Article
Cell Biology
Zhimin Bai, Min Chen, Qiaofa Lin, Ying Ye, Hongmei Fan, Kaizhen Wen, Jianxing Zeng, Donghong Huang, Wenfei Mo, Ying Lei, Zhijun Liao
Summary: By extracting feature vectors from protein sequences and using classification tools, MRSA and MSSA were successfully distinguished. MRSA showed high resistance to penicillin and high pathogenic risk. Cross-infection between different types of MRSA was found in Quanzhou, and MRSA in traditional hospitals exhibited increasingly blurred molecular characteristics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Martina Florianova, Kristyna Korena, Helena Juricova
Summary: This study evaluated the prevalence of Staphylococcus aureus in dry-fermented salami and found multidrug-resistant and virulent strains. The source of contamination was identified as raw pork and human carriers. Therefore, maintaining high standards of hygiene and manufacturing practices in food processing is crucial.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Immunology
Philip Nikolic, Poonam Mudgil, David G. Harman, John Whitehall
Summary: This study aimed to identify and compare the general differences in protein profiles among clinical strains of S. aureus sensitive and resistant to methicillin. The proteomic analysis revealed differences in protein abundances related to virulence, metabolism, and protein synthesis between MSSA and MRSA strains.
MICROBIAL PATHOGENESIS
(2023)
Review
Microbiology
Jhih-Hang Jiang, David R. Cameron, Cara Nethercott, Marta Aires-de-Sousa, Anton Y. Peleg
Summary: This review focuses on the mechanisms that trigger the establishment and maintenance of current, dominant MRSA lineages across the globe. Factors that influence MRSA's ability to colonize and cause disease within a host are discussed, with an emphasis on colonization and niche adaptation. Understanding these mechanisms may lead to the development of targeted therapies.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Biotechnology & Applied Microbiology
Santosh Paudel, Kamal Bagale, Swapnil Patel, Nicholas J. Kooyers, Ritwij Kulkarni
Summary: Human urine significantly alters the physiology and gene expression of MRSA, aiding the bacterium in adapting to the nutrient-limiting and immunologically hostile conditions within the urinary tract to facilitate UTI.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Hongbin Chen, Yuyao Yin, Lucy van Dorp, Liam P. Shaw, Hua Gao, Mislav Acman, Jizhen Yuan, Fengning Chen, Shijun Sun, Xiaojuan Wang, Shuguang Li, Yawei Zhang, Rhys A. Farrer, Hui Wang, Francois Balloux
Summary: The study reveals that in China, the community-associated MRSA strain ST59 is gradually replacing the healthcare-associated strain ST239, mainly due to its higher virulence potential rather than antibiotic resistance or biofilm production. The chemotaxis inhibitory protein (chp) carried by ST59 may be a significant factor contributing to its increased virulence.
Article
Immunology
Xinyi Wang, Huilin Zhao, Bingjie Wang, Ying Zhou, Yanlei Xu, Lulin Rao, Wenxiu Ai, Yinjuan Guo, Xiaocui Wu, Jingyi Yu, Longhua Hu, Lizhong Han, Shuying Chen, Liang Chen, Fangyou Yu
Summary: This study characterized six ST8 strains collected from three tertiary hospitals in China, and found that two MRSA strains exhibited similar virulence potential as the epidemic USA300 strain. These findings highlight the need for enhanced surveillance of these highly virulent MRSA strains in China.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Grace Kaul, Abdul Akhir, Manjulika Shukla, Kundan S. Rawat, Chandra P. Sharma, Komal G. Sangu, Haridas B. Rode, Atul Goel, Sidharth Chopra
Summary: Nitazoxanide exhibits potent activity against clinical drug-resistant S. aureus and Enterococcus spp., concentration-dependent killing, ability to eradicate S. aureus biofilm, and lack of generation of resistance in S. aureus. Nitazoxanide synergizes strongly with linezolid against linezolid-susceptible and -resistant S. aureus, showing superior activity compared to untreated control and drug-alone treatment groups, both in vitro and in vivo.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Samantha D. Yeager, Justin E. Oliver, Mahmoud A. Shorman, Laurence R. Wright, Michael P. Veve
Summary: This study compared the effectiveness and safety of oral step-down linezolid with standard parenteral therapy in MRSA bloodstream infection. The results showed that linezolid had similar clinical outcomes and safety profiles compared to parenteral therapy, with fewer adverse events requiring re-hospitalization. Additional research is needed to explore the use of step-down linezolid in MRSA bloodstream infection.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Microbiology
Huilin Zhao, Xiaocui Wu, Bingjie Wang, Li Shen, Lulin Rao, Xinyi Wang, Jiao Zhang, Yanghua Xiao, Yanlei Xu, Jingyi Yu, Yinjuan Guo, Ying Zhou, Baoshan Wan, Chunyang Wu, Liang Chen, Fangyou Yu
Summary: By reconstructing the phylogeny of ST22 MRSA strains from China and global sources, it was found that global ST22 strains can be divided into three clades (I, II, and III). China ST22 strains were primarily found in clade II (IIb and IIc) and also in clade III, indicating different origins of China ST22-MRSA clones. Subclade IIc (SCCmecIVa-t309) strains exhibited particularly strong lethality and invasiveness compared to other dominant MRSA strains. This study highlights the emergence of a highly virulent ST22 MRSA subclade in China.
Article
Microbiology
Nidhi Satishkumar, Li-Yin Lai, Nagaraja Mukkayyan, Bruce E. Vogel, Som S. Chatterjee
Summary: This study demonstrates that PBP4 is an important mediator of beta-lactam resistance not only in methicillin-susceptible Staphylococcus aureus (MSSA) strains but also in MRSA strains. When present together, overexpression of PBP2a and PBP4 can lead to increased beta-lactam resistance, causing treatment complications. Monitoring PBP4-associated resistance in clinical settings and understanding the mechanistic basis of this resistance are important for developing targeted treatments. Additionally, strains with increased PBP4 expression are less pathogenic, indicating a potential trade-off between beta-lactam resistance and virulence.
MICROBIOLOGY SPECTRUM
(2022)
Article
Veterinary Sciences
Hester Rynhoud, Brian M. Forde, Scott A. Beatson, Sam Abraham, Erika Meler, Ricardo J. Soares Magalhaes, Justine S. Gibson
Summary: This study investigated the molecular epidemiology of MRSA and MRSP isolates in dogs and cats, revealing significant differences in resistance and virulence factors between different sequence types. However, there were no differences in individual and clinical factors between predominant sequence types. The majority of isolates showed high levels of antimicrobial resistance, posing a potential threat to human and veterinary health. The phylogenetic clustering of isolates suggests potential importation of clones from countries with high volume of pet movements, warranting further investigation.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Mengli Jin, Shuyue Zhu, Yating Tang, Xiangri Kong, Xingye Wang, Yufen Li, Shuang Jiang, Lin Wei, Chunjie Hu, Bingmei Wang, Wu Song
Summary: Antimicrobial resistance (AMR) is a global health threat, and there is a need for new anti-infective agents. Ayanin, a flavonoid extracted from Callicarpa nudiflora, was found to be an inhibitor of MRSA ClpP, suggesting its potential therapeutic effect against MRSA infections.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Microbiology
Le Chen, Zihui Wang, Tao Xu, Hongfei Ge, Fangyue Zhou, Xiaoyi Zhu, Xianhui Li, Di Qu, Chunquan Zheng, Yang Wu, Keqing Zhao
Summary: The two-component signal transduction system graRS plays a crucial role in regulating the antibiotic resistance and virulence of MRSA, with the genes mainly involved in metabolic processes and pathogenesis, as well as being associated with the virulence and infection of S. aureus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Hideo Kato, Mao Hagihara, Nobuhiro Asai, Yuichi Shibata, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
Summary: This study found through a meta-analysis of RCTs and CSs that LZD has significantly higher clinical cure and microbiological eradication rates compared to VCM in the treatment of proven MRSA pneumonia. However, there was no significant difference in mortality and adverse events between VCM and LZD.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)