期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 54, 期 3, 页码 1323-1326出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00812-09
关键词
-
资金
- Swiss National Science Foundation [310030-116257]
- Cubist Pharmaceuticals
- Lexington
- MA
- Novartis Pharma Schweiz
- AG
- Bern
- Switzerland
Antibiotic-induced bacteriolysis exacerbates inflammation and brain damage in bacterial meningitis. Here the quality and temporal kinetics of cerebrospinal fluid (CSF) inflammation were assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone. Daptomycin led to lower CSF concentrations of interleukin 1 beta (IL-1 beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1 alpha) (P < 0.05). In experimental pneumococcal meningitis, daptomycin treatment resulted in more rapid bacterial killing, lower CSF inflammation, and less brain damage than ceftriaxone treatment.
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