Review
Medicine, General & Internal
Simona Mirel, Alexandra Pusta, Mihaela Moldovan, Septimiu Moldovan
Summary: Recent advances in biomaterials have improved surgical options, allowing for chemical control and tissue regeneration. Various biomaterials can be used for medical devices, but infection risk is an important consideration.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Polymer Science
Selma Benito-Martinez, Barbara Perez-Kohler, Marta Rodriguez, Francisca Garcia-Moreno, Veronica Gomez-Gil, Gemma Pascual, Juan Manuel Bellon
Summary: The study suggests that coating meshes with chlorhexidine or rifampicin-carboxymethylcellulose biopolymer gel may help improve abdominal wall tissue repair in the presence of infection following mesh implantation.
Review
Materials Science, Multidisciplinary
Wei He, Guangxiu Cao, Xueping Gan, Yubo Fan, Baoqing Pei, Xiaoming Li
Summary: Soft tissue substitutes undergo large deformations in vivo, and it is important to match the deformation behavior between substitute and tissue for effective repair. Evaluation methods for mechanical biocompatibility include physicomechanical testing, non-invasive measurement, and numerical modeling, each with its own advantages and limitations. A comprehensive summary of these methods is needed to guide the selection and improvement of evaluation methods for soft tissue substitutes.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Engineering, Biomedical
Ilmutdin M. Abdulagatov, Razin M. Ragimov, Magomed A. Khamidov, Abay M. Maksumova, Naida M. Abdullaeva
Summary: Thermal atomic layer deposition (ALD) was used to synthesize vanadium (V)-doped TiO2 thin nanofilm on polypropylene (PP) hernia meshes to improve antibacterial properties. The V-doped TiO2 coatings showed significant inhibition of S. aureus and E. coli adhesion and demonstrated excellent antibacterial activity.
BIOMEDICAL MATERIALS
(2022)
Article
Surgery
Alessandra Grillo, Zargham Hyder, Vivek Mudera, Alvena Kureshi
Summary: This study investigated the effects of ethylene oxide (EO) sterilization on the mechanical properties and biocompatibility of low-cost meshes (LCM). The results showed that EO sterilization affects the mechanical properties of LCM, but they still have values close to native tissues. The biocompatibility of LCM2 was not affected by EO sterilization, as human dermal fibroblasts (HDFs) attached and proliferated on the mesh.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biochemistry & Molecular Biology
Karolina Dydak, Adam Junka, Grzegorz Nowacki, Justyna Paleczny, Patrycja Szymczyk-Ziolkowska, Aleksandra Gorzynska, Olga Aniolek, Marzenna Bartoszewicz
Summary: This study evaluated the suitability of bacterial cellulose and gentamicin-modified mesh adjuvants in surgical meshes and found that the modified mesh had no cytotoxic effect and effectively inhibited bacterial growth compared to non-coated mesh, suggesting that the modified mesh can be used as an effective implant in hernia surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natasha Bokhari, Abida Yasmeen, Asif Ali, Hamad Khalid, Rong Wang, Mustehsan Bashir, Faiza Sharif
Summary: Meshes made from natural silk are knitted and coated with a blend polymer of chitosan and bacterial cellulose, using extracts from pomegranate peel, Nigella sativa seed, licorice root, and bearberry leaf. Characterization analysis shows the presence of bioactive chemicals in the extracts and the coated surface. The coated meshes have higher tensile strength, sustained release of phytochemical extracts, and promote wound/tissue healing and combat bacterial infections, making them suitable for hernia repair and fistula/cleft palate repair.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Applied
Huiwen Hu, Huanchao Sun, Zhiwen Jiang, Shuo Wang, Chenqi Liu, Mingyu Zou, Ruibao Ju, Zhilong Feng, Wanshun Liu, Ting Wang, Baoqin Han
Summary: This study synthesized hydroxypropyl chitosan azide and applied it as a hydrogel coating on a polypropylene mesh. The hydrogel exhibited excellent biocompatibility and biodegradability, and adhered well to the mesh. During the 180-day follow-up period, the coated mesh promoted wound healing by stimulating the secretion of transforming growth factor-beta1. The coated mesh also showed improved fibrin lysozyme activity and reduced intraperitoneal adhesion compared to the uncoated mesh.
CARBOHYDRATE POLYMERS
(2022)
Article
Surgery
Jordan A. Bilezikian, Paul L. Tenzel, Robert G. Johnson, William F. Powers, William W. Hope
Summary: This study compared two different lightweight polypropylene meshes for laparoscopic and robotic inguinal hernia repairs, finding that robotic mesh placement significantly increased insertion time. Self-assessment surveys showed no significant difference between the meshes in difficulty of placement. Based on the data, these meshes can be used interchangeably based on the surgeon's preference.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Engineering, Biomedical
Vittoria Civilini, Vincenzo Giacalone, Alberto L. Audenino, Mara Terzini
Summary: Despite the lack of specific standards, this study provides a rigorous test protocol for mechanical comparison of surgical meshes used in hernia repair and urogynecologic surgery. The protocol consists of three quasi-static test methods and post-processing procedures to compute mechanical parameters. The test protocol was successfully applied to various meshes and showed intra-subject variability with coefficient of variations around 0.05, demonstrating its repeatability.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
J. Jayakumar, V. A. Kumar, L. Biswas, R. Biswas
Summary: Staphylococcus aureus causes various infections and the development of effective anti-staphylococcal agents, such as lysostaphin, is crucial. However, issues with immunogenicity and bio-availability hinder its clinical application.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Chemistry, Physical
Shuang Yu, Wentao Shi, Shadi Houshyar, Xin Wang, Pibo Ma
Summary: This study successfully improved the biocompatibility of polypropylene mesh by using chitosan and sodium alginate as coatings, promoting cell attachment and proliferation.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Surgery
A. Grillo, Z. Hyder, V Mudera, A. Kureshi
Summary: The study assessed the mechanical and ultrastructural properties of two UK-sourced low-cost meshes (LCM) and their in vitro biocompatibility. Results showed that both LCMs had comparable biocompatibility and mechanical properties to commercial meshes.
Article
Public, Environmental & Occupational Health
S. Behzadinasaba, M. Hosseinia, M. D. Williamsb, H. M. Ivesterc, I. C. Allen, J. O. Falkinham, W. A. Duckera
Summary: The study demonstrates that cuprous oxide coatings have broad-spectrum antimicrobial activity against nine different micro-organisms. For example, the Cu2O/PU coating killed 99.9997% of Pseudomonas aeruginosa and 99.9993% of Staphylococcus aureus in 1 hour. These coatings maintained their efficacy after weekly cleanings and showed no cytotoxicity to human cells.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Medicine, General & Internal
Przemyslaw Karol Wolak, Agnieszka Strzelecka, Aneta Piotrowska, Katarzyna Dabrowska, Piotr Przemyslaw Wolak, Ilona Piotrowska, Grazyna Nowak-Starz
Summary: This study compared the operative time for unilateral inguinal hernia repair in children using open approach (OA) and Percutaneous Internal Ring Suturing (PIRS) methods. The results showed that the PIRS method was faster than OA, especially in female patients, suggesting it may be a preferred option for inguinal hernia repair in children.
JOURNAL OF CLINICAL MEDICINE
(2021)