期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 8, 页码 3565-3568出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00102-09
关键词
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资金
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health, Department of Health and Human Services [HHSN266200500042C, U19 AI060598]
- NHMRC Senior Research Fellowship [543105]
Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV). Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.
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