Article
Microbiology
Mingxing Yang, Dong Liu, Xiaoquan Li, Chuting Xiao, Yingge Mao, Jiaqi He, Jiao Feng, Li Wang
Summary: Gram-negative bacteria producing extended-spectrum beta-lactamase (ESBL) are common and pose a significant threat in both community and hospital settings. This study examined a strain of Escherichia coli isolated from a 7-day-old infant's blood in China, which carried multiple ESBL genes and drug resistance plasmids. The findings suggest that these bacteria are highly resistant to antibiotics and capable of maintaining resistance through chromosomal location of the ESBL genes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebecca Devine, Hannah P. McDonald, Zhiwei Qin, Corinne J. Arnold, Katie Noble, Govind Chandra, Barrie Wilkinson, Matthew Hutchings
Summary: The study identified promising antibiotics formicamycins, and showed that understanding the regulation of the biosynthetic gene cluster can increase production levels and induce the production of additional congeners.
CELL CHEMICAL BIOLOGY
(2021)
Article
Infectious Diseases
Yujie Hu, Seamus Fanning, Scott Nguyen, Wei Wang, Chang Liu, Xinnan Cui, Yinping Dong, Xin Gan, Jin Xu, Fengqin Li
Summary: CFSA629, a MDR S. Typhimurium ST34 isolate from China, carries a novel mcr-1.19 variant on an IncHI2 plasmid, highlighting the importance of surveillance to prevent the spread of mcr genes among foodborne Salmonella. Improved surveillance is crucial in controlling the dissemination of mcr genes worldwide.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Letter
Immunology
Cong Shen, Lan-Lan Zhong, Zhijuan Zhong, Yohei Doi, Jianzhong Shen, Yang Wang, Furong Ma, Mohamed Abd El-Gawad El-Sayed Ahmed, Guili Zhang, Yong Xia, Cha Chen, Guo-Bao Tian
Summary: China banned the use of colistin in livestock fodders in response to the spread of the colistin resistance gene mcr-1. A time-series analysis of inpatient colonization data from 2011-2019 accurately revealed fluctuations in mcr-1 among inpatients in response to the ban.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Aurelie Ferrand, Julia Vergalli, Claude Bosi, Alix Pantel, Jean-Marie Pages, Anne Davin-Regli
Summary: The emergence of MDR strains poses a public health problem. The role of antibiotic efflux in bacterial resistance is often underestimated, leading to misinterpretation of resistance phenotypes. We developed a diagnostic system to quantify efflux and improve patient management.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Fengtian Li, Kun Ye, Xin Li, Liyan Ye, Ling Guo, Lifeng Wang, Jiyong Yang
Summary: This study investigated 144 carbapenem-resistant Escherichia coli (CREco) isolates from 10 cities in China, finding that the majority belonged to ST167, followed by ST410 and ST131; most of them carried various NDM-coding genes, with some ST types showing an outbreak trend.
Article
Immunology
Agustina Costa, Roque Figueroa-Espinosa, Florencia Gaudenzi, Nilton Lincopan, Bruna Fuga, Barbara Ghiglione, Gabriel Gutkind, Jose Di Conza
Summary: This study describes the first clinical isolate of NDM-5- and RmtB-producing Escherichia coli in Latin America, displaying resistance to multiple antibiotics. The co-transfer of resistance genes located on conjugative plasmids poses a challenge for clinical treatment, and the spread of pathogens resistant to last resort antibiotics should raise an alarm in the healthcare system worldwide.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Baoli Chen, Bjorn Berglund, Shuang Wang, Stefan Borjesson, Zhenqiang Bi, Maud Nilsson, Hong Yin, Beiwen Zheng, Yonghong Xiao, Zhenwang Bi, Lennart E. Nilsson
Summary: This study investigated the occurrence and characteristics of carbapenem-resistant Enterobacteriaceae (CRE) in fecal samples from healthy individuals in 12 villages in Shandong Province, China. The results showed a rapid increase in CRE carriage from 2.4% to 13.4% from 2015 to 2017, with the majority of isolates being Escherichia coli carrying NDM-type carbapenemases. The worsening epidemiological situation highlights the need for further monitoring and interventions in the region.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Engineering, Multidisciplinary
Yingbo Shen, Fupin Hu, Yongqiang Wang, Dandan Yin, Lu Yang, Yiqiang Chen, Chunyan Xu, Jiyun Li, Junyao Jiang, Xueyang Wang, Yulin Fu, Dongyan Shao, Dejun Liu, Tengfei Ma, Chang Cai, Zhangqi Shen, Shaolin Wang, Juan Li, Rong Zhang, Yuebin Ke, Congming Wu, Jianzhong Shen, Timothy R. Walsh, Yang Wang
Summary: Although carbapenem use is prohibited in animals in China, carbapenem-resistant Escherichia coli (CREC), especially New Delhi metallo-b-lactamase (NDM)-producing strains, are widely prevalent in food-producing animals. A study found that being male, an age below 1, an age between 13 and 18, provinces with greater chicken production, and provinces with higher pig production were associated with higher odds of CREC infection. The study also revealed frequent transmission of CREC between humans and animals.
Article
Public, Environmental & Occupational Health
Xiaofan Zhang, Lei Peng, Yefang Ke, Dongdong Zhao, Guoqing Yu, Ying Zhou, Xi Li, Xingbei Weng
Summary: This study reports the coexistence of mcr1.1 and blaNDM-13 in a clinical E. coli isolate, and investigates the characteristics of the plasmids carrying these genes. The plasmids showed high similarity to related plasmids, and one of them was capable of trans conjugation and stable inheritance. This research expands the diversity of plasmids carrying blaNDM-13, which play a significant role in bacterial resistance.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Mengistu Hailemariam, Tsegaye Alemayehu, Bereket Tadesse, Netsanete Nigussie, Asnakech Agegnehu, Techilo Habtemariam, Mulubrhan Ali, Enkosilassie Mitiku, Elshaday Azerefegne
Summary: This study conducted a retrospective analysis of microbiological findings at Hawassa public hospital, revealing a bacterial infection prevalence of 32.6% and higher rates of bacterial bloodstream infection in children. Identified bacterial isolates were all multi-drug resistant, with Staphylococcus aureus having the highest proportion of multi-drug resistance.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Anja Mueller, Diana Seinige, Nils T. Grabowski, Birte Ahlfeld, Min Yue, Corinna Kehrenberg
Summary: Insects as novel foods are gaining popularity in Europe. While the presence of Shiga toxin-producing E. coli (STEC) in edible insects poses a potential health hazard, the majority of isolates belong to phylogenetic group A, mainly commensal E. coli. Moreover, the low resistance rate among the isolates indicates a low risk for the transmission of antimicrobial-resistant E. coli to consumers.
Article
Cell Biology
Jiangang Ma, Biao Tang, Jiahui Lin, Abdelaziz Ed-Dra, Hui Lin, Jing Wu, Yuzhi Dong, Hua Yang, Min Yue
Summary: Antimicrobial-resistant (AMR) pathogens pose a significant threat to global public health. The primary carriers of AMR genes, particularly against last-resort antibiotics, in Chinese hospitals have not been thoroughly studied. A study conducted in a sentinel hospital in China collected 157 E. coli strains from patients between January and July 2021. The study identified one bla(NDM-1)-positive, nine bla(NDM-5)-positive, and one mcr-1-positive E. coli strains resistant to meropenem and colistin in hospitalized patients. The study also found various virulence genes and different ST types associated with bla(NDM) and mcr-1 genes. The presence of mcr-1-positive E. coli in a one-day-old child closely related to strains with animal origins is noteworthy. Active monitoring systems at the genome level are necessary to surveil the spread of virulence and AMR genes in hospitals.
Article
Infectious Diseases
Suruchi Nepal, Sandra Maass, Stefano Grasso, Francis M. Cavallo, Juergen Bartel, Doerte Becher, Erik Bathoorn, Jan Maarten van Dijl
Summary: This study investigated the responses of a highly carbapenem-resistant Enterobacter roggenkampii bacterium to the carbapenem imipenem, revealing that the bacteria reduce metabolic activity to save resources for cell wall biogenesis and limit the formation of harmful reactive oxygen species. These findings provide insights into the adaptive responses of resistant bacteria to last-resort antibiotics, offering a glimpse into the future development of antibiotic resistance in this emerging group of pathogens.
Article
Medicine, General & Internal
Ji-Na Gu, Lin Chen, Xing-Bei Weng, Xiao-Yan Yang, Dan-Mei Pan
Summary: The research revealed that Escherichia coli Huamei202001 belongs to sequence type 410 and carries a blaNDM-5-encoding IncX3-type plasmid responsible for carbapenem resistance spreading. Only the patient was detected as having a positive faecal sample screening test for CRE.
FRONTIERS IN MEDICINE
(2021)
