期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 1, 页码 183-188出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01384-12
关键词
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资金
- INSERM [U914]
- UMR Universite Paris-Sud, France
- European Community [FP7/HEALTH-F3-2011-282512, FP7/HEALTH-F3-2001-278232, FP7/HEALTH-2009-241742]
- Kuwait University Research Administration grant [YM01/08]
Acinetobacter baumannii is an opportunistic pathogen that is an important source of nosocomial infections. Production of extended-spectrum beta-lactamases (ESBLs) of the GES type in A. baumannii has been increasingly reported, and some of these GES-type enzymes possess some carbapenemase activity. Our aim was to analyze the resistance determinants and the clonal relationships of carbapenem-nonsusceptible A. baumannii clinical isolates recovered from hospitals in Kuwait. A total of 63 isolates were analyzed, and all were found to be positive for blaGES-type genes. One isolate harbored the bla(GES-14) gene encoding an ESBL with significant carbapenemase activity, whereas the other isolates harbored the bla(GES-11) ESBL gene. Thirty-three isolates coharbored the bla(OXA-23) and bla(GES-11) genes. Analyses of the genetic locations indicated that the bla(GES-11/-14) genes were plasmid located. It is noteworthy that the bla(OXA-23) and bla(GES-11) genes were colocated onto a single plasmid. Nine different pulsotypes were observed among the 63 isolates. This study showed the emergence of GES-type ESBLs in A. baumannii in Kuwait, further suggesting that the Middle East region might be a reservoir for carbapenemase-producing A. baumannii.
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