, Valentina Shpakova, Julia Sudnitsyna, Michael Panteleev, Stephanie Makhoul, Stepan Gambaryan, Kerstin Jurk
Summary: Our study demonstrated that curcumin exerts inhibitory effects on platelets through promoting procoagulant platelet formation instead of platelet apoptosis. Additionally, curcumin induced autophagy in platelets and inhibited platelet P-glycoprotein activity, contributing to its inhibitory effect on platelets through complex processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agronomy
Luka Milosevic, O. Adewale Osipitan, Jon E. Scott, Stevan Z. Knezevic
Summary: The widespread use of dicamba in the United States increased off-target movement to susceptible vegetations. However, there is no evidence that ultra-low doses of dicamba enhance soybean growth and yield, regardless of the application timing. Efforts should be made to avoid dicamba drift to susceptible soybean as there is no evidence of enhanced growth and yield with the ultra-low doses.
Article
Infectious Diseases
Maria V. Golikova, Elena N. Strukova, Kamilla N. Alieva, Vladimir A. Ageevets, Alisa A. Avdeeva, Ofeliia S. Sulian, Stephen H. Zinner
Summary: The minimal inhibitory concentration (MIC) is used to determine bacterial susceptibility or resistance to antibiotics and predict clinical efficacy. Other measures of resistance include the MIC determined at high bacterial inocula (MICHI) and the mutant prevention concentration (MPC). This study analyzed the resistance profiles of different K. pneumoniae strains based on meropenem susceptibility, carbapenemase production, and specific carbapenemase types. The analysis showed that MIC and MPC did not correlate, but there was a significant correlation between MICHI and MPC, indicating similar resistance properties. Determining MICHI can help assess the resistance-related risk of a specific K. pneumoniae strain.
Article
Oncology
Douglas Magno Guimaraes, Tamara Melo Nunes Ota, Diego Assuncao Calixto Da Silva, Fabio De Lucas Da Silva Almeida, Tatiana Dias Schalch, Alessandro Melo Deana, Jose Miguel Alves Junior, Kristianne Porta Santos Fernandes
Summary: This study compared the efficacy of LLLT and LEDT for prevention and treatment of oral mucositis, finding that LEDT has similar effects to LLLT in reducing symptoms of oral mucositis. Therefore, LEDT could be considered as an alternative option for preventing and treating oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Acoustics
Sabine Thomassen, Kevin Hartung, Wolfgang Einhaeuser, Alexandra Bendixen
Summary: Frequency separation has an effect on integrated and segregated percepts in sequential auditory scene analysis, but asymmetry exists between different tone patterns at sequence onset.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Pediatrics
Surendra Babu Gundluru, Pritam Singha Roy, Manisha Biswal, Amita Trehan, Jasleen Kaur, Pallab Ray, Deepak Bansal
Summary: This prospective study examined the use of surveillance stool culture (SSC) in febrile neutropenia (FN) in children with acute leukemia. The study found a prevalence of 17.5% multidrug-resistant organisms (MDRO) in the first SSCs, but no correlation between MDRO colonization and mortality. MDRO colonization did not predict MDRO sepsis, bloodstream infection, or mortality. Therefore, SSC was found to be ineffective in guiding antibiotic choice for FN in children with acute leukemia.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Surgery
Devansh Shah, Angelina Di Re, James W. T. Toh
Summary: In this study, high-dose aspirin (500-1200 mg/day) was found to be associated with a reduction in colorectal cancer incidence, whereas mid-dose (164-325 mg/day) and low-dose (50-163 mg/day) aspirin may not have a protective effect.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Engineering, Environmental
He Wang, Dustin Knabe, Irina Engelhardt, Bjoern Droste, Hans-Peter Rohns, Christine Stumpp, Johannes Ho, Christian Griebler
Summary: Riverbank filtration is an important method for obtaining high-quality raw water for drinking water production. This study examined the removal of adenovirus during different river levels and compared it with commonly used bacterial and viral water quality indicators. The results showed that the highest removal efficiency of adenovirus and other indicators was achieved during high river levels. However, during low river levels, there was occasional presence of coliforms and C. perfringens in the raw water. Therefore, a combination of E. coli, coliforms, and somatic coliphages can be used to assess riverbank filtration performance in adenovirus removal.
Article
Nutrition & Dietetics
Ana Paula Renno Sierra, Antonio Alves Fontes-Junior, Ines Assis Paz, Cesar Augustus Zocoler de Sousa, Leticia Aparecida da Silva Manoel, Duane Cardoso de Menezes, Vinicius Alves Rocha, Hermes Vieira Barbeiro, Heraldo Possolo de Souza, Maria Fernanda Cury-Boaventura
Summary: Inadequate nutrient intakes, such as low carbohydrate and calcium intakes, are associated with higher fat mass. High sucrose and sodium intakes are associated with elevated levels of BDNF. Adequate carbohydrate intake after exercise promotes higher levels of myostatin and musclin, while inadequate intakes lead to lower levels of IL-15 and BDNF. High cholesterol and low fiber intakes are associated with lower levels of irisin and apelin.
Article
Agriculture, Dairy & Animal Science
Suran Liu, Ziwei Wei, Ming Deng, Zhenyu Xian, Dewu Liu, Guangbin Liu, Yaokun Li, Baoli Sun, Yongqing Guo
Summary: Fat content is important for milk quality, but it can be affected by diet composition. Feeding cows with high-starch or high-fat diets can lead to a reduction in milk fat synthesis. This study found that high-starch or high-fat feeding can induce milk fat depression in dairy cows and also affect hindgut fermentation and fiber digestibility.
Article
Multidisciplinary Sciences
Mekdes Alemu Tola, Negga Asamene Abera, Yonas Mekonnen Gebeyehu, Surafel Fentaw Dinku, Kassu Desta Tullu
Summary: This study in Addis Ababa, Ethiopia, found a high prevalence of ESBL producing Escherichia coli and Klebsiella pneumoniae fecal carriage among children under five, with high levels of multidrug resistance. Factors associated with higher ESBL carriage included lower maternal education and drinking tap water. Routine screening for ESBL is crucial for early detection and appropriate antibiotic selection.
Article
Multidisciplinary Sciences
Mekdes Alemu Tola, Negga Asamene Abera, Yonas Mekonnen Gebeyehu, Surafel Fentaw Dinku, Kassu Desta Tullu
Summary: The prevalence of ESBL producing E. coli and K. pneumoniae fecal carriage among children under five years in Addis Ababa, Ethiopia was found to be 17.1%. These isolates showed high levels of multidrug resistance and were associated with lower educational level of mothers and drinking tap water in children. Routine screening for ESBL is crucial for early detection and appropriate antibiotic selection.
Article
Food Science & Technology
Shuhua Tian, Xiangfei Li, Yunfan Wang, Yingjian Lu
Summary: In this study, administration of different dosages of Sulforaphane (SFN) showed positive effects on insulin levels, blood glucose, liver health and pancreatic tissue repair, as well as modulation of gut microbiota. SFN increased liver antioxidant capacities and reduced serum lipopolysaccharide levels, while altering the relative abundance of certain bacterial groups in the gut.
FOOD SCIENCE & NUTRITION
(2021)
Article
Marine & Freshwater Biology
Jessy Le Du-Carree, Thierry Morin, Morgane Danion
Summary: The study found that exposure of rainbow trout to a concentration of 1 mu g L-1 of glyphosate for 10 months did not significantly impact their overall health, including during the spawning period, regardless of whether the pure active substance or two GBH formulations were used. However, immunological disturbances observed may require further investigation as they could have a significant impact in response to infectious stress.
AQUATIC TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
JingJing Liu, Jean-Yves Madec, Alain Bousquet-Melou, Marisa Haenni, Aude A. Ferran
Summary: Non-antibiotic substances subtilisin A and calcium gluconate were found to significantly reduce the biomass of S. aureus biofilms, while antibiotics alone had limited effects. Combining antibiotics with calcium gluconate or subtilisin A led to an additive reduction of embedded biofilm bacteria in susceptible isolates. Further studies are needed to understand factors contributing to susceptibility to these combinations in specific isolates.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Quentin Valle, Beatrice B. Roques, Alain Bousquet-Melou, David Dahlhaus, Felipe Ramon-Portugal, Veronique Dupouy, Delphine Bibbal, Aude A. Ferran
Summary: Minocycline shows potential activity against multidrug-resistant bacteria, but may impact gut microbiota during treatment. Research found that minocycline concentrations in the intestines were higher than in plasma, but its activity in large intestine content was lower than in a standard broth.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemical Research Methods
Cindy Dierikx, Stefan Borjesson, Agnes Perrin-Guyomard, Marisa Haenni, Madelaine Norstrom, Hege H. Divon, Hanna Karin Ilag, Sophie A. Granier, Annette Hammerum, Jette Sejer Kjeldgaard, Natalie Pauly, Luke Randall, Muna F. Anjum, Aleksandra Smialowska, Alessia Franco, Kees Veldman, Jannice Schau Slettemeas
Summary: The study evaluated the performance of different commercially available selective agars for the detection of carbapenemase producing Enterobacteriaceae (CPE). Most agars performed well, but it is important to consider different types of CPE strains when choosing agar type.
JOURNAL OF MICROBIOLOGICAL METHODS
(2022)
Article
Veterinary Sciences
Maria D. Vegas Comitre, Stefano Cortellini, Marc Cherlet, Mathias Devreese, Beatrice B. Roques, Alain Bousquet-Melou, Pierre-Louis Toutain, Ludovic Pelligand
Summary: This study investigated the pharmacokinetics of amoxicillin-clavulanic acid in healthy and critically ill dogs, finding significant differences in drug clearance between the two populations. The results suggested potential adjustments to dosing regimens in clinical settings for sick dogs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Agnes Perrin-Guyomard, Sophie A. Granier, Jannice Schau Slettemeas, Muna Anjum, Luke Randall, Manal AbuOun, Natalie Pauly, Alexandra Irrgang, Jens Andre Hammerl, Jette Sejer Kjeldgaard, Anette Hammerum, Alessia Franco, Magdalena Skarzynska, Ewelina Kaminska, Dariusz Wasyl, Cindy Dierikx, Stefan Borjesson, Yvon Geurts, Marisa Haenni, Kees Veldman
Summary: This study evaluated the performance of a screening protocol to detect and isolate mcr-positive Escherichia coli and Salmonella spp. from animal caecal content and meat samples. The results showed that the combined method was effective in detecting and isolating E. coli or Salmonella spp. strains harboring different mcr genes, and could potentially be used as a harmonized protocol for screening mcr genes in food-producing animals and food products in Europe.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Aurore Perault, Catherine Turlan, Nathalie Eynard, Quentin Valle, Alain Bousquet-Melou, Etienne Giraud
Summary: Recent studies have shown that both resistance and tolerance/persistence levels can evolve rapidly in bacteria exposed to repeated antibiotic treatments. This study used in vitro evolution to explore the selection of tolerant/hyperpersistent Escherichia coli mutants under repeated exposure to high ciprofloxacin concentration. The researchers found that mutants with hyperpersistence specific to fluoroquinolones emerged, without a significant increase in minimum inhibitory concentration. This research highlights the importance of considering tolerance/persistence phenotypes in addition to resistance in antibiotic therapy selection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Cristina Santos-Santorum Suarez, Pascal Sanders, Agnes Perrin-Guyomard, Dominique Hurtaud-Pessel, Michel Laurentie, Alexis Viel, Jean-Francois Taillandier, Marie-Pierre Lagree, Murielle Gaugain
Summary: Cross-contamination between medicated and non-medicated feed can lead to the presence of low concentrations of antibiotics in animal feed, posing potential risks to consumers and the emergence of resistant bacteria.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Agriculture, Dairy & Animal Science
Abubakar Bello, Jerome Henri, Alexis Viel, Jonathan Paul Mochel, Blazej Pozniak
Summary: Poultry production is associated with the use of veterinary medicinal products to manage diseases. Ionophore coccidiostats, although prohibited for use in laying hens, are frequently found in commercial poultry eggs. Various factors influence the presence of residues in eggs, with the carryover of coccidiostats from feed to laying hens being the main reason. This paper reviews the causes of residue occurrence and highlights the potential application of pharmacokinetic modeling for predicting residue transfer in eggs.
Article
Microbiology
Aude A. Ferran, Marlene Z. Lacroix, Ophelie Gourbeyre, Alicia Huesca, Baptiste Gaborieau, Laurent Debarbieux, Alain Bousquet-Melou
Summary: The development of antibiotic resistance in bacteria compromises the effectiveness of antibiotics and bacteriophages. This study demonstrates that combining phages with antibiotics can prevent the growth of resistant clones.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
Felipe Ramon Portugal, Marlene Z. Lacroix, Beatrice B. Roques, Veronique Gayrard, Pierre-Louis Toutain, Alain Bousquet-Melou
Summary: Doxycycline, an antibiotic commonly used in pig farming, has been found to have a higher free fraction than previously estimated. The protein binding of doxycycline in pig plasma was measured using an equilibrium dialysis method and found to have a mean fu value of 31%. This new data has implications for the calculation of PK/PD cut-offs used in antimicrobial susceptibility testing.
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Pierre-Louis Toutain, Peggy Gandia, Ludovic Pelligand, Aude A. Ferran, Peter Lees, Alain Bousquet-Melou, Didier Concordet
Summary: The confusion between free concentration and unbound fraction in medical literature has led to biased computations, erroneous interpretations, and misleading recommendations. This paper highlights these problems in the context of calculating Probability of Target Attainment (PTA), which is used for interpreting Antimicrobial Susceptibility Testing. The use of total plasma concentrations scaled by the unbound fraction inevitably results in biased estimates, especially when the variability associated with the unbound fraction is added instead of removed.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
(2023)
Article
Toxicology
Mathias Freville, Jerome Henri, Anthony Estienne, Loise Serra, Christelle Rame, Patrice Ganier, Marine Chahnamian, Pascal Froment, Joelle Dupont
Summary: This study provides new data on the elimination rate and approximate biological half-life range of glyphosate in birds, showing that glyphosate-based herbicides are quickly eliminated from plasma in birds and are poorly distributed.
TOXICOLOGY LETTERS
(2023)
Article
Microbiology
Elodie A. Lallemand, Alain Bousquet-Melou, Laura Chapuis, Jennifer Davis, Aude A. Ferran, Butch Kukanich, Taisuke Kuroda, Marlene Z. Lacroix, Yohei Minamijima, Lena Olsen, Ludovic Pelligand, Felipe Ramon Portugal, Beatrice B. Roques, Elizabeth M. Santschi, Katherine E. Wilson, Pierre-Louis Toutain
Summary: This study aimed to establish a species-specific Clinical Breakpoint for interpretation of Antimicrobial Susceptibility Testing of benzylpenicillin (BP) in horses. A population pharmacokinetic model was developed to compute PK/PD cutoff values of different BP formulations commonly used in equine medicine globally.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Emmanuelle Totain, Loic Lindner, Nicolas Martin, Yolande Misseri, Alexandra Iche, Marie-Christine Birling, Tania Sorg, Yann Herault, Alain Bousquet-Melou, Pascale Bouille, Christine Duthoit, Guillaume Pavlovic, Severine Boullier
Summary: This study used C216 candidate therapeutic vaccine to validate its efficacy in mouse and dog models for HPV infections. Animal models with easily transposable genetic design were developed to evaluate candidate vaccines. Results showed that although C216 vaccine had strong immunogenicity, it did not induce a sufficiently strong immune response to eliminate infected cells.
LABORATORY ANIMAL RESEARCH
(2023)