期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 52, 期 11, 页码 4145-4148出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00959-08
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资金
- NIAID NIH HHS [AI069397, R01 AI069397] Funding Source: Medline
Pyrosequencing was compared to Sanger dideoxy sequencing to detect mutations in FKS1 responsible for reduced echinocandin susceptibility in Candida albicans. These methods were in complete agreement for 10 of 12 clinical isolates with elevated echinocandin MICs, supporting the potential feasibility of pyrosequencing to detect mutations within diploid fungi.
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