期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 53, 期 5, 页码 2145-2148出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01163-08
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资金
- Sanofi-Aventis, France
The combination of levofloxacin and rifampin has been recommended for the treatment of staphylococcal prosthetic infection. In a rabbit model of prosthetic knee infection due to a susceptible clinical strain of Staphylococcus aureus, the combination of levofloxacin and rifampin was bactericidal, significantly reduced bacterial titers in bone compared with levels for rifampin and controls (P < 0.05), sterilized 6 of 12 animals, and prevented the selection of resistant mutants that was observed with rifampin alone, validating clinical recommendations.
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