Article
Multidisciplinary Sciences
Trang T. Nguyen, Rodolfo Ghirlando, Julien Roche, Vincenzo Venditti
Summary: Enzyme I (EI) is a phosphotransferase enzyme responsible for converting phosphoenolpyruvate (PEP) into pyruvate in the bacterial phosphotransferase (PTS) transduction pathway. By mutating the dimerization domain of EI (EIC) and applying hydrostatic pressure to study the dissociation process, researchers were able to characterize the monomeric state of EI at atomic level. The study reveals the role of catalytic loops as allosteric connectors controlling both the activity and oligomerization of the enzyme.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Xiaojing Duan, Zhonglong Zhu, Yang Yang, Jie Duan, Zhongkui Jia, Faju Chen, Ziyang Sang, Luyi Ma
Summary: The research found that salicylic acid can promote natural cold acclimation in Magnolia wufengensis, ultimately enhancing winter hardiness and improving freezing tolerance by increasing the accumulation of soluble sugars. The enhanced accumulation of glucose, fructose, and raffinose can contribute to the development of cold acclimation and improve plant cold resistance.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Agriculture, Multidisciplinary
Kai Lu, Yibei Cheng, Yimin Li, Wenru Li, Rensen Zeng, Yuanyuan Song
Summary: The study revealed that pre-exposure to the flavonoid phytochemical flavone enhances larval tolerance to multiple synthetic insecticides and activates detoxification enzyme activities through the ROS/CncC pathway. The findings suggest a key role of the ROS/CncC pathway in driving detoxification gene expression responsible for insecticide tolerance after exposure to flavone.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Lei Liu, Yanchao Sun, Pengcheng Di, Yakun Cui, Qingchang Meng, Xiaming Wu, Yanping Chen, Jianhua Yuan
Summary: The maize brassinosteroid-signaling kinase gene ZmBSK1 plays a significant role in the response to salt stress. Overexpression of ZmBSK1 improves salt tolerance in maize by reducing cellular damage and oxidative stress and modulating the expression of antioxidant defense enzymes and proline biosynthesis-related genes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Shuang Zhao, Haibo Wang, Xumei Jia, Hanbing Gao, Ke Mao, Fengwang Ma
Summary: The study revealed that the MdHB7-like gene in apple is induced under salt stress, and overexpression of this gene enhances salt tolerance in apple plants by improving photosynthetic performance, reducing ROS and Na+ accumulation, and increasing proline and soluble sugars accumulation. These findings highlight the important role of MdHB7-like as a regulator of salt tolerance in apple and provide potential insights for molecular breeding research.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Multidisciplinary Sciences
Evan J. Brettrager, Selma M. Cuya, Zachary E. Tibbs, Jun Zhang, Charles N. Falany, Stephen G. Aller, Robert C. A. M. van Waardenburg
Summary: The N-terminal domain (NTD) of Tdp1, which is understudied and poorly conserved, plays a critical role in the removal of TOP1-DNA adducts in cells. It is proposed that the NTD serves as a regulatory domain, coordinating the stabilization of the DNA-adducted end and facilitating hydrolysis.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Xingxing Li, Bo Yu, Qi Wu, Qian Min, Rongfeng Zeng, Zizhao Xie, Junli Huang
Summary: OsMADS23 functions as a positive regulator in response to osmotic stress via ABA signaling. OsMADS23 directly activates the transcription of target genes OsNCED2, OsNCED3, OsNCED4 and OsP5CR that are key components for ABA and proline biosynthesis. More importantly, the SnRK2-type protein kinase SAPK9 physically interacts with and phosphorylates OsMADS23, and increases its stability and transcriptional activity, in an ABA-dependent manner.
Article
Infectious Diseases
Haruno Yoshida, Takashi Takahashi, Hidenori Matsui
Summary: The study indicates that a spontaneous point mutation in the rocA gene may have led to the highly virulent phenotype of M1 GAS. Infection with MTB313 or MAT100 resulted in higher mortalities in CD46 Tg mice, while MTB314 or MAT101 showed lower hyaluronic acid (HA) production.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Bhavya S. Doshi, Jyoti Rana, Giancarlo Castaman, Mostafa A. Shaheen, Radoslaw Kaczmarek, John S. S. Butterfield, Shannon L. Meeks, Cindy Leissinger, Moanaro Biswas, Valder R. Arruda
Summary: Inhibitors of factor VIII (FVIII) in hemophilia A are a challenging complication of FVIII protein replacement therapy. Research suggests that BAFF may play a role in regulating the generation and maintenance of FVIII inhibitors, and anti-BAFF therapy could prevent the formation of inhibitors. Combination therapy with anti-CD20 and anti-BAFF antibodies shows promise in significantly reducing FVIII inhibitors.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Aadil Yousif, Rashid Mir, Jamsheed Javid, Jameel Barnawi, Mohammed M. Jalal, Malik A. Altayar, Salem Owaid Albalawi, Faisel M. Abuduhier
Summary: This study developed a T-ARMS-based PCR assay for genotyping ACE1-rs4646996 and ACE2-rs4240157 and investigated their association with coronary artery disease (CAD). The results showed significant differences in ACE1-rs4646996 and ACE2-rs4240157 genotypes between CAD patients and controls, and these genotypes were associated with CAD susceptibility. Additionally, ACE2 genotypes were found to be associated with hypertension, type 2 diabetes, and obesity. The findings suggest that the developed assay can be a potential molecular tool for genetic disease diagnosis, especially in resource-limited settings.
Article
Microbiology
Rabia Ladjouzi, Alain Bizzini, Willem van Schaik, Xinglin Zhang, Alain Rince, Abdellah Benachour, Axel Hartke
JOURNAL OF BACTERIOLOGY
(2015)
Article
Public, Environmental & Occupational Health
Laurence Rochat, Alain Bizzini, Nicolas Senn, Pierre-Yves Bochud, Blaise Genton, Serge de Valliere
JOURNAL OF TRAVEL MEDICINE
(2015)
Article
Immunology
Alain Bizzini, Olivier Peter, David Baud, Sophie Edouard, Pascal Meylan, Gilbert Greub
MICROBES AND INFECTION
(2015)
Article
Microbiology
Myriam K. S. Ballo, Sami Rtimi, Cesar Pulgarin, Nancy Hopf, Aurelie Berthet, John Kiwi, Philippe Moreillon, Jose M. Entenza, Alain Bizzini
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2016)
Article
Biotechnology & Applied Microbiology
Myriam K. S. Ballo, Sami Rtimi, Stefano Mancini, John Kiwi, Cesar Pulgarin, Jose M. Entenza, Alain Bizzini
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Myriam K. S. Ballo, Sami Rtimi, John Kiwi, Cesar Pulgarin, Jose M. Entenza, Alain Bizzini
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2017)
Editorial Material
Medicine, General & Internal
Riat Arnaud, Neofytos Dionysios, Coste T. Alix, Harbarth Stephan, Bizzini Alain, Grandbastien Bruno, Pugin Jerome, Lamoth Frederic
SWISS MEDICAL WEEKLY
(2018)
Article
Immunology
Olivier Clerc, Guy Prod'hom, Christelle Vogne, Alain Bizzini, Thierry Calandra, Gilbert Greub
CLINICAL INFECTIOUS DISEASES
(2013)
Article
Infectious Diseases
Rabia Ladjouzi, Alain Bizzini, Francois Lebreton, Nicolas Sauvageot, Alain Rince, Abdellah Benachour, Axel Hartke
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2013)
Article
Microbiology
J. M. Entenza, B. Betrisey, O. Manuel, M. Giddey, O. Sakwinska, F. Laurent, A. Bizzini
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Biochemical Research Methods
Giovanni Longo, Laura Marques Rio, Andrej Trampuz, Giovanni Dietler, Alain Bizzini, Sandor Kasas
JOURNAL OF MICROBIOLOGICAL METHODS
(2013)
Article
Infectious Diseases
Laura Rio-Marques, Axel Hartke, Alain Bizzini
MICROBIAL DRUG RESISTANCE
(2014)
Article
Microbiology
Chen Zhao, Alain Bizzini, Xiaolin Zhang, Nicolas Sauvageot, Axel Hartke
Article
Nanoscience & Nanotechnology
G. Longo, L. Alonso-Sarduy, L. Marques Rio, A. Bizzini, A. Trampuz, J. Notz, G. Dietler, S. Kasas
NATURE NANOTECHNOLOGY
(2013)
Article
Cell & Tissue Engineering
Martin Clauss, Ulrika Furustrand Tafin, Alain Bizzini, Andrej Trampuz, Thomas Ilchmann
EUROPEAN CELLS & MATERIALS
(2013)