期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 14, 期 3, 页码 418-439出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/18715206113139990317
关键词
Anticancer; cancer; prodrug; small molecule; therapy
资金
- National Basic Research Program of China [2011CB933503]
- Technology Supporting Program of Jiangsu province [BE2009639, BE2012657]
Chemotherapy has been performed to treat metastatic cancers but with varying degrees of success. The optimal potential of chemotherapy has not been achieved yet. Numerous compounds cannot be further developed to produce potent drugs because these compounds exhibit poor druggability. To resolve this issue, researchers developed prodrugs in drug discovery because these drugs can be efficiently used. Many small-molecule prodrugs have been designed and synthesized as anticancer agents for several years, and great progress has been achieved. In this study, recently developed, efficient anticancer prodrugs were reviewed, particularly small molecule prodrugs. Moreover, small molecule anticancer prodrugs were summarized according to different types of chemical structures and properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据