期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 11, 页码 4930-4933出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00900-09
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资金
- Ministerio de Educacion y Ciencia of Spain
- Instituto de Salud Carlos III [REIPI C03/14, RD06/0008, SAF2006-8154]
The mechanisms responsible for the increasing prevalence of colistin-only-sensitive (COS) Pseudomonas aeruginosa isolates in a Spanish hospital were investigated. Pulsed-field gel electrophoresis revealed that 24 (50%) of the studied isolates belonged to the same clone, identified as the internationally spread sequence type 235 (ST235) through multilocus sequence typing. In addition to several mutational resistance mechanisms, an integron containing seven resistance determinants was detected. Remarkably, the extended-spectrum beta-lactamase GES-1 and its Gly170Ser carbapenem-hydrolyzing derivative GES-5 were first documented to be encoded in a single integron. This work is the first to describe GES enzymes in Spain and adds them to the growing list of beta-lactamases of concern (PER, VIM, and OXA) detected in ST235 clone isolates.
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