期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 5, 页码 2424-2427出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01795-10
关键词
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资金
- INSERM [U914]
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
- Universite Paris XI, France
- European Community (TROCAR) [HEALTH-F3-2008-223031]
- European Community (TEMPOtest-QC) [HEALTH-2009-241742]
Acinetobacter baumannii isolate AP2 was recovered from a bronchial lavage sample of a patient hospitalized in Paris, France. A. baumannii AP2 was resistant to all beta-lactams, including carbapenems, and expressed the extended-spectrum beta-lactamase (ESBL) PER-7, which differs from PER-1 by 4 amino acid substitutions. Compared to PER-1, PER-7 possessed higher-level hydrolytic activities against cephalosporins and aztreonam. The bla(PER-7) gene was chromosomally located and associated with a mosaic class 1 integron structure. Additionally, isolate AP2 expressed the carbapenem-hydrolyzing oxacillinase OXA-23 and the 16S RNA methylase ArmA, conferring high-level resistance to aminoglycosides.
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