Article
Immunology
Dariusz A. Hareza, Sara E. Cosgrove, Patricia J. Simner, Anthony D. Harris, Yehudit Bergman, Rick Conzemius, Emily Jacobs, Stephan Beisken, Pranita D. Tamma
Summary: This study investigated the clinical outcomes and optimal treatment methods for patients with ESBL-E bloodstream infections that do not produce CTX-M. The findings suggest that non-CTX-M and CTX-M ESBL-E infections are equally concerning and associated with similar clinical outcomes. Meropenem may be associated with improved survival in patients with non-CTX-M ESBL-E infections, highlighting the potential benefit of comprehensive molecular diagnostics for early antibiotic optimization in ESBL-E infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Se Ra Shin, Seong Mi Noh, Woo Kyung Jung, Sook Shin, Young Kyung Park, Dong Chan Moon, Suk-Kyung Lim, Yong Ho Park, Kun Taek Park
Summary: The study conducted in South Korea between 2017 and 2019 identified various ESC-resistant bacterial isolates in companion animals, with predominant species being E. coli, Klebsiella, and others. These isolates displayed diversity in sequence types and resistance genes.
Article
Microbiology
Sun Hee Moon, En Huang
Summary: Understanding cefiderocol resistance mechanisms is crucial for developing solutions against infections and resistance development. Cefiderocol resistance in Klebsiella pneumoniae AR 0047 is associated with SHV beta-lactamase activities and loss of the outer membrane porin. The combination of cefiderocol and avibactam presents an opportunity to enhance effectiveness against cefiderocol-resistant pathogens.
MICROBIOLOGY SPECTRUM
(2023)
Review
Infectious Diseases
Huan Zhang, Beibei Liang, Jin Wang, Yun Cai
Summary: This study compared the efficacy of non-carbapenem beta-lactam/beta-lactamase inhibitors (BLBLIs) with carbapenems for the treatment of UTIs caused by ESBL-PE. The results showed no significant difference in clinical success and mortality between the two treatment groups, but a slightly higher rate of microbiological success was observed in the BLBLIs group.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Microbiology
Alireza Barani, Akram Sadat Tabatabaee Bafroee, Leila Jabalameli
Summary: This study in Ahvaz, Iran found a high prevalence of ESBL genes among intestinal E. coli isolates from drug users, with bla-TEM gene being the most prevalent. The multidrug resistance (MDR) patterns, especially simultaneous resistance to seven antimicrobials, highlight the risk of transferring resistance genes between nonpathogenic and pathogenic bacteria.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Monica Romero Nieto, Sara Maestre Verdu, Vicente Gil, Carlos Perez Barba, Jose Antonio Quesada Rico, Reyes Pascual Perez
Summary: This study identified male sex, smoking, hypertension, urinary incontinence, and recurrent urinary tract infections as independent factors associated with the presence of ESBL-producing E. coli in patients with acute community-acquired pyelonephritis. The multivariate logistic models could correctly classify individuals with ESBL-producing E. coli infection in 80.2% of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Judith A. Anesi, Ebbing Lautenbach, Pranita D. Tamma, Kerri A. Thom, Emily A. Blumberg, Kevin Alby, Warren B. Bilker, Alissa Werzen, Pam Tolomeo, Jacqueline Omorogbe, Lisa Pineles, Jennifer H. Han
Summary: The study identified several risk factors for ESBL-EB BSIs among solid organ transplant recipients, including prior ESBL-EB colonization, corticosteroid-containing immunosuppression regimen, corticosteroid treatment for acute rejection, and exposure to certain antibiotics. Further studies and interventions are needed to explore and address these modifiable risk factors in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Nafeesa Yasmeen, Bilal Aslam, Liang-xing Fang, Zulqarnain Baloch, Yahong Liu
Summary: This study investigated the occurrence and dissemination of extended-spectrum beta-lactamase (ESBL) harboring Klebsiella pneumoniae in various ecological niches under the one health approach. A total of 793 samples from animals, humans, and the environment were collected. The findings revealed higher occurrence of ESBL genes in animals compared to humans and the environment, with 18 distinct sequence types (STs) and 12 clonal complexes of K. pneumoniae observed. The high occurrence rate of ESBL-harboring K. pneumoniae in animals is alarming and has the potential to be disseminated to the associated environment and community.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Analytical
Manal Suleiman, George Abu-Aqil, Uraib Sharaha, Klaris Riesenberg, Orli Sagi, Itshak Lapidot, Mahmoud Huleihel, Ahmad Salman
Summary: Rapid detection of ESBL+ bacteria is crucial for efficient treatment of bacterial infections. Results from the study demonstrate the possibility of accurately identifying ESBL+ Klebsiella pneumoniae within about 20 minutes, with approximately 89% accuracy, sensitivity, and specificity.
Article
Microbiology
Jin Ju Park, Eun-ju Jung, Jae-Young Kim, Yu Bin Seo, Jacob Lee, Younghee Jung
Summary: This study compared the 30-day mortality rates of patients receiving Ertapenem and other carbapenems for the treatment of ESBL-producing Enterobacterales bacteremia. The results showed that there was no difference in mortality rates between Ertapenem and other carbapenems, suggesting comparable efficacy. The study also found no difference in secondary outcomes such as Clostridioides diffide infection (CDI) and the emergence of multidrug-resistant Gram-negative bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Tushar Kumar Dey, Johanna Frida Lindahl, Ake Lundkvist, Delia Grace, Ram Pratim Deka, Rajeswari Shome, Samiran Bandyopadhyay, Naresh Kumar Goyal, Garima Sharma, Bibek Ranjan Shome
Summary: This study investigated the prevalence of beta-lactamase-producing Enterobacteriaceae in milk samples from two Indian states, revealing the presence of various prevalent beta-lactamase genes. The findings underscore the potential risk of antimicrobial-resistant bacteria in dairy products and the need for comprehensive approaches to accurately assess antibiotic resistance.
Article
Infectious Diseases
Maria E. Riccio, Tess Verschuuren, Nadine Conzelmann, Daniel Martak, Alexandre Meunier, Elena Salamanca, Mercedes Delgado, Julia Guther, Silke Peter, Julian Paganini, Romain Martischang, Julien Sauser, Marlieke E. A. de Kraker, Abdessalam Cherkaoui, Ad C. Fluit, Ben S. Cooper, Didier Hocquet, Jan A. J. W. Kluytmans, Evelina Tacconelli, Jesus Rodriguez-Bano, Stephan Harbarth
Summary: The study found that ESBL-PE positive index patients discharged from hospitals are significant sources of ESBL-PE transmission within households, particularly during the first two months after discharge. The household transmission rate of ESBL-Kp was higher than ESBL-Ec, although there were more acquisitions of ESBL-Ec. Assisting the index patient with urinary and fecal excretions increased the risk of ESBL-PE transmission.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Microbiology
Dagninet Alelign, Aschalew Kidanewold
Summary: The study identified a significant number of multidrug-resistant ES beta L and carbapenemase-producing Enterobacteriaceae in street foods, suggesting they may be a potential source of multidrug-resistant foodborne infections. Regular examinations of street food items and tracking medication resistance trends are essential.
Article
Microbiology
Tatsuya Ishikawa, Nayuta Furukawa, Emilia Caselli, Fabio Prati, Magdalena A. Taracila, Christopher R. Bethel, Yoshikazu Ishii, Akiko Shimizu-Ibuka, Robert A. Bonomo
Summary: The study identified a novel boronic acid transition state inhibitor S02030 that can effectively inhibit multidrug-resistant Gram-negative bacteria, providing a potential new direction for future treatments.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Kamrul Islam, Aaron J. Heffernan, Saiyuri Naicker, Andrew Henderson, Mohammed Abdul Hassen Chowdhury, Jason A. Roberts, Fekade B. Sime
Summary: The study revealed a high prevalence of ESBLs and MBLs among E. coli clinical isolates in South Asia, with bla(CTX-M-15) and bla(NDM-1) being the most prevalent variants. Comprehensive resistance surveillance is needed in South Asia to guide antibiotic prescribing.
FUTURE MICROBIOLOGY
(2021)