Review
Oncology
Azaj Ahmed, Anas Shamsi, Taj Mohammad, Gulam Mustafa Hasan, Asimul Islam, Md. Imtaiyaz Hassan
Summary: This article provides a detailed analysis of Aurora B kinase, emphasizing its importance in the cell cycle, particularly its regulation during mitosis and its impact on cancer progression. The study also highlights the use of small-molecule inhibitors in controlling tumor proliferation and provides insights into their mechanisms of action.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jenny F. Nathans, James A. Cornwell, Marwa M. Afifi, Debasish Paul, Steven D. Cappell
Summary: The study reveals that the G(1)-S checkpoint does not effectively prevent cells with damaged DNA from entering S phase and replicating their DNA, leading to different cell fate outcomes. Cells triggering the DNA damage checkpoint in G(1) phase route back to quiescence, and most damaged cells actually fail to arrest and proceed through the G(1)-S transition.
Article
Multidisciplinary Sciences
Marco D'Ario, Rafael Tavares, Katharina Schiessl, Benedicte Desvoyes, Crisanto Gutierrez, Martin Howard, Robert Sablowski
Summary: The study reveals that cell size variability in the Arabidopsis shoot stem cell niche is corrected by adjusting the growth period before DNA synthesis. KRP4 and FBL17 proteins play key roles in removing excess cell cycle regulators, ensuring daughter cells are born with comparable amounts of KRP4. This suggests a potential mechanism where a cell cycle regulator associated with mitotic chromosomes can read DNA content as a cell size-independent scale.
Article
Biochemistry & Molecular Biology
Aneta Grabarska, Jarogniew J. Luszczki, Kinga Gawel, Wirginia Kukula-Koch, Malgorzata Juszczak, Adrianna Slawinska-Brych, Grzegorz Adamczuk, Magdalena Dmoszynska-Graniczka, Nataliia Kosheva, Wojciech Rzeski, Andrzej Stepulak
Summary: The study found that magnoflorine has anticancer effects against gastric cancer cells by inhibiting proliferation and inducing apoptosis. Combination treatment with docetaxel produced additional pharmacological interaction. Moreover, there was no observed toxicity of magnoflorine in a zebrafish model. These findings provide a foundation for the potential therapeutic use of magnoflorine in gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Boris Bogdanow, Quang Vinh Phan, Luder Wiebusch
Summary: Cytomegaloviruses induce significant changes in cell cycle regulation to enable replication of their DNA genomes. They establish a unique cell cycle arrest at the G(1)/S transition, while activating S phase-specific gene expression and nucleotide metabolism. Despite similarities in cell cycle regulation between human and murine CMVs, there are considerable differences in viral cell cycle effectors and mechanisms of action.
Article
Biochemistry & Molecular Biology
Hao Zhang, Jiayi Qian, Ming Jin, Li Fan, SongJie Fan, Hong Pan, Yang Li, Ningning Wang, Baiyu Jian
Summary: In this study, the anti-gastric cancer activity of Jolkinolide B (JB) isolated from Euphorbia fischeriana Steud was investigated. JB was found to inhibit the proliferation of MKN45 cells in vitro and suppress MKN45 xenograft tumor growth in vivo. The mechanism of action involved DNA damage and cell cycle arrest, as well as induction of apoptosis via the mitochondrial pathway.
BIOSCIENCE REPORTS
(2022)
Article
Endocrinology & Metabolism
Mengxue Jiang, Zhijian Kuang, Yaohui He, Yin Cao, Tingyan Yu, Jidong Cheng, Wen Liu, Wei Wang
Summary: This study reveals that SNAPIN plays a crucial role in regulating insulin secretion and beta cell proliferation, with its expression influenced by age and diabetes. The function of SNAPIN is achieved through its impact on cell cycle regulation, suggesting it might be a potential pharmacotherapeutic target for diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Michela Roberto, Andrea Botticelli, Martina Panebianco, Anna Maria Aschelter, Alain Gelibter, Chiara Ciccarese, Mauro Minelli, Marianna Nuti, Daniele Santini, Andrea Laghi, Silverio Tomao, Paolo Marchetti
Summary: In recent years, the therapeutic landscape for metastatic renal cell cancer has expanded with the introduction of various treatment options including molecular targeted agents and immune checkpoint inhibitors. Combining these treatments has shown to improve radiological response, prolong progression-free survival, and overall survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin
Summary: PTBP3 is overexpressed in LUSC tissues and its high expression is significantly correlated with poor prognosis. PTBP3 knockdown results in decreased cell proliferation rate. Bioinformatics analysis reveals that PTBP3 is involved in cell cycle regulation in LUSC.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Dongli Guo, Jing Jin, Jianghui Liu, Xiaoping Dong, Daojuan Li, Yutong He
Summary: Silencing miR-29b in ESCC cells can increase BTG2 expression and decrease intracellular cyclin D1 levels, leading to cell cycle arrest and accumulation in the G0/G1 phase, which reduces sensitivity to radiotherapy.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Review
Biochemistry & Molecular Biology
Dario Rizzotto, Lukas Englmaier, Andreas Villunger
Summary: P53 is a critical tumor suppressor that prevents oncogenesis through multiple pathways, leading to cell cycle arrest and cell death. Its function is cell-type and stimulus-specific, ultimately imposing a barrier to cellular transformation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Junneng Zhang, Huanzong Zhang, Yinghui Wang, Qingshui Wang
Summary: The study revealed that the MCM2-7 genes are overexpressed in ccRCC patients and associated with poor prognosis. MCM2-7 influences the progression of ccRCC by regulating the cell cycle. A two-gene risk score model including MCM4 and MCM6 can predict overall survival of ccRCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Deshuai Ren, Xiaoyu Zhuang, Yanxin Lv, Yun Zhang, Jiazhi Xu, Fengquan Gao, Dagang Chen, Yu Wang
Summary: This study found that FAM84B is highly expressed in glioma tissues and inhibits the proliferation of glioma cells through regulating the cell cycle pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniella A. Gomes, Anna M. Joubert, Michelle H. Visagie
Summary: The study found that papaverine (PPV) exhibits dose- and time-dependent antiproliferative activity on MDA-MB-231, A549, and DU145 cell lines, while also increasing cellular protrusions and oxidative stress. Exposure to PPV resulted in alterations in cell cycle progression, with more cells entering the sub-G(1) phase and endoreduplication.
Article
Multidisciplinary Sciences
Simone Di Franco, Paola Bianca, Davide Stefano Sardina, Alice Turdo, Miriam Gaggianesi, Veronica Veschi, Annalisa Nicotra, Laura Rosa Mangiapane, Melania Lo Iacono, Irene Pillitteri, Sander van Hooff, Federica Martorana, Gianmarco Motta, Eliana Gulotta, Vincenzo Luca Lentini, Emanuele Martorana, Micol Eleonora Fiori, Salvatore Vieni, Maria Rita Bongiorno, Giorgio Giannone, Dario Giuffrida, Lorenzo Memeo, Lorenzo Colarossi, Marzia Mare, Paolo Vigneri, Matilde Todaro, Ruggero De Maria, Jan Paul Medema, Giorgio Stassi
Summary: Obesity is identified as a major risk factor for cancer related deaths. Visceral adipose-derived factors activate STAT3, inhibiting miR-200a and enhancing ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Abdulazeez Salawu, Aaron R. Hansen, Anna Spreafico, Esmail Al-Ezzi, Sheila Webster, Philippe L. Bedard, Jeffrey Doi, Lisa Wang, Lillian L. Siu, Albiruni R. Abdul Razak
Summary: Afatinib demonstrated modest activity in tumors with EGFR and ERBB2 aberrations, particularly with clinical benefit seen in salivary gland cancer.
Article
Otorhinolaryngology
Badr Id Said, Laurie Ailles, Christina Karamboulas, Jalna Meens, Shao Hui Huang, Wei Xu, Sareh Keshavarzi, Scott Bratman, B. C. John Cho, Meredith Giuliani, Ezra Hahn, John Kim, Brian O'Sullivan, Jolie Ringash, John Waldron, Anna Spreafico, John R. de Almeida, Douglas B. Chepeha, Jonathan C. Irish, David P. Goldstein, Andrew Hope, Ali Hosni
Summary: Patient-derived xenografts (PDXs) can be used to identify patients with oral cavity squamous cell carcinoma (OSCC) who are at risk for recurrence. This study aimed to develop and validate a prediction score that incorporates PDX engraftment and known risk factors for locoregional failure (LRF) and distant metastases (DM) in OSCC. The prediction score was able to identify patients at high risk and low risk for LRF, DM, and poor survival.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Oncology
Diana Paola Arteaga Ceballos, Zaid Saeed-Kamil, Ian King, Tracy Stockley, Diane Liu, Thiago P. Muniz, Samuel D. Saibil, David Hogg, Anna Spreafico, Marcus O. Butler
Summary: This study identified variations in BRAF test results in turnaround time (TAT). One factor affecting this timeline is transfer time, which can be streamlined by pathology reflex testing. Delays in TAT affect the timing and type of therapeutic intervention, especially in patients with stage IV disease.
JCO ONCOLOGY PRACTICE
(2022)
Article
Otorhinolaryngology
Ghazal Haddad, Katrina Hueniken, Maria Christine Xu, Scott Bratman, John de Almeida, David Goldstein, Shao Hui Huang, Aaron Hansen, Andrew Hope, Anna Spreafico, Wei Xu, Geoffrey Liu
Summary: This study identified distinct patient clusters based on longitudinal symptom severity trajectories in oropharyngeal cancer, which were prognostic of overall survival.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Funda Meric-Bernstam, Randy F. Sweis, Stefan Kasper, Omid Hamid, Shailender Bhatia, Reinhard Dummer, Agostina Stradella, Georgina Long, Anna Spreafico, Toshio Shimizu, Neeltje Steeghs, Jason J. Luke, Sarah M. McWhirter, Thomas Mueller, Nitya Nair, Nancy Lewis, Xinhui Chen, Andrew Bean, Lisa Kattenhorn, Marc Pelletier, Shahneen Sandhu
Summary: This study assessed the safety and tolerability of the combination of MIW815 and spartalizumab in patients with advanced solid tumors or lymphomas. The results showed that the combination therapy had immune activation but limited antitumor activity.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Milad Soleimani, Alexander Somma, Tamer Kaoud, Ria Goyal, Jorge Bustamante, Dennis C. Wylie, Nisha Holay, Agnieszka Looney, Uma Giri, Todd Triplett, Kevin Dalby, Jeanne Kowalski, S. Gail Eckhardt, Carla Van Den Berg
Summary: JNK-IN-8, a covalent JNK inhibitor, suppresses the growth of triple-negative breast cancer (TNBC) by activating TFEB/TFE3 and inducing lysosome biogenesis and autophagy via mTOR inhibition independently of JNK.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
John J. W. Lee, Vijay Kunaratnam, Christina J. H. Kim, Martha Pienkowski, Katrina Hueniken, Axel Sahovaler, Andrew C. L. Lam, Joel C. Davies, Catherine M. Brown, John R. De Almeida, Shao Hui Huang, John N. Waldron, Anna Spreafico, Rayjean J. Hung, Wei Xu, David P. Goldstein, Geoffrey Liu
Summary: Smoking cessation and long-term abstinence are associated with improved overall survival and HNSCC-specific survival in patients with HNSCC. Former smokers have a reduced risk of overall mortality compared with current smokers, especially those who quit smoking more than 10 years before diagnosis. Long-term abstinence is significantly associated with a decreased risk of HNSCC-specific death.
Review
Biochemistry & Molecular Biology
Pavlina Spiliopoulou, Olga Vornicova, Sofia Genta, Anna Spreafico
Summary: Recent advances in treating cutaneous melanoma have significantly improved patient survival rates by refining disease staging, accurately classifying patient risk, and introducing cancer immunotherapy. Immunotherapy, particularly in the form of immune checkpoint inhibition, has played a crucial role in managing both early and late-stage melanoma and has extended its benefits to other types of skin cancers as well. This review summarizes the current role of immunotherapy in melanoma and non-melanoma skin cancers, highlights important immunotherapy-related molecular biomarkers, and discusses future research directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sofia Genta, Katherine Lajkosz, Noelle R. Yee, Pavlina Spiliopoulou, Alya Heirali, Aaron R. Hansen, Lillian L. Siu, Sam Saibil, Lee-Anne Stayner, Maryia Yanekina, Maxwell B. Sauder, Sareh Keshavarzi, Abdulazeez Salawu, Olga Vornicova, Marcus O. Butler, Philippe L. Bedard, Albiruni R. Abdul Razak, Robert Rottapel, Andrzej Chruscinski, Bryan Coburn, Anna Spreafico
Summary: This study used custom autoantigen microarrays to analyze autoantibodies related to immune-related adverse events in patients receiving immune checkpoint inhibitors. The results support the potential role of autoantibodies in the occurrence and development of immune-related adverse events.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Alberto Hernando-Calvo, Eoghan Malone, Daphne Day, Amy Prawira, Ilan Weinreb, S. Y. Cindy Yang, Horace Wong, Angela Rodriguez, Sarah Jennings, Anneli Eliason, Lisa Wang, Anna Spreafico, Lillian L. Siu, Aaron R. Hansen
Summary: This study aimed to evaluate the activity of selinexor in patients with recurrent or metastatic salivary gland tumors. The results showed limited anti-tumor activity of selinexor, although some tumor reduction was observed.
Article
Oncology
Maysa Vilbert, Erica C. Koch, April A. N. Rose, Rob C. Laister, Diana Gray, Valentin Sotov, Susanne Penny, Anna Spreafico, Devanand M. Pinto, Marcus O. Butler, Samuel D. Saibil
Summary: Cutaneous melanoma (CM) patients respond better to immune checkpoint inhibitors (ICI) than mucosal and uveal melanoma patients (MM/UM). Aiming to explore these differences and understand the distinct response to ICI, we evaluated the serum metabolome of advanced CM, MM, and UM patients. Our study revealed a distinct metabolomic profile between the most resistant melanoma subtypes, UM and MM, compared to CM. Alterations within the kynurenine pathway, polyamine metabolism, and sphingolipid metabolic pathway may contribute to the poor response to ICI.
Meeting Abstract
Oncology
Mauricio Fernando Fernando Silva Almeida Ribeiro, Nancy Gregorio, Faiza Somji, Sheena Melwani, Mike Lovas, Alyssa Macedo, Diana Gray, Raviya Singh, Erika Giovannetti, Suheon Lee, Sharon Chong, Alejandro Berlin, Samuel Saibil, Anna Spreafico, David Hogg, Marcus O. Butler
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Seth Kibel, Nathan Kuehne, Mauricio Ribeiro, Thiago Pimentel Muniz, Philip Wong, Anna Spreafico, David Hogg, Sam Saibil, Alexander Sun, David Y. Mak, Diana Gray, Marcus O. Butler
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Enrique Sanz Garcia, Eric Y. Zhao, Zhihui Amy Liu, Kayla Marsh, Albiruni Ryan Abdul Razak, Anna Spreafico, Philippe L. Bedard, Aaron Richard Hansen, Stephanie Lheureux, Dax Torti, Bernard Lam, Trevor John Pugh, Lillian L. Siu
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Enrique Sanz Garcia, Sofia Genta, Xiaoxi Chen, Qiuxiang Ou, Daniel Vilarim Araujo, Albiruni Ryan Abdul Razak, Aaron Richard Hansen, Anna Spreafico, Hua Bao, Xue Wu, Lillian L. Siu, Philippe L. Bedard
JOURNAL OF CLINICAL ONCOLOGY
(2022)