期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 9, 页码 4532-4534出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00491-13
关键词
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资金
- Spanish Ministry of Science and Innovation [BIO 2010-20204, PRI-PIBIN-2011-0915, BFU2011-14145-E]
- EU FP7 Marie Curie Action ITN [289285]
- EU FP7 Health Project EvoTAR
- Comunidad de Madrid (Spain) [2009 AGR/4189]
Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as ST11, a human epidemic clone reported worldwide and associated with, among others, OXA-48 and NDM carbapenemases. In the seven strains, armA was borne by an IncR plasmid, pB1025, of 50 kb. The isolates were found to coproduce DHA-1 and SHV-11 beta-lactamases, as well as the QnrB4 resistance determinant. This first report of the ArmA methyltransferase in pets illustrates their importance as a reservoir for human multidrug-resistant K. pneumoniae.
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