期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 8, 页码 3484-3488出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00050-10
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资金
- INSERM [U914]
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
- Universite Paris XI, France
- European Community [HEALTH-F3-2008-223031]
- Ministerio de Educacion y Ciencia [2007/0292]
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III-FEDER, Spanish Network for Research in Infectious Diseases [REIPI RD06/0008]
An AmpC-type beta-lactamase conferring high-level resistance to expanded-spectrum cephalosporins and monobactams was characterized from an Acinetobacter baumannii clinical isolate. This class C beta-lactamase (named ADC-33) possessed a Pro210Arg substitution together with a duplication of an Ala residue at position 215 (inside the Omega-loop) compared to a reference AmpC cephalosporinase from A. baumannii. ADC-33 hydrolyzed ceftazidime, cefepime, and aztreonam at high levels, which allows the classification of this enzyme as an extended-spectrum AmpC (ESAC). Site-directed mutagenesis confirmed the role of both substitutions in its ESAC property.
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