Article
Microbiology
Nadine Rouphael, Patricia Winokur, Michael C. Keefer, Jessica Traenkner, Ana Drobeniuc, Yohei Doi, Sonal Munsiff, Vance G. Fowler, Scott Evans, Randolph E. Oler, Bonifride Tuyishimire, Marina Lee, Varduhi Ghazaryan, Henry F. Chambers
Summary: Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.
Article
Immunology
Michael W. Dunne, Steven Aronin, Anita F. Das, Karthik Akinapelli, Jeanne Breen, Michael T. Zelasky, Sailaja Puttagunta
Summary: This study compared the clinical and microbiological responses of different treatment regimens in patients with complicated urinary tract infections, and the results showed that sulopenem was not superior to the comparator regimen.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Pharmacology & Pharmacy
Dehong Cao, Yinzhi Shen, Yin Huang, Bo Chen, Zeyu Chen, Jianzhong Ai, Liangren Liu, Lu Yang, Qiang Wei
Summary: Systematic review and meta-analysis showed that levofloxacin and ciprofloxacin have similar efficacy for the treatment of urinary tract infections, and both drugs are safe for clinical use.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Masayuki Maeda, Takeshi Hasegawa, Hisashi Noma, Erika Ota
Summary: This systematic review and meta-analysis aims to explore and compare the clinical outcomes of complicated urinary tract infections caused by antimicrobial-resistant uropathogens treated with carbapenem and non-carbapenem antibiotics. The study will search and assess relevant articles published until December 2022, and estimate the treatment effects using the random-effects model.
Review
Infectious Diseases
Yveline Ansaldi, Begona Martinez de Tejada Weber
Summary: Urinary tract infections (UTIs) during pregnancy can have significant consequences for both the mother and the baby. Treating asymptomatic bacteriuria (ASB) can reduce the risk of low birth weight and preterm birth. Further research is needed to understand the complications of ASB and to explore preventive measures.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Immunology
Jonathan Josephs-Spaulding, Thoger Jensen Krogh, Hannah Clara Rettig, Mark Lyng, Mariam Chkonia, Silvio Waschina, Simon Graspeuntner, Jan Rupp, Jakob Moller-Jensen, Christoph Kaleta
Summary: This article discusses the ecological interactions of human urogenital microbial communities, the mechanism of imbalance between microbial ecology and host physiology. A greater understanding of environmental mechanisms and microbial ecology is needed for the treatment and management of UTIs. The use of next generation and systems level methods is recommended to elucidate the systemic consequences of rUTIs.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Utsav Mondal, Stalin Viswanathan, Sreerag Sreenivasan Kodakkattil
Summary: This study aimed to investigate the use and complications of percutaneous nephrostomy (PCN) in patients with urinary tract infections. The results showed that PCN was a safe and effective treatment for patients with infectious diseases such as pyelonephritis, renal abscess, perinephric abscess, and genitourinary tuberculosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Jun Kamei, Shingo Yamamoto
Summary: Diabetes patients are at higher risk for urinary tract infections, with emphysematous pyelonephritis being a life-threatening complication. Treatment for UTI in diabetic patients is similar to non-diabetic patients, and routine screening and treatment of asymptomatic bacteriuria is not recommended. Abdominal computed tomography is useful for diagnosis of emphysematous pyelonephritis, while initial management involves medical treatment and drainage, with nephrectomy reserved for non-responders. Antibiotics and glucose control are effective treatments for emphysematous cystitis, while SGLT2 inhibitors may increase genital tract infections without affecting UTIs.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Review
Medicine, General & Internal
Mariela Corrales, Elizabeth Corrales-Acosta, Juan Guillermo Corrales-Riveros
Summary: Urinary tract infection (UTI) is a common issue in pregnant women, and proper antibiotic selection is crucial for the safety of both mother and fetus. Multiple international guidelines provide recommendations for UTI treatment during pregnancy, with some variations but overall consensus on key points regarding antibiotic use.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Hanna P. Wallin, Mika Gissler, Paivi E. Korhonen, Mikael O. Ekblad
Summary: This study found a correlation between maternal smoking and an increased prevalence of UTIs during pregnancy. However, this association was attenuated in the pregnancy-pair analysis. This suggests that the association between maternal smoking during pregnancy and adverse maternal health effects might be more complex than previously thought.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Infectious Diseases
Niels Frimodt-Moller, Lars Bjerrum
Summary: Understanding the usual benign course of UTIs can help reduce antibiotic treatment in many cases, e.g. starting treatment by pain relief and awaiting the course of infection without antibiotics. Better rapid tests in primary care are urgently needed to enforce such policies.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Microbiology
David Melnick, Angela K. Talley, Vipul K. Gupta, Ian A. Critchley, Paul B. Eckburg, Kamal A. Hamed, Nivedita Bhatt, Gary Moore, Daren Austin, Christopher M. Rubino, Sujata M. Bhavnani, Paul G. Ambrose
Summary: The clinical relevance of bacteriuria after antibiotic treatment of complicated urinary tract infections is controversial. This study evaluated the impact of urine pharmacokinetics on the timing of recurrent bacteriuria in a clinical trial comparing oral tebipenem pivoxil hydrobromide and intravenous ertapenem. The prolonged urinary clearance and dwell time of ertapenem were associated with a temporal difference in the repopulation of bladder urine with bacteria following treatment, potentially confounding efficacy assessment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Akahito Sako, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Hidekatsu Yanai, Yoshiaki Gu, Norio Ohmagari
Summary: This study used a nationwide Japanese database to investigate the incidence of hospitalization due to urinary tract infections, revealing that UTI poses a significant clinical and economic burden in Japan.
BMC INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Candida Diaz-Brochero, Martha Carolina Valderrama-Rios, Laura Cristina Nocua-Baez, Jorge Alberto Cortes
Summary: First-generation cephalosporins could be a potential therapy for community-acquired complicated upper UTI in adults requiring hospital care, although further comparative studies are needed to evaluate their benefits and harms due to limitations in the existing evidence.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Emergency Medicine
Navya Maddali, Amanda Cantin, Sanjana Koshy, Erick Eiting, Marianna Fedorenko
Summary: This study compared and investigated the antimicrobial prescribing patterns for UTIs in different clinical settings and found that the FQ prescribing rate was low, with room for improvement in treatment duration and antimicrobial choice.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)