期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 8, 页码 3528-3533出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00178-09
关键词
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资金
- European Commission
- Ricerca Corrente INMI 2007
- [RUH134]
- [RUH875]
- [RYC 52763/97]
Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla(OXA-24) was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.
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