Article
Chemistry, Medicinal
Yueqin Zhao, Xu Yang, Jimin Fei, Xianxiang Dong, Yinyuan Wang, Shan Yang, Xiaojiang Hao, Xiao Ding, Yuhan Zhao
Summary: In this study, three new limonoids were isolated from Walsura yunnanensis, and their cytotoxic activity against human cancer cells was evaluated. The compounds showed significant inhibition of cell growth and induced cell cycle arrest and apoptosis.
Article
Biochemistry & Molecular Biology
Jeyce Kelle Ferreira de Andrade, Alexandre Jose da Silva Goes, Vanessa Xavier Barbosa, Mariza Severina de Lima Silva, Mariana Aragao Matos Donato, Christina Alves Peixoto, Gardenia Carmen Gadelha Militao, Teresinha Goncalves da Silva
Summary: Thiosemicarbazones derived from beta-lapachone showed potent cytotoxic effects on leukemia cells, with BV3 being the most selective compound, exhibiting high toxicity to tumor cells and low toxicity to normal cells. These compounds have the potential to be promising candidates for anticancer drugs.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Michael L. Bittner, Rosana Lopes, Jianping Hua, Chao Sima, Aniruddha Datta, Heather Wilson-Robles
Summary: The study demonstrates the effectiveness of Cryptotanshinone (CT) in combating cancer and inducing apoptosis in human and canine cancer cells. Results verified CT's high efficacy in inhibiting cancer cell survival, showing its potential application across different cancer cell lines.
Article
Cell Biology
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang
Summary: The study demonstrated that ginkgetin has an anti-tumor effect on human hepatocellular carcinoma cell lines by inducing apoptosis through affecting the balance between cell proliferation and apoptosis.
Article
Biochemistry & Molecular Biology
Guo-Kai Wang, Yun-Peng Sun, Wen-Fang Jin, Yang Yu, Jian-Yong Zhu, Jin-Song Liu
Summary: Sixteen new limonoids and 18 known limonoids were isolated from Swietenia macrophylla, and their structures were determined. Limonoid 19 exhibited significant cytotoxic effects against A375 cells and induced apoptosis.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Ceccarelli, Laura Marchetti, Milena Rizzo, Aldo Moscardini, Valentina Cappello, Eleonora Da Pozzo, Miriam Romano, Chiara Giacomelli, Paolo Bergese, Claudia Martini
Summary: This study reports a workflow for the extraction and characterization of different types of EVs from adult and embryonic microglia cell lines. The authors found differences in quantity and dispersion between EVs derived from different cell lines. Moreover, EVs derived from one cell line were able to interfere with the proliferation of glioblastoma cells, which correlated with different levels of miRNAs involved in neuroinflammation and tumor progression. These findings fill a research gap in the field of microglia EVs and emphasize the need for better characterization of EVs' features and biological effects.
Article
Oncology
Megha Gautam, Reema Gabrani
Summary: The study found that the combination of naringenin (NAG) and temozolomide (TMZ) enhances the cytotoxic effects on glioblastoma multiforme (GBM) cells, significantly reducing cell migration and single-cell colony formation.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Keying Liu, Biyun Xue, Guiqin Bai, Wentao Zhang
Summary: The study demonstrates that elevated DGKZ expression in cervical cancer tissues and downregulation of DGKZ inhibit cell proliferation, promote apoptosis, and induce cell cycle arrest. Moreover, in a nude mouse model, knockdown of DGKZ suppresses tumor growth. Functional analysis indicates that DGKZ may play a role in cell proliferation and tumor growth through autophagy or mitophagy pathways. PathScan analysis reveals inhibition of PI3K-AKT and TAK1-NF-kappa B signaling pathways in DGKZ-silenced cells.
Article
Oncology
Giada Pontecorvi, Maria Bellenghi, Sabrina Tait, Valentina Tirelli, Paola Matarrese, Gianfranco Mattia, Alessandra Care, Rossella Puglisi
Summary: Gender differences in melanoma incidence and survival have been observed, with women showing better outcomes than men. Sex hormones, specifically estrogen receptors (ERs), may play a key role in these disparities. This study investigated how the ER beta agonist LY500307 affects melanoma cell proliferation, migration, and apoptosis. The results suggest that LY500307 has the potential to reduce melanoma malignancy and could be used in personalized combined therapy.
Article
Chemistry, Multidisciplinary
Mai Hussin Radi, Riham A. A. El-Shiekh, Ali M. M. El-Halawany, Ahmed M. M. Al-Abd, Essam Abdel-Sattar
Summary: This study evaluated the antiproliferative activity of E. grantii aerial parts, and found that the dichloromethane fraction showed promising cytotoxic activity against breast cancer cell lines. Eight compounds were isolated from the active fraction, and euphylbenzoate exhibited the best anticancer activity. These results demonstrate that E. grantii aerial parts contain active compounds with significant antiproliferative potential.
Article
Biochemistry & Molecular Biology
Feng Qin, Cai Yi Wang, Chun-Gu Wang, Yao Chen, Jin-Jun Li, Mei-Shan Li, Yan-Kui Zhu, Sang Kook Lee, Heng-Shan Wang
Summary: Several previously unknown alkaloids were isolated from Zanthoxylum nitidum, a plant with potential medicinal properties. One of these alkaloids showed significant anti-cancer activity by inhibiting proliferation and migration of cancer cells.
Article
Chemistry, Medicinal
Barbara Bednarczyk-Cwynar, Anna Leskow, Izabela Szczuka, Lucjusz Zaprutko, Dorota Diakowska
Summary: This study aimed to synthesize new derivatives of oleanolic acid (OA) and investigate their anti-cancer potential against melanoma cells. Two OA derivatives (3a and 3b) showed significant anti-proliferative and cytotoxic effects on A375 and MeWo melanoma cells at certain concentrations and incubation times. Further studies are needed to explore the proapoptotic and anti-cancer activities of 3a and 3b on other cancer cells. The bromoacetoxyimine derivative (3b) of OA morpholide exhibited the highest effectiveness against the tested cancer cells.
Article
Plant Sciences
Subrata Das, Ashikur Rahaman, Rajat Nath, Anupam Das Talukdar, Deepa Nath, Shamee Bhattacharjee, Deba Prasad Mandal, Manabendra Dutta Choudhury, Dipika Das, Gitishree Das, Jayanta Kumar Patra
Summary: The aquatic plant Ottelia alismoides has been used in traditional medicine for treating various diseases. This study aimed to evaluate the apoptotic potential of its acetone extract and identify the compounds responsible for this effect.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aigul Kh. Valiullina, Ekaterina A. Zmievskaya, Irina A. Ganeeva, Margarita N. Zhuravleva, Ekaterina E. Garanina, Albert A. Rizvanov, Alexey V. Petukhov, Emil R. Bulatov
Summary: In recent years, adoptive cell therapy has gained new applications in the field of oncology, particularly with the development of CAR-T cells for treating malignant B-cell neoplasms. However, the use of CAR-T therapy for solid tumors remains a challenge. This study evaluated the cytotoxicity of 2nd generation CAR-T cells on various solid tumor cell lines and demonstrated a correlation between cytokine secretion and tumor cell confluence. This approach may have potential for assessing CAR-T cell efficacy and cytokine release syndrome risks in solid tumor treatment.
Article
Biotechnology & Applied Microbiology
Yuanhua Lu, Jie Ma, Jian Lin, Yafei Tian, Yongjun Ma, Wei Wang, Jialin Li, Hugang Zhang, Ping Jiao
Summary: A new peptide KK-64 was designed in this study, showing strong cytotoxicity against liver cancer cells. The pcTERT-kk-64 plasmid demonstrated tumor targeting property and significant inhibition of liver cancer cell viability.