期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 11, 期 7, 页码 687-691出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/187152011796817664
关键词
Anti-tumor; 2-Nitroimidazole; Hypoxic cell radiosensitizer; Bio-reductive prodrug
资金
- Jiangsu National Science Foundation [BK2009239]
At present cancer treatment is still a confusing problem. Great progress has been made in anti-tumor agents since a series of small molecules are approved by FDA as anti-tumor drugs. Nitroimidazoles is a kind of radiosensitizer with multiple bioactivities used in cancer treatment since 1950s. In this review, we focus on the development of nitroimidazoles as radiosensitizer, bio-reductive prodrug and other types of anti-tumor agents for cancer therapy, and the mechanism of acting as anti-tumor agents. Finally, we also discuss the prospect and developmental trend of nitroimidazoles as anti-tumor agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据