Article
Microbiology
Lotte Jakobsen, Carina Vingsbro Lundberg, Niels Frimodt-Moller
Summary: Ciprofloxacin is highly effective in clearing urine and kidney tissue for fully susceptible E. coli, but not for low-level resistant strains. PKPD correlations show a higher correlation between AUC/MIC and effect in urine and kidneys, while %T->MIC shows a lower correlation.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Siwei Guo, Xin Li, You Li, Huan Tong, Minji Wei, Bingqian Yan, Miaomei Tian, Bing Xu, Jing Shao
Summary: Sitafloxacin fumarate injection is an alternative therapeutic agent for the treatment of UTIs caused by MDR isolates. The study shows that Sitafloxacin has lower MICs compared to levofloxacin and has a high probability of achieving target attainment in common complicated urinary tract infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Jude Fonbah Leinyuy, Innocent Mbulli Ali, Karimo Ousenu, Christopher B. Tume
Summary: This study analyzed 200 Enterobacteriaceae isolates resistant and susceptible to ESBL, quinolones, and aminoglycosides. It found a high carriage of resistance genes, but the carriage of resistance genes may not always be correlated with phenotypic expression.
Article
Infectious Diseases
Lawrence P. Belotindos, Risa Tsunoda, Marvin A. Villanueva, Chie Nakajima, Claro N. Mingala, Yasuhiko Suzuki
Summary: This study investigated the presence of qnr-carrying plasmids in Escherichia coli isolated from the food supply chain. The findings showed that these plasmids can spread through selective pressure with quinolones or other antimicrobials. Therefore, prudent use of antimicrobials in animal production and stricter hygiene and food handling are recommended to prevent the emergence and spread of qnr-harboring bacteria.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Ga Eun Park, Jae-Hoon Ko, Sun Young Cho, Hee Jae Huh, Jin Yang Baek, Kwan Soo Ko, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck
Summary: This study evaluated the clinical outcomes of bacteremic urinary tract infection patients caused by Enterobacteriaceae with reduced susceptibility to ciprofloxacin. Results showed that reduced ciprofloxacin susceptibility did not lead to poorer clinical outcomes, suggesting the need for further evaluation to guide the selection of appropriate antibiotics for urinary tract infections.
Article
Infectious Diseases
Hongying Zhu, Yanhui Chen, Yaping Hang, Hong Luo, Xueyao Fang, Yanping Xiao, Xingwei Cao, Shan Zou, Xiaoyan Hu, Longhua Hu, Qiaoshi Zhong
Summary: This retrospective cohort study in a tertiary hospital in southern China found that inappropriate empirical antibiotic treatment for urinary tract infections caused by E. coli was associated with longer hospital length of stay. Empirical use of fluoroquinolones for UTIs should be avoided to reduce healthcare costs and bacterial resistance.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Immunology
Mohamed Kettani Halabi, Fatima Azzahra Lahlou, Idrissa Diawara, Younes El Adouzi, Rabiaa Marnaoui, Rachid Benmessaoud, Imane Smyej
Summary: ESBL-EC infections pose challenges due to limited treatment options, increased hospital costs, reduced microbiological and clinical responses, and a threat to patient's life. Majority of ESBL-EC isolates were from female adult patients over 50, resistant to third-generation cephalosporins and quinolones, but sensitive to carbapenems and fosfomycin.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Dehong Cao, Yinzhi Shen, Yin Huang, Bo Chen, Zeyu Chen, Jianzhong Ai, Liangren Liu, Lu Yang, Qiang Wei
Summary: Systematic review and meta-analysis showed that levofloxacin and ciprofloxacin have similar efficacy for the treatment of urinary tract infections, and both drugs are safe for clinical use.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Debojyoty Bandyopadhyay, Mandira Mukherjee
Summary: This study validated ZINC000104153710 and ZINC000000217308 as potent inhibitors of bacterial UspA function and indicated their potential as alternative therapeutics to combat the MDR-UPEC.
JOURNAL OF ANTIBIOTICS
(2022)
Article
Public, Environmental & Occupational Health
Erastus H. Haindongo, Binta Funtua, Boni Singu, Marius Hedimbi, Francis Kalemeera, Jana Hamman, Olli Vainio, Antti J. Hakanen, Jaana Vuopio
Summary: This study aimed to describe the national antimicrobial resistance situation of major bacterial uropathogens in females within the 14 Namibian regions. High resistance to ampicillin, quinolones, and sulfamethoxazole-trimethoprim among E. coli was reported, with concerning rates of resistance to third-generation cephalosporins at 22%.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Engineering, Biomedical
Shi Wenjie, An Jinxia, Tan He, Jia Mengran, Gao Hui
Summary: This study developed a low-temperature photothermal nanoplatform for the treatment of urinary tract infections (UTIs), which showed excellent photothermal bactericidal effects. The nanoplatform achieved targeted action against uropathogenic Escherichia coli (UPEC) through its high affinity, avoiding damage to surrounding healthy tissue.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Immunology
Marzie Mahdizade Ari, Shirin Dashtbin, Fatemeh Ghasemi, Soheila Shahroodian, Parisa Kiani, Elnaz Bafandeh, Talieh Darbandi, Roya Ghanavati, Atieh Darbandi
Summary: Nitrofurantoin has been widely used to treat urinary tract infections since 1953 as it remains active against drug-resistant uropathogens. It is now considered the first-line therapy for uncomplicated lower urinary tract infection. However, the excessive use of fluoroquinolones for treating uncomplicated UTI is deemed inappropriate and harmful, leading us to hypothesize that Nitrofurantoin may be the best choice due to its low utilization and high susceptibility. While it is the most effective drug for acute urinary infection, criteria for prescribing Nitrofurantoin in chronic UTI cases are needed due to its long-term side effects, especially in elderly patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Kevin Kariuki, Mame Mareme Diakhate, Susan Musembi, Stephanie N. Tornberg-Belanger, Doreen Rwigi, Timothy Mutuma, Elizabeth Mutuku, Kirkby D. Tickell, Olusegun O. Soge, Benson O. Singa, Judd L. Walson, Patricia B. Pavlinac, Samuel Kariuki
Summary: This study investigated the prevalence of fluoroquinolone resistance in E. coli and Klebsiella spp isolated from children discharged from two hospitals in Kenya. The findings showed a high proportion of isolates that were non-susceptible to ciprofloxacin and carried multiple resistance genes. This suggests that discharged children may play a significant role in the transmission of antimicrobial-resistant bacteria to the community, highlighting the need for enhanced surveillance and interventions to control the spread of resistant bacteria.
Article
Microbiology
Lei Huang, Chenwei Huang, Yan Yan, Liying Sun, Haixia Li
Summary: This study compared the etiological profiles and antibiotic resistance patterns of urinary tract infections (UTIs) sorted by different age categories. The study found that the pathogens and antibiotic resistance varied among different age groups, especially in pediatric and geriatric patients. Therefore, different antibiotic therapies should be considered for different age categories when initiating empirical antimicrobial therapies.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Taylor M. Benavides, James K. Aden, Stephanie E. Giancola
Summary: This study found a correlation between minimum inhibitory concentration (MIC) of fluoroquinolones and outcomes in patients with urinary tract infections (UTIs) caused by Enterobacterales pathogens. Higher MIC was associated with a higher risk of UTI recurrence.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Emmanuelle Cambau, Isabelle Durand-Zaleski, Stephane Bretagne, Christian Brun-Buisson, Catherine Cordonnier, Xavier Duval, Stephanie Herwegh, Julien Pottecher, Rene Courcol, Sylvie Bastuji-Garin
INTENSIVE CARE MEDICINE
(2017)
Article
Pharmacology & Pharmacy
Celia Lloret-Linares, Stephane Mouly, Dan-Tranh Hoang-Nguyen, John Evans, Laurent Raskine, Amanda Lopes, Emmanuelle Cambau, Jean-Francois Bergmann, Pierre Sellier
ANNALS OF PHARMACOTHERAPY
(2013)
Article
Microbiology
T. Guillard, E. Cambau, F. Chau, L. Massias, C. de Champs, B. Fantin
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2013)
Article
Microbiology
Nicolas Radomski, Adelaide Roguet, Franoise S. Lucas, Frederic J. Veyrier, Emmanuelle Cambau, Heberte Accrombessi, Regis Moilleron, Marcel A. Behr, Laurent Moulin
Review
Infectious Diseases
E. Cambau, M. Drancourt
CLINICAL MICROBIOLOGY AND INFECTION
(2014)
Article
Infectious Diseases
Cecile Pautas, Emilie Sbidian, Yosr Hicheri, Sylvie Bastuji-Garin, Stephane Bretagne, Celine Corbel, Laetitia Gregoire, Sebastien Maury, Lilia Merabet, Catherine Cordonnier, Emmanuelle Cambau
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2013)
Article
Infectious Diseases
G. Marcade, J-B. Micol, H. Jacquier, L. Raskine, J-L. Donay, S. Nicolas-Viaud, M. Rouveau, P. Ribaud, H. Dombret, R. Leclercq, E. Cambau
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2014)
Article
Infectious Diseases
H. Jacquier, G. Marcade, E. Raffoux, H. Dombret, P. L. Woerther, J. L. Donay, G. Arlet, E. Cambau
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2013)
Article
Microbiology
Christelle Jost, Beatrice Bercot, Herve Jacquier, Laurent Raskine, Emmanuel Barranger, Genevieve Mouchnino, Emmanuelle Cambau
JOURNAL OF CLINICAL MICROBIOLOGY
(2014)
Article
Immunology
Isabelle Lerat, Emmanuelle Cambau, Romain Roth Dit Bettoni, Jean-Louis Gaillard, Vincent Jarlier, Chantal Truffot, Nicolas Veziris
JOURNAL OF INFECTIOUS DISEASES
(2014)
Article
Microbiology
F. Mougari, H. Jacquier, B. Bercot, D. Hannouche, R. Nizard, E. Cambau, F. Zadegan
JOURNAL OF MEDICAL MICROBIOLOGY
(2013)
Letter
Infectious Diseases
Guy La Ruche, Patrice Sednaoui, Beatrice Bercot, Emmanuelle Cambau, Caroline Semaille
LANCET INFECTIOUS DISEASES
(2014)
Article
Infectious Diseases
G. Gavazzi, E. Delerce, E. Cambau, P. Francois, B. Corroyer, B. de Wazieres, B. Fougere, M. Paccalin, J. Gaillat
MEDECINE ET MALADIES INFECTIEUSES
(2013)
Article
Multidisciplinary Sciences
Thomas Guillard, Antoine Grillon, Christophe de Champs, Celine Cartier, Janick Madoux, Beatrice Bercot, Anne-Laure Lebreil, Alain Lozniewski, Jacques Riahi, Veronique Vernet-Garnier, Emmanuelle Cambau
Article
Public, Environmental & Occupational Health
Helene B. Faury, Zeina Awad, Sarah Jolivet, Killian Le Neindre, Jeanne Couturier, Alexandre Godmer, Raphael Colle, Laura I. Levi, Emmanuelle Cambau, Frederic Barbut
Summary: We present a case of healthcare-associated bloodstream infection caused by Mycobacterium fortuitum. Whole-genome sequencing revealed the presence of the same strain in the shared shower water in the ward. Nontuberculous mycobacteria frequently contaminate hospital water networks, necessitating preventive measures to reduce the exposure risk for immunocompromised patients.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)