Article
Medicine, General & Internal
Monica Romero Nieto, Sara Maestre Verdu, Vicente Gil, Carlos Perez Barba, Jose Antonio Quesada Rico, Reyes Pascual Perez
Summary: This study identified male sex, smoking, hypertension, urinary incontinence, and recurrent urinary tract infections as independent factors associated with the presence of ESBL-producing E. coli in patients with acute community-acquired pyelonephritis. The multivariate logistic models could correctly classify individuals with ESBL-producing E. coli infection in 80.2% of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Antonio Mandujano, Diana Veronica Cortes-Espinosa, Jose Vasquez-Villanueva, Paulina Guel, Gildardo Rivera, Karina Juarez-Rendon, Wendy Lizeth Cruz-Pulido, Guadalupe Aguilera-Arreola, Abraham Guerrero, Virgilio Bocanegra-Garcia, Ana Veronica Martinez-Vazquez
Summary: This study investigated the antimicrobial resistance profile of ESBL-producing E. coli among food-producing animals in Tamaulipas, Mexico. A total of 200 fecal samples were collected and 5.0% of the strains were confirmed as ESBL producers. High percentage of antimicrobial resistance was observed against gentamicin, tetracycline, and streptomycin. The study suggests that food-producing animals may serve as reservoirs and contribute to the spread of ESBL-producing bacteria.
Article
Microbiology
Zhiyuan He, Yulin Ma, Sirui Yang, Shuyuan Zhang, Shuai Liu, Jianxin Xiao, Yajing Wang, Wei Wang, Hongjian Yang, Shengli Li, Zhijun Cao
Summary: This study provides evidence that UDCA can confer diarrhea resistance in newborn dairy calves infected with ESBL-EAEC. UDCA blocks bacterial growth and invasion, alleviates commensal bacterial dysbiosis in neonatal mouse models of sepsis and colitis via the TGR5-NF-kappa B axis, and upregulates SCFA production in the hindgut digesta.
Article
Multidisciplinary Sciences
Hasan Ejaz, Sonia Younas, Khalid O. A. Abosalif, Kashaf Junaid, Badr Alzahrani, Abdullah Alsrhani, Abualgasim Elgaili Abdalla, Muhammad Ikram Ullah, Muhammad Usman Qamar, Sanaa S. M. Hamam
Summary: The colonization of ESBL-producing Enterobacteriaceae in animal gut microbiota poses a significant global threat, with a high prevalence of bla(CTX-M), bla(TEM), and bla(SHV) variants among enterobacteria. These genes, along with integrons, contribute to extensive drug resistance in human strains, highlighting the limited therapeutic options available.
Article
Infectious Diseases
Daniel Martak, Julia Guther, Tess D. Verschuuren, Benoit Valot, Nadine Conzelmann, Stefanie Bunk, M. Eugenia Riccio, Elena Salamanca, Alexandre Meunier, Charles P. Henriot, Caroline Pressacco Brossier, Xavier Bertrand, Ben S. Cooper, Stephan Harbarth, Evelina Tacconelli, Ad C. Fluit, Jesus Rodriguez-Bano, Jan A. J. W. Kluytmans, Silke Peter, Didier Hocquet
Summary: This study in five European cities found that food items were not the main source of ESBL-Ec and ESBL-Kp, as the strains from contaminated environments were genetically distinct from those in food. The findings suggest that human-to-human transmission is possibly the most frequent route of ESBL-Ec and ESBL-Kp transmission in high-income countries.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Microbiology
Anna R. Holtmann, Diana Meemken, Anja Mueller, Diana Seinige, Kathrin Buettner, Klaus Failing, Corinna Kehrenberg
Summary: This study revealed the presence of ESBL-/AmpC-E. coli in wild boars, with a significant positive association with human population density. The E. coli isolates carried various β-lactamase genes and showed multiple drug resistances.
Article
Veterinary Sciences
Dennis J. Woerde, Krystle L. Reagan, Barbara A. Byrne, Bart C. Weimer, Steven E. Epstein, Cory Schlesener, Bihua C. Huang, Jane E. Sykes
Summary: This study examined ESBL-producing bacterial infections in dogs and cats presenting to a veterinary teaching hospital from 2011-2021. Escherichia coli was the most commonly identified bacterial species, with urinary tract infection being the most common clinical presentation. Multi-drug resistance was present in 90% of ESBL-producing bacterial infections. Based on susceptibility patterns, antimicrobials such as piperacillin-tazobactam, amikacin, and cefoxitin may be alternative antibiotics to the current recommended regimen. Whole genome sequencing of bacteria revealed bla(CTX-M-15) as the most common ESBL gene.
VETERINARY SCIENCES
(2023)
Article
Infectious Diseases
Steev Loyola, Fatima Concha-Velasco, Jimena Pino-Duenas, Nancy Vasquez-Luna, Paola Juarez, Carlos Llanos, Guillermo Salvatierra, Jesus Tamariz, Andres G. Lescano
Summary: This study investigated the antimicrobial resistance and dynamics of ESBL-producing UPEC isolates from UTI cases seen at a local hospital in Cusco, Peru. The results showed high levels of multidrug resistance in ESBL-producing UPEC isolates, with varying resistance patterns over time and differences based on gender and healthcare service.
Article
Infectious Diseases
Kamrul Islam, Fekade B. Sime, Michelle J. Bauer, Brian M. Forde, Steven C. Wallis, Patrick Harris, Saiyuri Naicker, Tahmina Shirin, Zakir H. Habib, Meerjady S. Flora, Jason A. Roberts
Summary: The standard dosing regimens of piperacillin/tazobactam (TZP) effectively suppressed both ESBL-producing and non-ESBL-producing Escherichia coli, preventing the emergence of resistance.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Microbiology
Soomin Lee, Jae-Uk An, Jae-Ho Guk, Hyokeun Song, Saehah Yi, Woo-Hyun Kim, Seongbeom Cho
Summary: The study revealed a high prevalence of ESBL/AmpC-producing Escherichia coli in South Korean swine farms, with the highest infection rate observed in the weaning stage. CTX-M was detected in all stages, while CMY was predominantly found in the growing and finishing stages. Swine ESBL/AmpC-EC shared clone types with human counterparts, indicating a potential risk to humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Kamrul Islam, Aaron J. Heffernan, Saiyuri Naicker, Andrew Henderson, Mohammed Abdul Hassen Chowdhury, Jason A. Roberts, Fekade B. Sime
Summary: The study revealed a high prevalence of ESBLs and MBLs among E. coli clinical isolates in South Asia, with bla(CTX-M-15) and bla(NDM-1) being the most prevalent variants. Comprehensive resistance surveillance is needed in South Asia to guide antibiotic prescribing.
FUTURE MICROBIOLOGY
(2021)
Article
Infectious Diseases
Se Ra Shin, Seong Mi Noh, Woo Kyung Jung, Sook Shin, Young Kyung Park, Dong Chan Moon, Suk-Kyung Lim, Yong Ho Park, Kun Taek Park
Summary: The study conducted in South Korea between 2017 and 2019 identified various ESC-resistant bacterial isolates in companion animals, with predominant species being E. coli, Klebsiella, and others. These isolates displayed diversity in sequence types and resistance genes.
Article
Public, Environmental & Occupational Health
Meret Isler, Ramona Wissmann, Marina Morach, Katrin Zurfluh, Roger Stephan, Magdalena Nuesch-Inderbinen
Summary: This study revealed the presence of pathogenic bacteria and antibiotic-resistant bacteria in animal feces at some animal petting zoos and farm fairs in Switzerland, particularly finding Shiga toxin-producing Escherichia coli and methicillin-resistant Staphylococcus aureus.
ZOONOSES AND PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Hyunsoo Kim, Young Ah Kim, Young Hee Seo, Hyukmin Lee, Kyungwon Lee
Summary: This study aimed to investigate the molecular epidemiology of extended-spectrum-beta-lactamase producing Escherichia coli (ESBL-EC) from poultry, the poultry farm environment, and workers in Korea. The study found that the isolation rates of ESBL-EC were not negligible in the poultry industry-related samples, sharing common ESBL types of human ESBL-EC isolates in Korea. Whole genome sequencing revealed numerous antimicrobial resistance genes and well-known antimicrobial gene-carrying plasmids in the ESBL-EC isolates.
Article
Infectious Diseases
Jerome Ambroise, Elmostafa Benaissa, Leonid Mwana Wa Bene Irenge, El Mehdi Belouad, Bertrand Bearzatto, Jean-Francois Durant, Jamal Badir, Mostafa Elouennass, Jean-Luc Gala
Summary: This study aimed to provide data on ESBL-producing E. coli isolates from patients with extraintestinal infections in Morocco. The results underscore the pre-eminence of ST131 as the major factor driving the expansion of ExPEC in the Rabat region.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Editorial Material
Critical Care Medicine
Solen Kerneis, Sandrine Valade, Paul-Louis Woerther
INTENSIVE CARE MEDICINE
(2020)
Article
Multidisciplinary Sciences
Cecile Angebault, Mathilde Payen, Paul-Louis Woerther, Christophe Rodriguez, Francoise Botterel
Article
Multidisciplinary Sciences
Clelia Coutzac, Jean-Mehdi Jouniaux, Angelo Paci, Julien Schmidt, Domenico Mallardo, Atmane Seck, Vahe Asvatourian, Lydie Cassard, Patrick Saulnier, Ludovic Lacroix, Paul-Louis Woerther, Aurore Vozy, Marie Naigeon, Laetitia Nebot-Bral, Melanie Desbois, Ester Simeone, Christine Mateus, Lisa Boselli, Jonathan Grivel, Emilie Soularue, Patricia Lepage, Franck Carbonnel, Paolo Antonio Ascierto, Caroline Robert, Nathalie Chaput
NATURE COMMUNICATIONS
(2020)
Letter
Dermatology
C. Charpentier, F. Kouby, C. Hua, E. Sbidian, M. Darty, R. Bosc, N. De Prost, C. Gomart, P. -L. Woerther, A. Tazi, J. -W. Decousser, O. Chosidow
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Critical Care Medicine
Roman Mounier, Natacha Kapandji, Guillaume Gricourt, David Lobo, Christophe Rodriguez, Stephanie Pons, Chakib Djediat, Paul-Louis Woerther, Vincent Mellano, Bouziane Ait-Mamar, Vanessa Demontant, Biba Nebbad, Yann Senova, Melissa Arnaud, Fabrice Cook, Gilles Dhonneur, David Lebeaux
Summary: The study found that despite the presence of bacterial colonization on ICPTs, it did not lead to cerebral infections. Mature biofilm was the main bacterial lifestyle observed on ICPTs.
NEUROCRITICAL CARE
(2021)
Article
Infectious Diseases
Paul-Louis Woerther, Camille d'Humieres, Xavier Lescure, Luc Dubreuil, Christophe Rodriguez, Francois Barbier, Vincent Fihman, Etienne Ruppe
Summary: The article discusses the use of antibiotics against anaerobic bacteria and reevaluates the concept of anti-anaerobic spectrum in light of developments in the microbiota field. By highlighting the diversity of anaerobic bacteria species and the lack of antibiotic susceptibility profiles for many anaerobic bacteria, the relevance of the anti-anaerobic spectrum is challenged from clinical and ecological perspectives.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Letter
Dermatology
J. Lavaud, S. Hussler, G. Gricourt, N. deProst, C. Rodriguez, S. Ingen-Housz-Oro, O. Chosidow, C. Bernigaud, P. L. Woerther
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Infectious Diseases
Tomas Urbina, Keyvan Razazi, Clement Ourghanlian, Paul-Louis Woerther, Olivier Chosidow, Raphael Lepeule, Nicolas de Prost
Summary: Necrotizing soft tissue infections (NSTIs) are rare and life-threatening bacterial infections characterized by extensive tissue necrosis. Treatment requires broad-spectrum antibiotics, rapid surgical debridement, and management of organ failures. Antibiotic therapy faces challenges such as broad-spectrum activity, toxin reduction, and optimal tissue diffusion.
Article
Medicine, General & Internal
Vincent Fihman, Helene Faury, Amina Moussafeur, Raphaelle Huguet, Adrien Galy, Sebastien Gallien, Pascal Lim, Raphael Lepeule, Paul-Louis Woerther
Summary: For the diagnosis of infectious endocarditis, extending the incubation time of blood culture bottles beyond five days is generally unnecessary, unless patients have risk factors for Cutibacterium acnes infection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Guilhem Royer, Zoya Dixit, Jacques Pedron, Gautier Pierrat, Vanessa Demontant, Beatrice Bercot, Christophe Rodriguez, Marie-Anne Barny, Herve Jacquier, Paul-Louis Woerther
Summary: This study compared the chromosomal beta-lactamase from Pectobacterium versatile, PEC-1, with the well-known and globally distributed TEM-1 in terms of their genetic and functional properties. Although there are similarities between these enzymes, there is no definitive proof of gene transfer for the emergence of bla(PEC-1) from bla(TEM-1). The study suggests that P. versatile is the main reservoir of PEC-1, but it may also transfer to closely related species.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Keyvan Razazi, Flora Delamaire, Vincent Fihman, Mohamed Ahmed Boujelben, Nicolas Mongardon, Segolene Gendreau, Quentin de Roux, Nicolas de Prost, Guillaume Carteaux, Paul-Louis Woerther, Armand Mekontso Dessap
Summary: This study evaluated the application of a new rapid PCR method in mechanically ventilated patients. The results showed that this method had high sensitivity and specificity in diagnosing lung infections, and it could effectively guide antibiotic therapy. However, further research is needed to assess the potential of this method in antibiotic stewardship.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Pascal Lim, Margaux Le Maistre, Lucas Benoudiba Campanini, Quentin De Roux, Nicolas Mongardon, Valentin Landon, Hassina Bouguerra, David Aouate, Paul-Louis Woerther, Fihman Vincent, Adrien Galy, Vania Tacher, Sebastien Galien, Pierre-Vladimir Ennezat, Antonio Fiore, Thierry Folliguet, Raphaelle Huguet, Armand Mekontso-Dessap, Bernard Iung, Raphael Lepeule
Summary: Post-operative vasoplegic syndrome is a frequent and potentially fatal complication in cardiac surgery for infective endocarditis. The mechanism of vasoplegic syndrome appears to be more related to inflammatory cardiovascular injury rather than ongoing bacteremia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Dermatology
Margaux Mongereau, Camille Hua, Tomas Urbina, Paul Louis Woerther, Tiphaine Pelegrin, Nicola de'Angelis, Quentin De Roux, Romain Bosc, Barbara Hersant, Nicolas de Prost, Olivier Chosidow
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Romain Salle, Olivier Chosidow, Vincent Fihman, Nicolas de Prost, Narimane Zeghbib, Paul-Louis Woerther, Camille Hua
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Microbiology
Scott A. Cunningham, Christophe Rodriguez, Paul-Louis Woerther, Christophe Menigaux, Thomas Bauer, Jean-Louis Herrmann, Martin Rottman, Anne-Laure Roux, Jean-Louis Gaillard, Robin Patel, Faten El Sayed
Summary: In this study, we report the first emergence of dual resistance to levofloxacin and rifampin in C. avidum in vivo, in a patient who received both antibiotics orally during salvage debridement and implant retention of an ODRI. This study highlights potential limitations of the combination of oral rifampin and levofloxacin in patients undergoing these surgical procedures and the potential need to evaluate specific optimal therapy for emerging ODRI pathogens.
MICROBIOLOGY SPECTRUM
(2023)