Protein-Free Efavirenz Concentrations in Cerebrospinal Fluid and Blood Plasma Are Equivalent: Applying the Law of Mass Action To Predict Protein-Free Drug Concentration

Low Cerebrospinal Fluid Concentrations of the Nucleotide HIV Reverse Transcriptase Inhibitor, Tenofovir

(2012) Brookie M. Best et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

Overton's Rule Helps To Estimate the Penetration of Anti-Infectives into Patients' Cerebrospinal Fluid

(2011) Marija Djukic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Male Genital Tract Is Not a Pharmacological Sanctuary From Efavirenz

(2011) L B Avery et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

(2011) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characteristics of HIV-1 Serodiscordant Couples Enrolled in a Clinical Trial of Antiretroviral Pre-Exposure Prophylaxis for HIV-1 Prevention

(2011) Andrew Mujugira et al.   PLoS One

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

(2010) R. Nau et al.   CLINICAL MICROBIOLOGY REVIEWS

Efavirenz concentrations in CSF exceed IC50 for wild-type HIV

(2010) B. M. Best et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A highly sensitive ultra performance liquid chromatography–tandem mass spectrometric (UPLC–MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma

(2010) Lindsay B. Avery et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men

(2010) Robert M. Grant et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic

(2009) Samuel Broder   ANTIVIRAL RESEARCH

Low atazanavir concentrations in cerebrospinal fluid

(2008) Brookie M Best et al.   AIDS

Validation of the CNS Penetration-Effectiveness Rank for Quantifying Antiretroviral Penetration Into the Central Nervous System

(2008) Scott Letendre   ARCHIVES OF NEUROLOGY

Antiretroviral Treatment of Adult HIV Infection

(2008) Scott M. Hammer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Impact of pH on Plasma Protein Binding in Equilibrium Dialysis

(2008) Christopher J. Kochansky et al.   MOLECULAR PHARMACEUTICS