期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 55, 期 4, 页码 1784-1786出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01710-10
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资金
- United Kingdom Medical Research Council [G0600810]
- United Kingdom Biological and Biosciences Research Council
- Novacta Biosystems, Welwyn Garden City, Hertfordshire, United Kingdom
- Medical Research Council [G0600810] Funding Source: researchfish
- MRC [G0600810] Funding Source: UKRI
We further examined the usefulness of previously reported Bacillus subtilis biosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupirocin, indolmycin, and borrelidin, some inhibitors of peptidoglycan synthesis, and most membrane-damaging agents. However, the biosensors confirmed the modes of action of several RNA polymerase inhibitors and DNA intercalators and provided new insights into the possible modes of action of ciprofloxacin, anhydrotetracycline, corralopyronin, 8-hydroxyquinoline, and juglone.
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