Article
Immunology
Mariana Castanheira, Rodrigo E. Mendes, Ana C. Gales
Summary: The Acinetobacter baumannii-calcoaceticus complex (ABC) is a significant group of organisms causing human infections worldwide, with a small number of clones responsible for increased infections and resistance to antimicrobial agents. This article discusses the current epidemiology and resistance mechanisms in ABC. A. baumannii-calcoaceticus is the most common species in the Acinetobacter genus and is responsible for a large percentage of nosocomial infections, including bacteremia, pneumonia, and skin and urinary tract infections. Key clones of A. baumannii-calcoaceticus play a major role in the global dissemination of these organisms, and multidrug resistance is a common trait among these clones due to their remarkable adaptability. A. baumannii-calcoaceticus isolates can develop resistance through various mechanisms, such as horizontal gene transfer, natural transformation, acquisition of mutations, and mobilization of genetic elements.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Neveen M. Saleh, Sarah I. Saad, Mohamed El-Sayed, Gharieb S. El-Sayyad, Feriala A. Abo Safe
Summary: The overuse of antibiotics for infection treatment has led to the rapid spread of multi-drug resistance Acinetobacter baumannii in hospitals. In our study, we evaluated the contribution of aminoglycoside resistance mechanisms in A. baumannii to the resistance surge in selected Egyptian hospitals. The analysis revealed a multidrug-resistant pattern and limited susceptibilities to aminoglycosides, highlighting the alarming levels of aminoglycoside resistance in A. baumannii isolates.
MICROBIAL PATHOGENESIS
(2023)
Article
Microbiology
Amy K. Cain, Mehrad Hamidian
Summary: Antibiotic resistance is a growing global concern, especially in the case of Acinetobacter baumannii, a highly antibiotic-resistant pathogen causing various infections. The global spread of antibiotic-resistant strains of A. baumannii has led to limited treatment options, increased morbidity and mortality rates, longer hospital stays, and higher healthcare costs. A. baumannii employs clever strategies such as horizontal gene transfer, overexpression of efflux pumps, mutations, and natural selection to develop antibiotic resistance, making infections caused by this pathogen challenging to control and treat. Addressing this problem requires increased surveillance, strict infection control measures, and the development of new treatment strategies through collaboration among healthcare professionals, researchers, and policymakers.
Article
Microbiology
James A. Karlowsky, Meredith A. Hackel, Sarah M. McLeod, Alita A. Miller
Summary: Sulbactam-durlobactam demonstrated potent antibacterial activity against geographically diverse clinical isolates of Acinetobacter baumannii-calcoaceticus complex (ABC), including carbapenem-non-susceptible and multidrug-resistant (MDR) isolates.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Larissa de O. Camargo, Inglid Fontoura, Thais S. Veriato, Leandro Raniero, Maiara L. Castilho
Summary: This study aimed to develop a nanodrug using AgNPs functionalized with Amikacin to combat multidrug-resistant Acinetobacter baumannii. The results demonstrated that AgNPs@Amikacin effectively inhibited and killed Amikacin-resistant Acinetobacter baumannii, and reduced the metabolic activity of its biofilm. The new nanodrug showed promising potential with lower concentrations, less toxicity, and greater efficacy.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Microbiology
Emma Taylor, Elita Jauneikaite, Shiranee Sriskandan, Neil Woodford, Katie L. Hopkins
Summary: This study identified the occurrence of the 16S RMTase gene armA in Acinetobacter baumannii isolates from the UK and the Republic of Ireland. It also discovered a new variant of the rmtE gene, rmtE3. The majority of armA-positive isolates belonged to international clone II (ST2), while the rmtE3-positive isolate belonged to ST79.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Infectious Diseases
Jacqueline Findlay, Patrice Nordmann, Maxime Bouvier, Auriane Kerbol, Laurent Poirel
Summary: This study investigated the spread and emergence of A. baumannii clones co-producing OXA-23 and ArmA in Switzerland. The majority of the isolates were obtained from infections and belonged to the high-risk GC-2 clone. Monitoring and control of these MDR A. baumannii strains are crucial to prevent further spread.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Sukrit Srisakul, Dhammika Leshan Wannigama, Paul G. Higgins, Cameron Hurst, Shuichi Abe, Parichart Hongsing, Thammakorn Saethang, Sirirat Luk-in, Tingting Liao, Naris Kueakulpattana, Aye Mya Sithu Shein, Lin Gan, Rosalyn Kupwiwat, Chanikan Tanasatitchai, Pattama Wapeesittipan, Phatthranit Phattharapornjaroen, Vishnu Nayak Badavath, Asada Leelahavanichkul, Tanittha Chatsuwan
Summary: This study focused on colistin-resistant Acinetobacter baumannii (CoR-AB) and its prevalence, resistance mechanisms, and the efficacy of colistin plus sulbactam combination therapy against CoR-AB isolates. The study found that the resistance rate of colistin among carbapenem-resistant A. baumannii was 15.14%. The mechanisms of resistance were associated with overexpression of the phosphoethanolamine transferase (PmrC) due to amino acid substitutions in PmrB. In addition, the study showed that the combination therapy of colistin plus sulbactam exhibited excellent synergistic activity against CoR-AB isolates.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Ghazal Naderi, Malihe Talebi, Roghayeh Gheybizadeh, Arash Seifi, Sedigheh Ghourchian, Mohammad Rahbar, Alireza Abdollahi, Abdolhossein Naseri, Parisa Eslami, Masoumeh Douraghi
Summary: Our study aimed to identify the mobile genetic elements (MGEs) associated with aminoglycoside resistance in global clone 2 (GC2) A. baumannii. Among the 315 A. baumannii isolates, 97 were identified as GC2. Among the GC2 isolates, 53.6% showed resistance to all tested aminoglycosides. The MGEs carrying armA, aphA6, aphA1b, and aadB were detected in a significant number of GC2 isolates, indicating their role in the spread of aminoglycoside resistance genes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Rania Kishk, Nourhan Soliman, Nader Nemr, Raghda Eldesouki, Nageh Mahrous, Adil Gobouri, Ehab Azab, Maha Anani
Summary: The study revealed a high frequency of genes encoding AME in A. baumannii strains isolated from ICU, with aacC1 gene being the predominant resistance gene. This emphasizes the importance of preventive measures to control the spread of resistance genes.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Ophthalmology
Kenneth K. H. Lai, Sarah Wang, Andrew K. T. Kuk, Alan Tsang, Jacqueline H. C. Tai, Callie K. L. Ko
Summary: Acinetobacter baumannii-calcoaceticus complex is a common cause of hospital-acquired infections, including orbital cellulitis. This study presents a case of orbital cellulitis caused by the A. baumannii-calcoaceticus complex, which was successfully treated with antibiotics.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Infectious Diseases
Mohammad Hamidian, Stephanie J. Ambrose, Grace A. Blackwell, Steven J. Nigro, Ruth M. Hall
Summary: An early carbapenem-susceptible Acinetobacter baumannii outbreak in Australia was caused by an unusual strain that had acquired plasmids carrying antibiotic resistance genes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Microbiology
Leili Osanloo, Habib Zeighami, Fakhri Haghi, Reza Shapouri, Rasoul Shokri
Summary: Acinetobacter baumannii is a major cause of nosocomial infections and has high mortality rates in hospitalized patients. Molecular typing methods such as ERIC-PCR and MLVA are effective in assessing the clonal relation and managing outbreaks of A. baumannii isolates. The isolates showed multidrug resistance, with a high percentage being extensively drug-resistant.
CURRENT MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
M. John Albert, Ghayda Al Hashem, Vincent O. Rotimi
Summary: The study validated the gyrB PCR assay for easy identification of Acinetobacter baumannii through comparison with whole genome sequence-based assays.
MEDICAL PRINCIPLES AND PRACTICE
(2022)
Article
Microbiology
Christopher J. J. Harmer, Steven J. J. Nigro, Ruth M. M. Hall
Summary: The aminoglycoside resistance gene aac(6')-Im is prevalent in the globally distributed resistant clones of Acinetobacter baumannii. It commonly coexists with the gene aacC1 in the global clone 2 (GC2) of A. baumannii. Understanding the dissemination and evolution of aac(6')-Im gene is important for tracking specific lineages and sublineages formation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Behavioral Sciences
Christopher M. Barkley, Zhenhong Hu, Ann M. Fieberg, Lynn E. Eberly, Angela K. Birnbaum, Ilo E. Leppik, Susan E. Marino
Summary: Linear mixed effects models revealed an increase in theta power in response to TPM administration. Regression models showed robust relationships between baseline rsEEG parameters and TPM-related, but not LZP-related, WM impairment. These findings suggest potential novel clinical applications for rsEEG measures in the future.
EPILEPSY & BEHAVIOR
(2021)
Article
Endocrinology & Metabolism
Evan Olawsky, Yuan Zhang, Lynn E. Eberly, Erika S. Helgeson, Lisa S. Chow
Summary: This article presents a new R package and companion web app for quick and easy computation of a suite of glycemic variability metrics.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2022)
Article
Clinical Neurology
Pavel Filip, Petr Bednarik, Lynn E. Eberly, Amir Moheet, Alena Svatkova, Heidi Grohn, Anjali F. Kumar, Elizabeth R. Seaquist, Silvia Mangia
Summary: The choice of software version in neuroimaging pipelines can significantly impact the results of research studies. This study investigated the differences in inferences and statistical significances when comparing volumetric parameters between healthy controls and type 1 diabetes patients using different versions of FreeSurfer. The findings revealed varying levels of differences in volume measurements depending on the software version used, highlighting the importance of considering software validation and quality control in neuroimaging research.
Article
Multidisciplinary Sciences
Alberto Herrero Babiloni, Fernando G. Exposto, Connor M. Peck, Bruce R. Lindgren, Marc O. Martel, Christophe Lenglet, David A. Bereiter, Lynn E. Eberly, Estephan J. Moana-Filho
Summary: This study aimed to determine if short-term jaw pain fluctuations can serve as a clinical marker for the impact status of TMD pain. The results showed that high-impact pain patients experienced more frequent jaw pain fluctuations, and there was no association between jaw pain intensity and pressure pain thresholds.
SCIENTIFIC REPORTS
(2022)
Article
Statistics & Probability
Bin Guo, Lynn E. Eberly, Pierre-Gilles Henry, Christophe Lenglet, Eric F. Lock
Summary: This article develops a general framework for multiway classification that is applicable to any number of dimensions and any degree of sparsity. Extensive simulation studies show that the model is robust to the degree of sparsity and improves classification accuracy when the data have multiway structure.
JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS
(2023)
Article
Geriatrics & Gerontology
Ilo E. Leppik, Angela K. Birnbaum, Kenneth Svensden, Lynn E. Eberly
Summary: The incidence of epilepsy/seizure in older adult nursing home residents is high, with the highest occurrence in the first year after admission. Men have a higher incidence compared to women, and younger residents have a higher incidence compared to older residents.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Nicole Zarate, Katherine Gundry, Dahyun Yu, Jordan Casby, Lynn E. Eberly, Gulin Oz, Rocio Gomez-Pastor
Summary: This study investigates the association between neurochemical alterations and changes in synapse density in a mouse model of Huntington's disease (HD). The findings suggest that early synaptic loss precedes excitatory synapse density reduction in HD, and the loss of CK2 alpha' kinase can rescue this synaptic loss. Furthermore, the study identifies positive correlations between excitatory synapse number and levels of specific neurochemicals, providing a potential approach for monitoring the effects of potential treatments for HD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Connor M. Peck, David A. Bereiter, Lynn E. Eberly, Christophe Lenglet, Estephan J. Moana-Filho
Summary: High-impact temporomandibular disorder (TMD) pain participants showed abnormal brain responses to sensory processing of noxious stimuli, indicating the presence of maladaptive brain plasticity in chronic TMD pain.
Correction
Clinical Neurology
Young Woo Park, James M. Joers, Bin Guo, Diane Hutter, Khalaf Bushara, Isaac M. Adanyeguh, Lynn E. Eberly, Gulin Oz, Christophe Lenglet
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Ivan Tkac, Tiankai Xie, Nitya Shah, Sarah Larson, Janet M. Dubinsky, Rocio Gomez-Pastor, Hayley S. McLoughlin, Harry T. Orr, Lynn E. Eberly, Gulin Oz
Summary: Sex differences in neurochemical concentrations in healthy mice have been found, with higher concentrations in male mice compared to female mice in most brain regions. These differences are small but significant and are dependent on age. The hypothalamus displays a different pattern of sex differences in neurochemical levels compared to other brain regions, possibly due to differences in energy metabolism and cellular density.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Isaac M. Adanyeguh, James M. Joers, Dinesh K. Deelchand, Diane H. Hutter, Lynn E. Eberly, Bin Guo, Isabelle Iltis, Khalaf O. Bushara, Pierre-Gilles Henry, Christophe Lenglet
Summary: This study investigated the longitudinal brain alterations in early-stage Friedreich ataxia using multimodal neuroimaging. The results showed macrostructural and microstructural changes in the brain, especially in the cerebellum, and demonstrated their progression over time. These findings provide important insights into the pathophysiology and progression of Friedreich ataxia.
BRAIN COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Mohamed S. Fayed, Jillian Brooks, Elizabeth R. Seaquist, Anjali Kumar, Amir Moheet, Lynn Eberly, Usha Mishra, Lisa D. Coles
Summary: In this study, the pharmacokinetics of N-acetylcysteine (NAC) and its effects on oxidative stress were evaluated using a randomized, double-blinded, placebo-controlled crossover design. The results showed that NAC can rapidly increase circulating cysteine concentration and temporarily decrease plasma glutathione (GSH) concentration.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2023)
Article
Clinical Neurology
James M. Joers, Isaac M. Adanyeguh, Dinesh K. Deelchand, Diane H. Hutter, Lynn E. Eberly, Isabelle Iltis, Khalaf O. Bushara, Christophe Lenglet, Pierre-Gilles Henry
Summary: In this study, the authors used magnetic resonance imaging and spectroscopy to evaluate the cross-sectional alterations and longitudinal changes in the cervical spinal cord of patients with early-stage Friedreich ataxia. The findings showed that there were significant changes in spinal cord size, microstructure, and neurochemistry in these patients, and disease progression could be monitored non-invasively.
BRAIN COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Nathan T. Rubin, Elizabeth R. Seaquist, Lynn Eberly, Anjali Kumar, Silvia Mangia, Gulin Oz, Amir Moheet
Summary: This study aimed to investigate the relationship between impaired awareness of hypoglycemia (IAH) and questionnaires, as well as the symptom and hormonal responses to hypoglycemia. The results showed inconsistent classification of IAH between the Clarke and Gold questionnaires and poor prediction of hypoglycemia awareness status on both questionnaires in subjects with type 1 diabetes and moderate blunting of symptoms or epinephrine response.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Endocrinology & Metabolism
Yuan Zhang, Gulin Oz, Amir Moheet, Anjali Kumar, Alison Alvear, Silvia Mangia, Lynn Eberly, Elizabeth R. Seaquist
Summary: The study aimed to investigate the predictive value of epinephrine and symptom response to the first episode of hypoglycemia in predicting the development of hypoglycemia-associated autonomic failure (HAAF) in volunteers with type 1 diabetes and healthy controls. The results showed heterogeneity in the response to the hypoglycemia induction protocol, with higher epinephrine levels observed in those who developed HAAF.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
