Review
Medicine, General & Internal
Maria Leticia de Lima Machado, Amaxsell Thiago Barros Souza, Paula Vivian Andrade Linhares, Caio Fernando Martins Ferreira, David Franciole Oliveira Silva, Rand Randall Martins, Ricardo Ney Cobucci
Summary: Ivermectin has been proposed as a potential treatment for COVID-19, but there is limited evidence. This review aims to gather superior evidence on the effectiveness and safety of ivermectin. Methods include searching for randomized clinical trials and analyzing outcomes such as mortality, symptom resolution time, and adverse effects.
Review
Endocrinology & Metabolism
Julia Simoes Correa Galendi, Afonso Nogueira Simoes Correa Neto, Michelle Demetres, Cesar Luiz Boguszewski, Vania dos Santos Nunes Nogueira
Summary: This systematic review evaluated the efficacy and safety of various medications for treating Cushing's disease. While the proportion of disease control varied among different drugs, further research is needed to explore new therapeutic options for patients with limited treatment efficacy and tolerability.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nansi Lopez-Valverde, Beatriz Pardal-Pelaez, Antonio Lopez-Valverde, Javier Flores-Fraile, Silvia Herrero-Hernandez, Bruno Macedo-de-Sousa, Julio Herrero-Payo, Juan Manuel Ramirez
Summary: The natural product propolis has been shown to be effective and safe in treating periodontal disease. Research indicates that propolis can reduce probing pocket depth and improve treatment outcomes.
Review
Geriatrics & Gerontology
Xiaoyan Zheng, Yuyuan Tang, Qinghui Yang, Shuting Wang, Rouhao Chen, Chenyang Tao, Peiming Zhang, Baochao Fan, Jie Zhan, Chunzhi Tang, Liming Lu
Summary: The cognitive effectiveness of tau-targeting drugs for Alzheimer's disease (AD) is uncertain based on the current evidence. While selective inhibition of tau posttranslational modifications appears to have a statistical effect and be generally safer, further large-scale and well-designed trials are needed to explore the efficacy of different types of anti-tau drugs for AD.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Review
Pharmacology & Pharmacy
Shan Tang, Li Bai, Wei Hou, Zhongjie Hu, Xinyue Chen, Jing Zhao, Chen Liang, Wei Zhang, Zhongping Duan, Sujun Zheng
Summary: This study evaluated the efficacy and safety of common treatment regimens in patients with Wilson disease. The results showed that symptomatic patients treated with d-penicillamine had a higher incidence of adverse effects and neurological deterioration compared to those treated with zinc salts. The therapeutic effectiveness of these two regimens did not appear to be significantly different.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Geriatrics & Gerontology
Dawei Li, Jinlong Ma, Baojian Wei, Shuang Gao, Yanmei Lang, Xueying Wan
Summary: This meta-analysis compared the efficacy and safety of ginkgo biloba preparations combined with donepezil hydrochloride vs. donepezil for the treatment of Alzheimer's disease. The results showed that ginkgo biloba preparations plus donepezil can improve clinical effectiveness rate and vocabulary memory outcomes. However, more relevant high-quality RCTs are needed in the future to validate these results.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Tung Tang, Bo-Chueh Hsu, Der-Yuan Chen
Summary: This study demonstrates the effectiveness of COVID-19 vaccination in protecting rheumatic patients from severe illness. The immunogenicity of the vaccines is impaired in rheumatic patients but greatly enhanced after the second dose. Anti-CD20 therapy is associated with impaired humoral immunogenicity. Except for an increased incidence of arthralgia, adverse events due to COVID-19 vaccines in rheumatic patients are similar to those in healthy controls.
Review
Clinical Neurology
Emira Hodzic, Rodrigo Hasbun, Alejandro Granillo, Anna R. Troescher, Helga Wagner, Tim J. von Oertzen, Judith N. Wagner
Summary: This study presents a systematic review and meta-analysis on the use of steroids in viral encephalitis (VE), finding that there is no clear therapeutic effect of steroid treatment in VE patients.
JOURNAL OF NEUROLOGY
(2023)
Review
Medicine, General & Internal
Yonghui Hou, Baile Ning, Yamin Liu, Ying Liu, Wenbin Fu, Zehuai Wen
Summary: This systematic review will evaluate the effectiveness and safety of moxibustion therapy in the treatment of Parkinson's disease (PD). The findings may provide further evidence to support the use of moxibustion by clinicians.
Review
Medicine, General & Internal
Cristina Rubin de Celix, Maria Chaparro, Javier P. Gisbert
Summary: The study found that ustekinumab had good effectiveness and safety in Crohn's disease patients, but 18% of patients lost response during follow-up. Nearly one-third of the patients needed dose optimization, and it was effective in most cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Rheumatology
Zhivana Boyadzhieva, Nikolas Ruffer, Ina Koetter, Martin Krusche
Summary: The effectiveness and safety of current treatment strategies for VEXAS syndrome were evaluated in this study. The results showed that available treatments include the use of certain drugs and stem cell transplantation, but the data is limited and heterogeneous. Treatment decisions should be individualized and clinical trials are needed to develop treatment algorithms. Adverse events, especially the elevated risk of venous thromboembolism associated with JAKi treatment, remain a challenge.
Review
Medicine, General & Internal
Mingtai Chen, Guofu Zhong, Junteng Chen, Ling Men, Jienan Luan, Zhihao Luo
Summary: This article presents a systematic review and meta-analysis aiming to assess the effectiveness and safety of Tiaogan formula in patients with coronary heart disease (CHD). The study will conduct a systematic search and data synthesis, and evaluate the quality of evidence using a rigorous assessment system.
Review
Geriatrics & Gerontology
Xin-Tong Su, Ning Sun, Na Zhang, Li-Qiong Wang, Xuan Zou, Jin-Lig Li, Jing-Wen Yang, Guang-Xia Shi, Cun-Zhi Liu
Summary: This review of 48 RCTs found that acupuncture is beneficial for cognitive function and daily performance in VCI patients compared to Western medicine and usual care, with no significant difference in adverse event occurrence. However, due to the poor quality and significant heterogeneity among studies, the certainty of evidence is low or very low.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Integrative & Complementary Medicine
Kyou-Hwan Han, Ki Haeng Cho, Caroline Han, Shanqin Cui, Lily Lin, Ho -Yu Baek, Jaejong Kim
Summary: This systematic review suggests that acupuncture is significantly effective and safe compared to analgesics in the treatment of sciatica, and further rigorous studies are needed to validate its effectiveness and safety.
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Review
Virology
Nurizzati Sudarmaji, Nurolaini Kifli, Andi Hermansyah, Siang Fei Yeoh, Bey-Hing Goh, Long Chiau Ming
Summary: This study systematically reviewed preclinical studies on monkeypox treatment and immunization. The results showed that tecovirimat and brincidofovir are potential treatment drugs, while live smallpox/monkeypox vaccine demonstrated good immunogenicity. Third-generation smallpox vaccines, such as JYNNEOS and Lc16m8, have shown improved safety compared to earlier generations.