Article
Medicine, Research & Experimental
Haoran Xu, Yongjia Tang, Yue Zhao, Fang Wang, Xin Gao, Dawei Deng, Yueqing Gu
Summary: A Tc-99m-labeled probe targeting GPC3 for SPECT imaging in HCC was developed with excellent stability and binding specificity, demonstrating acceptable binding specificity in in vitro cell assays. HepG2 tumors were clearly visualized with high contrast on SPECT/CT imaging, with promising potential for further clinical translation.
MOLECULAR PHARMACEUTICS
(2021)
Article
Oncology
Giuseppe Cabibbo, Maria Reig, Ciro Celsa, Ferran Torres, Salvatore Battaglia, Marco Enea, Giacomo Emanuele Maria Rizzo, Salvatore Petta, Vincenza Calvaruso, Vito Di Marco, Antonio Craxi, Amit G. Singal, Jordi Bruix, Calogero Camma
Summary: A simulation model comparing different first-line immunotherapy and second-line systemic treatment sequences in advanced HCC patients found that ATEZO plus BEVA followed by LENVA or SORA was the most effective sequence. The study suggests that future evidence from clinical trials and real-world studies is needed to validate the benefits of sequential treatment options.
Review
Oncology
Siyu Fu, Jose D. Debes, Andre Boonstra
Summary: Hepatocellular carcinoma (HCC) is a common primary liver malignancy with poor prognosis. Epigenetic modification, specifically DNA methylation, plays a significant role in HCC development by impacting cell differentiation, proliferation, and function. Methylated DNA markers have shown promise as specific biomarkers for early-stage HCC detection, offering higher sensitivity and specificity compared to current surveillance methods. However, the immediate application of these biomarkers is limited by various factors. This review provides a detailed rationale for using methylation biomarkers in HCC detection and summarizes recent studies on methylated DNA markers, emphasizing the importance of the underlying cause of liver disease in cancer mechanisms.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biology
Laith R. Sultan, Mrigendra B. Karmacharya, Stephen J. Hunt, Andrew K. W. Wood, Chandra M. Sehgal
Summary: The study evaluated the use of repeated subsequent AVUS therapy to optimize therapeutic efficacy in treating hepatocellular carcinoma (HCC). Short intervals between subsequent AVUS treatments showed significant improvement in tumor perfusion reduction, while longer intervals resulted in diminished effects. The findings suggest the importance of tumor viability in maximizing the therapeutic effects of targeted tumor vasculature therapies.
Article
Oncology
Bart Vanderborght, Kevin De Muynck, Eva Gijbels, Sander Lefere, Charlotte L. Scott, Martin Guilliams, Alain Beschin, Mathieu Vinken, Xavier Verhelst, Anja Geerts, Hans Van Vlierberghe, Lindsey Devisscher
Summary: Due to the rapid progression of the disease and the lack of curative treatments, hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. While monocyte-derived tumor-associated macrophages are known to contribute to HCC, the role of Kupffer cells (KCs) remains unclear. This study used a mouse model to investigate the effect of KC depletion on HCC initiation and progression, and found that the temporary ablation of resident KCs did not impact HCC pathogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Chemistry, Medicinal
Jianqing Yu, George G. Chen, Paul B. S. Lai
Summary: Hepatocellular carcinoma is a major cause of cancer mortality worldwide, with current treatments showing unsatisfactory outcomes. The HGF/c-Met axis is considered crucial in regulating liver diseases and promoting HCC, and inhibiting this pathway may lead to the development of new and effective treatments for HCC.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Engineering, Multidisciplinary
Ghassan K. Abou-Alfa, Lin Wu, Augusto Villanueva
Summary: Early detection of hepatocellular carcinoma is crucial for reducing mortality rates, but sensitive biomarkers are still lacking. Research into circulating tumor-derived molecular features, such as circulating tumor DNA and RNA, has potential for noninvasive biomarker candidates in various tumor types.
Review
Oncology
Philippe Rochigneux, Brice Chanez, Bernadette De Rauglaudre, Emmanuel Mitry, Christian Chabannon, Marine Gilabert
Summary: The mortality of hepatocellular carcinoma (HCC) is rapidly increasing worldwide, and immunotherapy involving engineered T cells has shown promising results in clinical trials for combating liver cancer.
Review
Chemistry, Analytical
Xiaogang Lin, Ke Wang, Chunfeng Luo, Mengjie Yang, Jayne Wu
Summary: Hepatocellular carcinoma (HCC) is the main type of liver cancer, which is often diagnosed at an advanced stage. MicroRNAs (miRNAs) have been identified as valuable biomarkers for early HCC detection, but their detection is challenging. In recent years, biosensors have been developed to detect miRNAs in a simple, rapid, highly specific, and sensitive manner. These studies are expected to improve the prognosis and survival status of HCC patients.
Article
Oncology
Yeonjung Ha, Jihye Lim, Young Eun Chon, Mi Na Kim, Joo Ho Lee, Kang Mo Kim, Ju Hyun Shim, Danbi Lee, Seong Gyu Hwang, Seungbong Han, Han Chu Lee
Summary: This study constructed and validated a reliable model for predicting the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) after 5 years of entecavir (ETV) or tenofovir (TFV) therapy. The model, called PPACS, incorporated factors such as age, sex, liver cirrhosis, platelet counts, and prothrombin time. The PPACS model showed good performance in predicting HCC risk after 5 years of ETV/TFV therapy.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Robert A. Scott, Timothy J. S. Cross, Christopher Clarke, Shahid A. Khan, Stephen D. Ryder, James Franklin, Aloysious D. Aravinthan
Summary: This survey aimed to describe the adherence and practices of HCC surveillance among NHS hospitals in the UK. The results showed that most hospitals follow the guideline of biannual surveillance, but there is inconsistency in data recording and quality. Surveillance is mainly performed by non-HPB specialists without standardized reporting. Therefore, even in a free universal healthcare system, the surveillance and management of HCC remain variable.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Gastroenterology & Hepatology
K. Rajender Reddy, Dale McLerran, Tracey Marsh, Neehar Parikh, Lewis R. Roberts, Myron Schwartz, Mindie H. Nguyen, Alex Befeler, Stephanie Page-Lester, Runlong Tang, Sudhir Srivastava, Jo Ann Rinaudo, Ziding Feng, Jorge A. Marrero
Summary: This is the largest prospective and geographically diverse study of a U.S. cohort of patients with cirrhosis, validating known risk factors for HCC.
Article
Biotechnology & Applied Microbiology
Xuqi Peng, Gan Lin, Yun Zeng, Zhao Lei, Gang Liu
Summary: Hepatocellular carcinoma is associated with poor prognosis, but early-stage patients have better survival rates. Mesoporous silica nanoparticles-based imaging agents have emerged as a promising tool for early detection of HCC, offering potential applications in clinical settings despite some challenges to overcome. Multi-modal imaging systems have been developed for enhanced spatial resolution and sensitivity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Devalingam Mahalingam, Leonidas Chelis, Imran Nizamuddin, Sunyoung S. Lee, Stylianos Kakolyris, Glenn Halff, Ken Washburn, Kristopher Attwood, Ibnshamsah Fahad, Julia Grigorieva, Senait Asmellash, Krista Meyer, Carlos Oliveira, Heinrich Roder, Joanna Roder, Renuka Iyer
Summary: This study utilizes a machine learning algorithm along with mass spectral data and AFP values from serum samples to detect HCC with high sensitivity and specificity. The results suggest that this method can improve cancer detection, especially for small lesions.
Article
Medicine, General & Internal
Vichununt Kerdput, Kritsakorn Kanjanapongkul, Arunporn Itharat, Ratchadaporn Pramong, Wouter H. Lamers, Theodorus B. M. Hakvoort, Aldo Jongejan, Wisuit Pradidarcheep
Summary: This study examined the mechanisms of action of Thai herbal plant extract DM in the treatment of hepatocellular carcinoma. The results showed that DM has antioxidant activity and exerts its effects on rat HCC through promoting apoptosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)