Article
Clinical Neurology
Xiang Wang, Jinxiu Chen, Jing Gong, Ying Wu, Xiang-hao Liu
Summary: This case presents a rare occurrence of progressive multifocal leukoencephalopathy (PML) caused by JC virus infection in a previously healthy and immunocompetent patient. The patient showed disease stabilization after receiving a combination treatment, which may contribute to our understanding of virus infections during the coronavirus epidemic.
Article
Pharmacology & Pharmacy
Zhong Li, Jimin Xu, Yuekun Lang, Xiangmeng Wu, Saiyang Hu, Subodh Kumar Samrat, Anil M. Tharappel, Lili Kuo, David Butler, Yongcheng Song, Qing-Yu Zhang, Jia Zhou, Hongmin Li
Summary: Erythrosin B is an effective antiviral against Zika virus both in vitro and in vivo, and its derivatives are non-toxic to human cells.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Dario Silva, Marcio V. C. Lopes, Zeljko Petrovski, Miguel M. Santos, Jussevania P. Santos, Sueli F. Yamada-Ogatta, Marcelle L. F. Bispo, Marcus V. N. de Souza, Ana Rita C. Duarte, Maria C. S. Lourenco, Raoni Schroeder B. Goncalves, Luis C. Branco
Summary: The urgent need for novel pharmaceutical tools to combat tuberculosis is highlighted by the rapid development of resistant strains of Mycobacterium tuberculosis. In this study, a repurposed antimalarial drug, mefloquine, was combined with organic anions as chemical adjuvants to create novel formulations. These formulations exhibited improved water solubility, permeability, and antimicrobial activity against Mycobacterium tuberculosis.
Article
Infectious Diseases
Yanmin Hu, Anthony Coates
Summary: The combination of mefloquine and colistin showed synergistic activity against multidrug-resistant Enterobacterales in vitro and in vivo, suggesting its potential for rejuvenating the activity of colistin.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Immunology
Jun Zhao, Lvjie Xu, Yiming Bai, Chao Wang, Pengfei Guo, Zhe Wang, Guanhua Du, Ailin Liu
Summary: Salmeterol, a candidate compound with anti-IAV activity, was found to inhibit the activity of three IAV strains in vitro, improve the survival state of infected mice, and alleviate inflammatory symptoms. This study confirms the anti-IAV activity of salmeterol and provides a research foundation for its new indication and the discovery of new drugs against IAV.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Fisheries
Zhiqi Zhang, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan
Summary: This study manufactured abundant RGNNV VLPs and developed three monoclonal antibodies that can accurately detect the capsid protein of RGNNV and show potential in detection and tracking of the virus. Two of the antibodies also possess some neutralizing capacity against RGNNV infection.
Article
Chemistry, Medicinal
A. Dassonville-Klimpt, J. Schneider, C. Damiani, C. Tisnerat, A. Cohen, N. Azas, M. Marchivie, J. Guillon, C. Mullie, P. Agnamey, Anne Totet, J. Dormoi, N. Taudon, B. Pradines, P. Sonnet
Summary: This study designed, synthesized, and evaluated five new series of aminoalcohol quinolines against Pf3D7 and PfW2 strains in vitro. Among the compounds, fourteen showed promising activity with IC50 values below or near 50.0 nM and high selectivity index. Compound 17b exhibited potent antimalarial activity with IC50 values of 14.9 nM and 11.0 nM against Pf3D7 and PfW2, respectively, and a high selectivity index. Further experiments and in vivo studies are needed to confirm its safety and efficacy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Microbiology
Silvia Scattolini, Daniela D'Angelantonio, Arianna Boni, Iolanda Mangone, Maurilia Marcacci, Noemi Battistelli, Krizia D'Agostino, Francesco Pomilio, Cesare Camma, Giacomo Migliorati, Giuseppe Aprea
Summary: Listeria monocytogenes is a pathogenic bacterium responsible for listeriosis, which can be transmitted through contaminated ready-to-eat foods. Phages like phi IZSAM-1 have shown potential as biodecontaminants for drug-resistant Listeria monocytogenes strains, demonstrating effective control in vitro experiments. This study highlights the importance of phage isolation from the same environments as the target pathogens for successful biocontrol applications in food production.
Article
Virology
Hailin Tang, Yang Liu, Ruiwen Ren, Yan Liu, Yanhua He, Zhongtian Qi, Haoran Peng, Ping Zhao
Summary: This study identified four compounds from approved drugs that can effectively inhibit WNV infection and also demonstrated broad-spectrum antiviral activity. These compounds may be promising therapeutics for WNV infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Gideon D. Badenhorst, Christina Kannigadu, Janine Aucamp, David D. N'Da
Summary: Leishmaniasis is a neglected tropical disease, and new drugs are needed to overcome the limitations of current treatments. This study synthesized a series of nifuroxazide analogues and identified compounds 1l, 2c, and 2d as potential candidates with antileishmanial activity.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Qianran Wang, Ruiyuan Cao, Liushuai Li, Jia Liu, Jingjing Yang, Wei Li, Linjie Yan, Yanming Wang, Yunzheng Yan, Jiang Li, Fei Deng, Yiwu Zhou, Manli Wang, Wu Zhong, Zhihong Hu
Summary: This study evaluated the anti-CCHFV efficacy of several nucleoside analogs and identified a novel compound, H44, as a promising drug candidate for the treatment of CCHFV infection in vivo. The findings suggest that T-705, H44, and EIDD-1931 have inhibitory effects on CCHFV infection, with T-705 and H44 providing complete protection in mice models.
ANTIVIRAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Romain Marlin, Delphine Desjardins, Vanessa Contreras, Guillaume Lingas, Caroline Solas, Pierre Roques, Thibaut Naninck, Quentin Pascal, Sylvie Behillil, Pauline Maisonnasse, Julien Lemaitre, Nidhal Kahlaoui, Benoit Delache, Andres Pizzorno, Antoine Nougairede, Camille Ludot, Olivier Terrier, Nathalie Dereuddre-Bosquet, Francis Relouzat, Catherine Chapon, Raphael Ho Tsong Fang, Sylvie van der Werf, Manuel Rosa Calatrava, Denis Malvy, Xavier de Lamballerie, Jeremie Guedj, Roger Le Grand
Summary: Repurposed antiviral drugs are valuable resources for outbreak defense, but rigorous evaluation in large animal models is crucial for successful clinical implementation. This study evaluates the antiviral activity of favipiravir against Zika virus and SARS-CoV-2 in cynomolgus macaques, highlighting its potential for clinical investigations against Zika virus but advising against its use for SARS-CoV-2 infection.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Sumin Son, Soo Bin Ahn, Geonyeong Kim, Yejin Jang, Chunkyu Ko, Meehyein Kim, Sang Jick Kim
Summary: Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus threaten public health. Broadly neutralizing antibodies (bnAbs) targeting the antigenic surface glycoprotein hemagglutinin (HA) protect against various subtypes of influenza A virus. Two human monoclonal antibodies (mAbs), G1 and G2, were identified in this study, which target HA proteins of H1N1 and H3N2 subtypes, respectively. In cell culture-based assays, G1 and G2 efficiently suppressed infection of H1N1 and H3N2 subtypes. Mode-of-action studies showed that G1 blocked membrane fusion while G2 inhibited viral attachment to host cells. Both antibodies also elicited antibody-dependent cellular cytotoxicity (ADCC) activities. In mouse challenge models, single-shot administration of G1 and G2 antibodies completely protected mice from viral infections. The newly identified bnAbs, G1 and G2, provide insight into the development of broad-spectrum antivirals against future pandemic influenza A viruses.
ANTIVIRAL RESEARCH
(2023)
Review
Oncology
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
Summary: JC polyomavirus (JCPyV) belongs to the human polyomavirus family and can enter the body through various routes. It can persist in lymphoid and renal tissues and is associated with the development of various cancers by affecting cell signaling pathways. Understanding the role of JCPyV in cancer is important for early prevention, diagnosis, and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
You Zhi Nicholas Cheang, Heng Rong Donald Ting, Hui Qi Vanessa Koh, Sylvie Alonso
Summary: Research indicates that metformin has a poor anti-DENV activity in vitro in one cell line, associated with AMPK activation. However, it shows pro-DENV activity in another cell line, suggesting AMPK-independent effects. Another compound, 991, a direct AMPK activator, demonstrated reduced viral titers against all four serotypes across both cell lines.
ANTIVIRAL RESEARCH
(2021)