Article
Infectious Diseases
Elena Priante, Chiara Minotti, Cristina Contessa, Margherita Boschetto, Paola Stano, Federico Dal Bello, Ettore De Canale, Elisabetta Lolli, Vincenzo Baldo, Eugenio Baraldi, Daniele Dona
Summary: This study reports the detection and control of an outbreak caused by ESBL-producing Klebsiella pneumoniae (ESBL-KP) in an Italian NICU. Prompt recognition of the event onset and the adoption of infection control interventions helped contain the bacteria spread on the ward. Multidisciplinary management and effective control measures were successful in preventing further cases and controlling the outbreak in a short period of time.
Article
Infectious Diseases
Agata Pruss, Pawel Kwiatkowski, Helena Masiuk, Iwona Bilska, Stefania Giedrys-Kalemba, Barbara Dolegowska
Summary: This study describes the successful containment and elimination of an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) in a neonatal ward. Through testing 26 neonates and 42 environmental swabs, it was confirmed that 18 neonates were colonized with ESBL-KP and developed infections. Strengthening hospital hygiene protocols, screening of hospitalized neonates, and cohorting ESBL-KP-positive patients proved effective in controlling and ending the outbreak.
Article
Infectious Diseases
Mohamed Belmahdi, Nadia Safia Chenouf, Abdelkrim Ait Belkacem, Sandra Martinez-Alvarez, Mario Sergio Pino-Hurtado, Zahra Benkhechiba, Samiha Lahrech, Ahcene Hakem, Carmen Torres
Summary: This study investigates the antimicrobial resistance and virulence threats of Escherichia coli isolates recovered from intestinal and fecal samples of chickens, turkeys, and sparrows. The study finds that sparrows could be a vector in the dissemination of ESBL-producing E. coli isolates to other environments. Additionally, this study reports the first detection of the bla(CTX-M-14) gene from sparrows at a global level and in turkeys in Algeria.
Article
Microbiology
Cecile Emeraud, Samy Figueiredo, Remy A. Bonnin, Mouna Khecharem, Souad Ouzani, Pierre-Etienne Leblanc, Agnes B. Jousset, Nicolas Fortineau, Jacques Duranteau, Laurent Dortet
Summary: Infections caused by ESBL-KP are on the rise globally and often lead to outbreaks in ICUs. Despite enhanced hygiene measures and prevention controls during the COVID-19 pandemic, an ESBL-producing K. pneumoniae isolate still caused a nosocomial outbreak in an ICU dedicated to COVID-19 patients.
Article
Immunology
Dariusz A. Hareza, Sara E. Cosgrove, Patricia J. Simner, Anthony D. Harris, Yehudit Bergman, Rick Conzemius, Emily Jacobs, Stephan Beisken, Pranita D. Tamma
Summary: This study investigated the clinical outcomes and optimal treatment methods for patients with ESBL-E bloodstream infections that do not produce CTX-M. The findings suggest that non-CTX-M and CTX-M ESBL-E infections are equally concerning and associated with similar clinical outcomes. Meropenem may be associated with improved survival in patients with non-CTX-M ESBL-E infections, highlighting the potential benefit of comprehensive molecular diagnostics for early antibiotic optimization in ESBL-E infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Kayode Fashae, Ines Engelmann, Stefan Monecke, Sascha D. Braun, Ralf Ehricht
Summary: The study in Ibadan, Nigeria revealed the presence of ESBL-producing E. coli in both wild birds and slaughtered cattle, indicating a potential for inter-species transmission and virulence. Guidelines balancing public health and habitat conservation are recommended, with continuous surveillance needed.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Satoshi Nishida, Masataka Nakagawa, Yuki Ouchi, Chiaki Sakuma, Yu Nakajima, Hisayo Shimizu, Takashi Shibata, Yasunori Kurosawa, Toshiaki Maruyama, C. J. Okumura, Nami Hatayama, Yoshinori Sato, Miwa Asahara, Shinobu Ishigaki, Taiji Furukawa, Teruo Akuta, Yasuo Ono
Summary: An LFIA based on an anti-CTX-M rabbit monoclonal antibody was developed for detecting CTX-M enzyme production in Enterobacterales, showing high sensitivity and specificity with clinical isolates. This LFIA has a low detection limit, 100% sensitivity and specificity with clinical isolates, and does not cross-react with other class A beta-lactamase producing bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Microbiology
Mehdi Sola, Yosra Mani, Estelle Saras, Antoine Drapeau, Raoudha Grami, Mahjoub Aouni, Jean-Yves Madec, Marisa Haenni, Wejdene Mansour
Summary: This study examined the presence of multi-drug resistant (MDR) bacteria in farmed fish and Mediterranean clams. The results suggest that bacteria from hospital or farm effluents can contaminate nearby seafood and fish, highlighting the importance of monitoring water quality and MDR bacteria in seafood.
Article
Microbiology
Edgar I. I. Campos-Madueno, Aline I. I. Moser, Peter M. M. Keller, Vincent Perreten, Laurent Poirel, Patrice Nordmann, Andrea Endimiani
Summary: KoC species overproduce OXY beta-lactamases, leading to reduced susceptibility to piperacillin-tazobactam, expanded-spectrum cephalosporins, and aztreonam. Whole-genome sequencing and susceptibility testing were used to characterize 44 KoC strains, showing phenotypic differences between ESBL producers and hyperproducers of OXYs. Only cefepime/cefepime-clavulanate combination disk tests or the double-disk synergy test could accurately distinguish between these two groups.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Microbiology
Lorena Montero, Jorge Irazabal, Paul Cardenas, Jay P. Graham, Gabriel Trueba
Summary: The majority of untreated wastewater, containing drug-resistant and pathogenic bacteria, is released into streams in cities around the world, potentially leading to the circulation of antibiotic-resistant bacteria back to humans through agricultural produce. This study conducted in Ecuador found ESBL-producing E. coli in irrigation water, vegetables, and fruits, with certain ESBL genes associated with human infections being prevalent. The presence of mcr-1 gene responsible for colistin resistance in some isolates highlights the potential role of irrigation water in the antimicrobial resistance crisis in Ecuador.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Kinga Toth, Akos Toth, Katalin Kamotsay, Viktoria Nemeth, Dora Szabo
Summary: This study reveals that ST131 clone, particularly C2/H30Rx and C1-M27 subclades, is the dominant clone of ESBL-producing E. coli collected in a hospital in Hungary.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2022)
Article
Microbiology
Shihan Zeng, Jiajun Luo, Xiaoyan Li, Chao Zhuo, Aiwu Wu, Xiankai Chen, LiShao Huang
Summary: The CTX-M-55 extended-spectrum beta-lactamase (ESBL)-positive rate has been increasing in recent years, showing resistance to ceftriaxone but sensitivity to ceftazidime, cefepime, and carbapenems among isolates with bla(CTX-M-55) gene. ST1193 is a common clone strain found carrying the bla(CTX-M-55) gene. The plasmids IncI1 and IncFII, along with mobile elements like ISEcp1 and IS26, may play a key role in the dissemination of CTX-M-55 genotypes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Lorena Lopez-Cerero, Emilio Stolz, Marina R. Pulido, Alvaro Pascual
Summary: This study reports the first occurrence of community cases of CTX-M-27-producing Shigella sonnei ST152 in Spain. These cases were resistant to quinolones and azithromycin and included both adult males and a pediatric case. The isolates were genetically similar to an Australian isolate and differed significantly from outbreak-causing strains in England.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Samiratu Mahazu, Wakana Sato, Alafate Ayibieke, Isaac Prah, Takaya Hayashi, Toshihiko Suzuki, Shiroh Iwanaga, Anthony Ablordey, Ryoichi Saito
Summary: The emergence and dissemination of ESBL-producing bacteria, particularly Enterobacteriaceae, have posed serious challenges to healthcare in Ghana. This study investigated the antimicrobial susceptibility and genetic characteristics of 164 Escherichia coli strains isolated from infected patients in two hospitals. It was found that 62.2% of the cefotaxime-resistant isolates were ESBL-producers, with ST131 being the dominant group. The ESBL-producers carried different ESBL alleles, with bla(CTX-M-15) being the most predominant. This study provides the first report on the phylogeny of ST131 in Ghana.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
F. Gravey, S. Wilson, A. Denisenko, C. Lehoussel, Marguerite Fines-Guyon, S. Le Hello, C. Jeanne-Leroyer
Summary: Whole genome sequencing is now the standard method used for microbiological investigations, enabling the detection of undisclosed outbreaks. By utilizing this approach, we were able to investigate and ultimately halt an uncommon epidemic caused by the extended-spectrum beta-lactamase-producing Klebsiella pneumoniae ST584 strain that spanned over four months in two intensive care units.
Article
Microbiology
Marina Oviano, Maria Jose Barba, Begona Fernandez, Adriana Ortega, Belen Aracil, Jesus Oteo, Jose Campos, German Bou
JOURNAL OF CLINICAL MICROBIOLOGY
(2016)
Article
Microbiology
Ana Gonzalez-Torralba, Jesus Oteo, Alejandra Asenjo, Veronica Bautista, Elisabeth Fuentes, Juan-Ignacio Alos
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Infectious Diseases
Ruben Tato-Rodriguez, Jesus Oteo-Iglesias, Patricia Alvarez-Garcia, Maria Jose Zamora-Lopez, Jesus Martinez-Lopez, Angeles Pallares-Gonzalez, Maria Victoria Pulian-Morais, Sara Fernandez-Romero, Ana Vindel-Hernando, Marta Garcia-Campello
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2016)
Review
Infectious Diseases
Jesus Oteo, German Bou, Fernando Chaves, Antonio Oliver
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2017)
Letter
Infectious Diseases
Victoria Ortiz de la Tabla, Adriana Ortega, Fernando Bunuel, Maria Perez-Vazquez, Borja Marcos, Jesus Oteo
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2017)
Article
Infectious Diseases
David M. Arana, Adriana Ortega, Eva Gonzalez-Barbera, Noelia Lara, Veronica Bautista, Dolores Gomez-Ruiz, David Saez, Sara Fernandez-Romero, Belen Aracil, Maria Perez-Vazquez, Jose Campos, Jesus Oteo
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2017)
Article
Public, Environmental & Occupational Health
A. Madueno, J. Gonzalez Garcia, S. Fernandez-Romero, J. Oteo, M. Lecuona
JOURNAL OF HOSPITAL INFECTION
(2017)
Article
Infectious Diseases
Hajo Grundmann, Corinna Glasner, Barbara Albiger, David M. Aanensen, Chris T. Tomlinson, Arjana Tambic Andrasevic, Rafael Canton, Yehuda Carmeli, Alexander W. Friedrich, Christian G. Giske, Youri Glupczynski, Marek Gniadkowski, David M. Livermore, Patrice Nordmann, Laurent Poirel, Gian M. Rossolini, Harald Seifert, Alkiviadis Vatopoulos, Timothy Walsh, Neil Woodford, Dominique L. Monnet, Petra Apfalter, Rainer Hartl, Youri Glupczynski, Te-Din Huang, Tanya Strateva, Yuliya Marteva-Proevska, Arjana Tambic Andrasevic, Iva Butic, Despo Pieridou-Bagatzouni, Panagiota Maikanti-Charalampous, Jaroslav Hrabak, Helena Zemlickova, Anette Hammerum, Lotte Jakobsen, Marina Ivanova, Anastasia Pavelkovich, Jari Jalava, Monica Osterblad, Sophie Vaux, Laurent Dortet, Martin Kaase, Soeren G. Gatermann, Alkiviadis Vatopoulos, Kyriaki Tryfinopoulou, Akos Toth, Laura Janvari, Teck Wee Boo, Elaine McGrath, Annalisa Pantosti, Monica Monaco, Arta Balode, Mara Saule, Jolanta Miciuleviciene, Aiste Mierauskaite, Monique Perrin-Weniger, Paul Reichert, Nina Nestorova, Sonia Debattista, Dorota Zabicka, Elzbieta Literacka, Manuela Canica, Vera Manageiro, Maria Damian, Brandusa Lixandru, Milan Niks, Eva Schreterova, Mateja Pirs, Tjasa Cerar, Jesus Oteo, Belen Aracil, Christian G. Giske, Karin Sjostrom, Neil Woodford, Katie Hopkins, Camilla Wiuff, Derek J. Brown, Hordur Hardarson, Orjan Samuelsen, Bjorg Haldorsen, Andi Koraqi, Denada Lacej, Lul Raka, Arsim Kurti, Gordana Mijovic, Milena Lopicic, Zora Jelesic, Anika Trudic, Ana Kraftandzieva, Elena Trajkovska-Dokic, Deniz Gur, Asli Cakar, Yehuda Carmeli, Amos Adler
LANCET INFECTIOUS DISEASES
(2017)
Letter
Infectious Diseases
Luis Lopez-Urrutia, Monica de Frutos, Jesus Oteo, Jose Maria Eiros
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
C. Cano Rodriguez, E. Castaner Gonzalez, M. Andreu Magarolas, X. Gallardo Cistare, A. Gonzalez Lopez, O. Cuevas Lobato, M. Gallego Diaz
Summary: This study retrospectively analyzed the epidemiology and CT findings of nontuberculous mycobacterial lung infections in 131 patients and evaluated the outcomes of different treatment approaches. The results showed that the diagnosis of nontuberculous mycobacterial lung infections is complex, and the clinical and radiological findings are often nonspecific. Additionally, a significant percentage of patients may have concomitant infections with other microorganisms.
Letter
Microbiology
Carmen Potel, Adriana Ortega, Lucia Martinez-Lamas, Veronica Bautista, Benito Regueiro, Jesus Oteo
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Public, Environmental & Occupational Health
Ana Madueno, Jonathan Gonzalez Garcia, Maria Jose Ramos, Yanet Pedroso, Zaida Diaz, Jesus Oteo, Maria Lecuona
AMERICAN JOURNAL OF INFECTION CONTROL
(2017)
Article
Infectious Diseases
Belen Aracil-Garcia, Jesus Oteo-Iglesias, Oscar Cuevas-Lobato, Noelia Lara-Fuella, Isabel Perez-Grajera, Sara Fernandez-Romero, Maria Perez-Vazquez, Jose Campos
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2017)
Article
Microbiology
Andres Esteban-Cantos, Belen Aracil, Veronica Bautista, Adriana Ortega, Noelia Lara, David Saez, Sara Fernandez-Romero, Maria Perez-Vazquez, Ferran Navarro, Hajo Grundmann, Jose Campos, Jesus Oteo
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)