Article
Engineering, Biomedical
Ming-Chen Sun, Ying-Fang Chen, Di Liu, Xiao-Ling Xu, Yu-Chan You, Wei Lu, Yun-Juan Shi, Ming-Yang Ren, Yi-Bin Fan, Yong-Zhong Du, Xiao-Hua Tao
Summary: The widespread use of mupirocin for treating MRSA infections has led to the emergence of mupirocin-resistant Staphylococcus aureus (MuRSA), posing a serious medical threat. In order to combat MuRSA, researchers have developed a modified mupirocin and silver complex (TPGS/Mup-Ag) to enhance its antibacterial activity. The results showed that TPGS/Mup-Ag can effectively eliminate bacterial infection and accelerate wound healing in both in vitro and in vivo experiments.
MATERIALS TODAY BIO
(2023)
Review
Infectious Diseases
Matthew S. Linz, Arun Mattappallil, Diana Finkel, Dane Parker
Summary: The most common pathogen in skin-and-soft-tissue infections (SSTIs) in the United States is the pathogenic bacterium Staphylococcus aureus. The epidemic clone USA300 is responsible for the majority of S. aureus SSTIs in the USA. These infections can be serious, with a global age-standardized mortality rate of 0.5 in 2019. S. aureus SSTIs can present as superficial infections with local symptoms or as monomicrobial necrotizing fasciitis, which can cause systemic manifestations and potentially lead to complications or death. Treatment for S. aureus SSTIs usually involves oral therapy, with severe cases requiring parenteral therapy. Treatment options range from cephalosporins and penicillin agents such as oxacillin for methicillin-sensitive S. aureus (MSSA), to vancomycin for methicillin-resistant S. aureus (MRSA). Treatment challenges include adverse effects, risk for Clostridioides difficile infection, and antibiotic resistance.
Article
Immunology
Patrick G. Hogan, Katelyn L. Parrish, Ryan L. Mork, Mary G. Boyle, Carol E. Muenks, Ryley M. Thompson, John J. Morelli, Melanie L. Sullivan, David A. Hunstad, Juliane Bubeck Wardenburg, Andrey Rzhetsky, Sarah J. Gehlert, Carey-Ann D. Burnham, Stephanie A. Fritz
Summary: The study showed that targeting household members with prior year SSTI for decolonization was as effective in preventing SSTI as decolonizing all household members, demonstrating that a personalized approach is feasible.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Elke S. Bergmann-Leitner, Eugene V. Millar, Elizabeth H. Duncan, David R. Tribble, Patrick M. Carey, Michael W. Ellis, Katrin Mende, Jason W. Bennett, Sidhartha Chaudhury
Summary: This study demonstrates the power of immunoprofiling for identifying predictive factors of the pre-illness state of SSTI, thus identifying early stages of infection and individuals susceptible to SSTI.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Infectious Diseases
Florencia Mariani, Estela Maria Galvan
Summary: Polymicrobial biofilms create a complex environment where different microorganisms can interact in various ways and alter the outcome of diseases. This review article explores the microorganisms commonly found together with Staphylococcus aureus in skin and soft tissue infections, such as Pseudomonas aeruginosa, Escherichia coli, Enterococcus spp., Acinetobacter baumannii, and Candida albicans. The molecular mechanisms and impact of these polymicrobial interactions on pathogenesis and antimicrobial susceptibility are also discussed.
Article
Infectious Diseases
Sofia Santos Costa, Rute Ribeiro, Maria Serrano, Ketlyn Oliveira, Carolina Ferreira, Marta Leal, Constanca Pomba, Isabel Couto
Summary: This study investigated Staphylococcus aureus as a cause of skin and soft tissue infections in animals. It found a high frequency of MRSA strains and highlighted the circulation of clonal lineages between companion animals and humans.
Article
Infectious Diseases
Carolina Ferreira, Sofia Santos Costa, Maria Serrano, Ketlyn Oliveira, Graca Trigueiro, Constanca Pomba, Isabel Couto
Summary: This study analyzed a collection of 34 S. aureus isolates from ambulatory patients in Portugal, and found that nearly half of the isolates were MRSA and/or MDR. The isolates showed high antimicrobial resistance and genetic diversity, with prevalence of clonal lineages CC5, CC22, and CC8, and PVL-encoding genes were found in 20.6% of the isolates.
Article
Integrative & Complementary Medicine
P. A. Akinduti, V Emoh-Robinson, H. F. Obamoh-Triumphant, Y. D. Obafemi, T. T. Banjo
Summary: The antibacterial activities of aqueous extracts from Azadirachta indica and Moringa oleifera were found to be effective against multidrug resistance Staphylococcus aureus associated with skin and soft tissue infections. Other extracts also showed some inhibitory effects.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Microbiology
Xiao-chao Duan, Xin-xin Li, Xiang-min Li, Shuang Wang, Fen-qiang Zhang, Ping Qian
Summary: In this study, a novel chimeric lysin ClyQ was constructed, which showed a broad host range and could synergize with mupirocin to treat S. aureus skin infections. The combination of ClyQ and mupirocin also delayed the development of S. aureus resistance to mupirocin.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Venanzio Vella, Ilaria Galgani, Letizia Polito, Ashwani Kumar Arora, C. Buddy Creech, Michael Z. David, Franklin D. Lowy, Nenad Macesic, Jessica P. Ridgway, Anne-Catrin Uhlemann, Fabio Bagnoli
Summary: The study found that Staphylococcus aureus skin and soft tissue infections are common among healthy adults, with recurrence occurring in at least 1 in 6 individuals within 1 year after the primary event. Most patients experience their first recurrence within the first three months following the primary infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Yinjuan Guo, Linling Xu, Bingjie Wang, Lulin Rao, Yanlei Xu, Xinyi Wang, Huilin Zhao, Jingyi Yu, Ying Zhou, Fangyou Yu
Summary: Mupirocin is an important antimicrobial agent in the eradication of MRSA colonization. Mupirocin-resistant MR-MRSA isolates with different molecular characteristics were analyzed, and it was found that they carried different SCCmec types, spa types, and virulence genes. Most of the MR-MRSA isolates were also resistant to other antibiotics, especially erythromycin and clindamycin. The study identified a novel high-level mupirocin-resistant MR-MRSA strain, which poses a therapeutic challenge for MRSA infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Chun Yi Lee, Yu Ping Fang, Tsung Hua Wu, Yu Feng Chang, Chia Hsing Sung
Summary: This study investigated the molecular characteristics of MRSA strains in custodial facilities and a community hospital in Taiwan. The results showed that ST59, ST8, and ST45 MRSA were the predominant strains causing SSTIs. Furthermore, there was a high rate of mupirocin resistance gene and a relatively low frequency of chlorhexidine resistance gene.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Review
Infectious Diseases
Joya-Rita Hindy, Sara F. Haddad, Souha S. Kanj
Summary: This article reviews several new drugs for MRSA SSTI treatment and discusses their advantages and disadvantages. However, current IDSA guidelines for MRSA infection and SSTIs, as well as the recently published UK guidelines on MRSA treatment, only consider these drugs as alternative choices or do not mention them at all.
CURRENT OPINION IN INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Sofia Maraki, Viktoria Eirini Mavromanolaki, Dimitra Stafylaki, Evangelia Iliaki-Giannakoudaki, George Hamilos
Summary: Skin and soft tissue infections (SSTIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) are associated with significant morbidity and healthcare costs. Vancomycin is the preferred treatment for complicated SSTIs caused by MRSA, but newer antibiotics like ceftobiprole, dalbavancin, and tedizolid have shown promise. In this study, we evaluated the in vitro activity of these antibiotics against MRSA clinical isolates and found that dalbavancin had the lowest MIC90, followed by tedizolid, linezolid, ceftobiprole, and daptomycin. Tedizolid exhibited superior in vitro activity compared to other antibiotics. Multidrug-resistant phenotypes were detected in the majority of isolates. The findings suggest that ceftobiprole, dalbavancin, and tedizolid are effective antimicrobials for MRSA-related SSTIs.
Review
Infectious Diseases
Eliana M. Cela, Dolores Urquiza, Marisa I. Gomez, Cintia D. Gonzalez
Summary: This article discusses the challenges in the treatment of Staphylococcus aureus infections and proposes strategies to improve antibiotic sensitivity and efficacy. It also explores alternative non-antibiotic-based experimental therapies.
Article
Infectious Diseases
Jeffrey N. Johnston, Sheldon L. Kaplan, Edward O. Mason, Kristina G. Hulten
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2015)
Article
Public, Environmental & Occupational Health
Judith R. Campbell, Kristina Hulten, Carol J. Baker
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2011)
Article
Otorhinolaryngology
Crystal R. Whitby, Sheldon L. Kaplan, Edward O. Mason, Maria Carrillo-Marquez, Linda B. Lamberth, Wendy A. Hammerman, Kristina G. Hulten
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2011)
Article
Orthopedics
Mohan V. Belthur, Sherri B. Birchansky, Alejandro A. Verdugo, Edward O. Mason, Kristina G. Hulten, Sheldon L. Kaplan, E. O'Brian Smith, William A. Phillips, Jacob Weinberg
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2012)
Article
Microbiology
Morgan C. Green, Edward O. Mason, Sheldon L. Kaplan, Linda B. Lamberth, Stephanie H. Stovall, Laurence B. Givner, John S. Bradley, Tina Q. Tan, William J. Barson, Jill A. Hoffman, Philana Ling Lin, Kristina G. Hulten
JOURNAL OF CLINICAL MICROBIOLOGY
(2011)
Article
Microbiology
Jessica Ing, Edward O. Mason, Sheldon L. Kaplan, Linda B. Lamberth, Paula A. Revell, Ruth Ann Luna, Kristina G. Hulten
JOURNAL OF CLINICAL MICROBIOLOGY
(2012)
Article
Microbiology
Kristina G. Hulten, Sheldon L. Kaplan, Linda B. Lamberth, William J. Barson, Jose R. Romero, Philana Ling Lin, John S. Bradley, Laurence B. Givner, Tina Q. Tan, Jill A. Hoffman, Edward O. Mason
JOURNAL OF CLINICAL MICROBIOLOGY
(2013)
Article
Infectious Diseases
Erin N. Menne, Rona Yoffe Sonabend, Edward O. Mason, Linda B. Lamberth, Wendy A. Hammerman, Charles G. Minard, Sheldon L. Kaplan, Kristina G. Hulten
JOURNAL OF INFECTION
(2012)
Article
Medicine, General & Internal
Marcela Campo, Ray Hachem, Ying Jiang, Tanya Dvorak, Maria Carrillo-Marquez, Kristina Hulten, Roy F. Chemaly, Issam Raad
Article
Immunology
Regine M. Fortunov, Kristina G. Hulten, Coburn H. Allen, Wendy A. Hammerman, Linda B. Lamberth, Edward O. Mason, Sheldon L. Kaplan
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2011)
Article
Immunology
J. Chase McNeil, Kristina G. Hulten, Sheldon L. Kaplan, Heidi L. Schwarzwald, Edward O. Mason
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2012)
Article
Immunology
Claire E. Bocchini, Edward O. Mason, Kristina G. Hulten, Wendy A. Hammerman, Sheldon L. Kaplan
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2013)
Article
Immunology
J. Chase McNeil, Kristina G. Hulten, Sheldon L. Kaplan, Donald H. Mahoney, Edward O. Mason
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2013)
Article
Immunology
Cecilia Torres Day, Sheldon L. Kaplan, Edward O. Mason, Kristina G. Hulten
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2014)
Article
Gastroenterology & Hepatology
Faith D. Ihekweazu, Tatiana Y. Fofanova, Karen Queliza, Dorottya Nagy-Szakal, Christopher J. Stewart, Melinda A. Engevik, Kristina G. Hulten, Nina Tatevian, David Y. Graham, James Versalovic, Joseph F. Petrosino, Richard Kellermayer
