Article
Public, Environmental & Occupational Health
Yu-Chung Chuang, Jann-Tay Wang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Yee-Chun Chen, Shan-Chwen Chang
Summary: Combining daptomycin with beta-lactam for the treatment of vancomycin-resistant Enterococcus (VRE) bacteremia significantly improves the composite clinical success rate. This approach is particularly effective when high-dose daptomycin is used and VRE shows a high minimum inhibitory concentration (MIC) for daptomycin.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Tai-Chung Tseng, Yu-Chung Chuang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang
Summary: In this study, combination therapy with high-dose daptomycin and fosfomycin was found to improve the survival rate of patients with vancomycin-resistant enterococcus bloodstream infection compared to daptomycin monotherapy. The survival benefit was most pronounced for patients with fosfomycin MIC ≤64 mg/L and a low Pitt bacteremia score.
INFECTIOUS DISEASES AND THERAPY
(2023)
Review
Infectious Diseases
Chienhsiu Huang, Ihung Chen, Lichen Lin
Summary: Combination therapy with daptomycin plus ceftaroline may reduce mortality in patients with methicillin-resistant Staphylococcus aureus bacteremia. The combination therapy group had similar in-hospital mortality, duration of bacteremia, and adverse event rate compared to the monotherapy group, but had lower bacteremia recurrence.
Article
Chemistry, Medicinal
Jiepeng Tong, Yiheng Jiang, Hao Xu, Xuehang Jin, Li Zhang, Shuaibing Ying, Wei Yu, Yunqing Qiu
Summary: The emergence of vancomycin-resistant Enterococci (VRE) is limiting treatment options for infections. This study investigated the resistance mechanism and evaluated the effects of different antibiotics alone or in combination against VRE isolates. The results suggest that FM combined with DAP could be a potential therapeutic option for VRE infections.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Microbiology
Nagendra N. Mishra, Wessam Abdelhady, Ahmed M. Elsayed, Christian Lapitan, Richard A. Proctor, Michael J. Rybak, Jose M. Miro, Arnold S. Bayer
Summary: The Streptococcus mitis-oralis subgroup is the most common cause of infective endocarditis worldwide, and is frequently resistant to standard beta-lactam drugs. The combination of daptomycin and ceftriaxone has shown effectiveness in clearing the bacteria and preventing the development of resistance. Therefore, in the treatment of serious S. mitis-oralis infections, especially those with intrinsic beta-lactam resistance, combination therapy with daptomycin and ceftriaxone may be warranted.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Environmental Sciences
Mei Huang, Xiaopeng Chen, A. Allan Degen, Ruiying Guo, Tao Zhang, Binyu Luo, Haiyan Li, Jingxue Zhao, Zhanhuan Shang
Summary: The impact of fertilizers on carbon balance in grassland restoration is uncertain and requires further research. In an experiment conducted in an alpine meadow on the Tibetan Plateau, the addition of carbon and/or nitrogen stimulated soil respiration, with nitrogen having a greater effect. Therefore, the application of fertilizer in restoring degraded grassland should be re-evaluated.
ENVIRONMENTAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Xiaonan Xu, Ni Lu, Pan Song, Mingzhen Zhou, Yuanxiao Li, Zirui Wang, Xin Gao
Summary: This study evaluated the efficacy and safety of different treatments for methicillin-resistant Staphylococcus aureus (MRSA). The results showed that vancomycin or daptomycin combined with antistaphylococcal beta-lactam had slightly better efficacy than vancomycin or daptomycin alone, but with slightly higher adverse events. Other treatments, such as antistaphylococcal beta-lactam and trimethoprim-sulfamethoxazole, did not show significant advantages compared to vancomycin or daptomycin treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Silvia Corcione, Tommaso Lupia, Carlo Pallotto, Daniele Roberto Giacobbe, Ilaria De Benedetto, Giacomo Stroffolini, Simone Mornese Pinna, Carlo Tascini, Matteo Bassetti, Francesco Giuseppe De Rosa
Summary: This national survey provides insights into the clinical prescribing habits of daptomycin use in infective endocarditis (IE) and explores the potential role of combination therapy with beta-lactams.
Article
Plant Sciences
Luigi Schillaci, Nevena Djakovic, Ingeborg Lang
Summary: As pollution in the environment worsens, it becomes crucial to accurately determine metal toxicity in plants. Mosses are commonly used as biomonitors, but different species may have varying reactions to metals. This study examined the effects of CuCl2, MnCl2, FeCl2, and Sb-acetate individually and in combinations on two moss species, and found that metal combinations were generally more toxic than individual metals, especially when Cu was present.
Review
Infectious Diseases
Yi-Hu Yi, Jiang-Lin Wang, Wen-Jun Yin, Wei-Hua Xu
Summary: The addition of a beta-lactam to vancomycin or daptomycin for the treatment of MRSA bloodstream infections did not improve survival rates, but did reduce the duration of bacteremia and risk of recurrence. Additional consideration of both the harms and benefits is necessary for the routine management of MRSA-related bacteremia.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Dong-Chan Eun, Kyung-Soo Suk, Hak-Sun Kim, Ji-Won Kwon, Seong-Hwan Moon, Yong-Ho Lee, Byung-Ho Lee
Summary: This study compares the effects of vancomycin powder application and taurolidine irrigation on preventing surgical site infection. Taurolidine irrigation shows a lower infection rate and may be a good substitute for vancomycin powder application.
Article
Microbiology
Chengyi Li, Enrique Valencia, Yan Shi, Guiyao Zhou, Xilai Li
Summary: This study examined the effects of nitrogen addition on soil nitrogen-fixing bacteria (NFB) diversity in degraded alpine meadow soils on the Tibetan Plateau. Results showed significant differences in dominant bacterial species between different slopes. The diversity indices of NFB did not differ significantly between slopes, except for the Shannon index. Interestingly, N addition had no effect on NFB diversity or the abundance of dominant bacteria, but it did lead to significant changes in some low-abundance NFB. The composition and diversity of NFB were significantly correlated with slope and soil physicochemical properties.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Xin Zhou, XiaoShuang Niu, PeiYao Liu, Dan Ou, Yi Zhu, XiaoShen Wang
Summary: The study evaluated the efficacy of ICI alone or combined with chemotherapy in RAU-NPC patients who progressed after second line chemotherapy. The results showed promising antitumor activity with low toxicity profile for both treatment approaches. However, chemotherapy plus ICI did not improve complete response or partial response compared to ICI alone.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agronomy
Renan J. Parecido, Rogerio P. Soratto, Marcos J. Perdona, Fernando V. C. Guidorizzi, Guilherme G. Gomes, Rodrigo A. Paula, Harun Gitari
Summary: Soil acidity and low concentrations of exchangeable Ca and Mg limit Arabica coffee yield in Brazil. The study found that sole application of limestone significantly increased coffee yield and economic returns, while phosphogypsum application positively affected Ca and SO4-S concentrations.
Article
Forestry
Xuemin Ye, Wensheng Bu, Xiaofei Hu, Fangchao Wang, Rongxi Sun, Pengcheng He, Xingyun Liang, Fusheng Chen
Summary: The availability of nitrogen and phosphorus has a significant impact on forest productivity and function, but predicting tree responses is challenging due to trait plasticity among different size classes and tree species. A field experiment in an evergreen broadleaved forest showed that phosphorus addition increased the relative growth rate of small trees. However, nitrogen and nitrogen-phosphorus combination treatments did not affect tree growth rate. Small trees exhibited greater trait plasticity in response to phosphorus addition, while large trees did not show any changes in functional traits. The results suggest that small subtropical trees have a higher capacity to respond to nutrient alterations and may potentially affect species abundance in the future.
FOREST ECOLOGY AND MANAGEMENT
(2023)