Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

Poly(I:C)-Induced Protection of Neonatal Mice Against Intestinal Cryptosporidium parvum Infection Requires an Additional TLR5 Signal Provided by the Gut Flora

(2013) Louis Lantier et al.   JOURNAL OF INFECTIOUS DISEASES

A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis

(2013) Alejandro Castellanos-Gonzalez et al.   JOURNAL OF INFECTIOUS DISEASES

Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

(2013) Suresh Kumar Gorla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

(2013) Karen L Kotloff et al.   LANCET

Parasitic infections: Time to tackle cryptosporidiosis

(2013) Boris Striepen   NATURE

“Barriers" to Child Development and Human Potential: The Case for Including the “Neglected Enteric Protozoa" (NEP) and Other Enteropathy-Associated Pathogens in the NTDs

(2013) Luther A. Bartelt et al.   PLoS Neglected Tropical Diseases

An evaluation of the potential use ofCryptosporidiumspecies as agents for deliberate release: Table 1

(2013) Ralf Matthias Hagen et al.   Journal of the Royal Army Medical Corps

Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

(2012) Sivapriya Kirubakaran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum

(2012) Corey R. Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Burden of disease from cryptosporidiosis

(2012) Debbie-Ann T. Shirley et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Selective and Potent Urea Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

(2012) Suresh Kumar Gorla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of the Chinese medicine matrine on experimental C. parvum infection in BALB/c mice and MDBK cells

(2012) Fu Chen et al.   PARASITOLOGY RESEARCH

Microbes and microbial effector molecules in treatment of inflammatory disorders

(2011) Denise Kelly et al.   IMMUNOLOGICAL REVIEWS

Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP)

(2011) J. M. Fritzler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

The reductase domain in a Type I fatty acid synthase from the apicomplexan Cryptosporidium parvum: Restricted substrate preference towards very long chain fatty acyl thioesters

(2010) Guan Zhu et al.   BMC BIOCHEMISTRY

Structural Determinants of Inhibitor Selectivity in Prokaryotic IMP Dehydrogenases

(2010) Deviprasad R. Gollapalli et al.   CHEMISTRY & BIOLOGY

Treatment of cryptosporidiosis: do we know what we think we know?

(2010) Miguel M Cabada et al.   CURRENT OPINION IN INFECTIOUS DISEASES

UniFrac: an effective distance metric for microbial community comparison

(2010) Catherine Lozupone et al.   ISME Journal

Prodrug Activation byCryptosporidiumThymidine Kinase

(2010) Xin E. Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

(2010) Iain S. MacPherson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

The apicomplexanCryptosporidium parvumpossesses a single mitochondrial-type ferredoxin and ferredoxin:NADP+reductase system

(2010) Cheng Lei et al.   PROTEIN SCIENCE

Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii

(2010) Ryan C. Murphy et al.   ACS Medicinal Chemistry Letters

A Screening Pipeline for Antiparasitic Agents Targeting Cryptosporidium Inosine Monophosphate Dehydrogenase

(2010) Lisa Sharling et al.   PLoS Neglected Tropical Diseases

PyNAST: a flexible tool for aligning sequences to a template alignment

(2009) J. G. Caporaso et al.   BIOINFORMATICS

Minireview: Clinical cryptosporidiosis

(2009) Rachel M. Chalmers et al.   EXPERIMENTAL PARASITOLOGY

Triazole Inhibitors ofCryptosporidium parvumInosine 5′-Monophosphate Dehydrogenase

(2009) Sushil K. Maurya et al.   JOURNAL OF MEDICINAL CHEMISTRY

FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix

(2009) M. N. Price et al.   MOLECULAR BIOLOGY AND EVOLUTION

Efficacy of Pyrvinium Pamoate against Cryptosporidium parvum Infection In Vitro and in a Neonatal Mouse Model

(2008) A. S. Downey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis

(2008) Nwakaso N. Umejiego et al.   CHEMISTRY & BIOLOGY

Targeting a Uniquely Nonspecific Prenyl Synthase with Bisphosphonates to Combat Cryptosporidiosis

(2008) Jennifer D. Artz et al.   CHEMISTRY & BIOLOGY