Article
Biochemistry & Molecular Biology
Jyoti B. Kaushal, Vinay Shukla, Pushplata Sankhwar, Rajesh K. Jha, Anila Dwivedi
Summary: The study uncovered the crucial role of TAK1 in mediating TGF beta 1-induced responses in endometriotic cells, influencing the activation of the NF kappa B-p65/Smad7 signaling cascade and subsequently affecting cell growth and inflammatory responses.
Article
Immunology
Zhenjie Cao, Xin Yang, Tao Li, Zhiru Liu, Pengfei Li, Yongcan Zhou, Yun Sun
Summary: TroBcl2, an anti-apoptotic regulator, was cloned and its role in apoptosis was investigated in this study. It was found that TroBcl2 was widely distributed in various tissues and its expression was upregulated after LPS stimulation. Functional experiments demonstrated that TroBcl2 inhibits apoptosis by reducing mitochondrial membrane potential loss, decreasing DNA fragmentation, preventing cytochrome c release into the cytoplasm, and reducing caspase 3 and caspase 9 activations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
Article
Gastroenterology & Hepatology
Yue Feng, Haibo Dong, Bo Sun, Yun Hu, Yang Yang, Yimin Jia, Longfei Jia, Xiang Zhong, Ruqian Zhao
Summary: The study revealed the close association between m(6)A methylation, METTL3/METTL14 upregulation, and TGF-beta 1 upregulation in NASH rat liver and LPS-activated KCs. NF-kappa B acts as a transcription factor to transactivate METTL3/METTL14 genes, leading to global RNA m(6)A hypermethylation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Cell Biology
Xiaodong Zou, Hongsheng Ouyang, Feng Lin, Huanyu Zhang, Yang Yang, Daxin Pang, Renzhi Han, Xiaochun Tang
Summary: Mutations in the MYBPC3 gene are a common cause of hypertrophic cardiomyopathy (HCM) and can lead to myocardial fibrosis. This study developed a mutant pig model and found that the mutant MYBPC3 gene caused early-onset myocardial fibrosis. Surprisingly, the MYBPC3 gene was expressed in cardiac fibroblasts as well as NIH3T3 fibroblasts. Disruption of Mybpc3 in NIH3T3 fibroblasts activated the NF-kappa B signaling pathway, leading to upregulation of pro-inflammatory genes including TGF-beta 1. The upregulation of TGF-beta 1 promoted the expression of HIF-1 alpha and glycolysis-related genes, contributing to the activation of cardiac fibroblasts and the development of HCM.
CELL DEATH & DISEASE
(2022)
Review
Pharmacology & Pharmacy
Bilal Zulfiqar, Asim Farooq, Shahzina Kanwal, Kashif Asghar
Summary: Lung cancer is a highly prevalent and deadly disease, often diagnosed at advanced stages. Surgery is not an option at this point, so radiotherapy, chemotherapy, or a combination of both is used. However, these therapies are often ineffective, necessitating the search for alternative preventive approaches. Targeting the tumor microenvironment has proven to be an effective therapy against lung cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Dalia H. El-Kashef, Randa A. Zaghloul
Summary: This study demonstrated that montelukast exerts hepatoprotective effects against CCl4-induced hepatotoxicity through antioxidant, anti-inflammatory, anti-fibrotic, and anti-apoptotic mechanisms.
Article
Environmental Sciences
Jing Tang, Chenjuan Yao, Yingqi Liu, Jiaming Yuan, Li Wu, Kazuo Hosoi, Shali Yu, Chunyan Huang, Haiyan Wei, Gang Chen
Summary: In this study, it was elucidated that BCL-2, as a pro-apoptotic factor, plays a role in As2O3-induced apoptosis in BEAS-2B cells through NF-kappa B and p38 MAPK signaling pathways. The upregulation, nuclear localization, and phosphorylation of BCL-2 during apoptosis were found to be crucial factors in As2O3-induced cell death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Meng Zhang, Pengyu Lu, Fusen Zhao, Xuemei Sun, Wenqi Ma, Jiahui Tang, Chengbo Zhang, Haigang Ji, Xindong Wang
Summary: The aim of this study was to explore the potential mechanism and anti-myocardial fibrosis effects of treatment with Curcumae Rhizoma. It was found that Curcumae Rhizoma significantly reduced myocardial fibrosis and restored cardiac function, potentially by inhibiting the p38 MAPK/NF-kappa B and TGF-beta 1/Smad2/3 pathways. These findings suggest that Curcumae Rhizoma may be a promising therapeutic agent for alleviating myocardial fibrosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin Zhou, Junhong Li, Ludvig J. Backman, Patrik Danielson
Summary: This study investigated the effects of IL-1 beta and TGF beta 1 on corneal stromal cell differentiation. IL-1 beta treatment reduced the keratocyte phenotype, while TGF beta 1 treatment induced differentiation towards myofibroblasts. The crosstalk between IL-1 beta and TGF beta 1 was mediated by the NF-kappa B signaling pathway, with IL-1 beta inhibiting TGF beta 1-induced keratocyte-myofibroblast differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Yanjun Zhang, Chunli Wang, Xiaona Li, Li Yang
Summary: The imbalance in the expression of MMPs and LOXs in SFs caused by mechanical injury and inflammatory response prevents injured ACLs from self-healing. This study found that growth factors and mechanical factors play an important role in regulating the joint-cavity microenvironment.
Article
Biotechnology & Applied Microbiology
Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan, Xiuwei Zhang
Summary: This study found that adiponectin (APN) has significant therapeutic effects on idiopathic pulmonary fibrosis (IPF). APN reduces inflammation and fibrosis in lung tissues, as well as inhibiting collagen fiber accumulation and cell proliferation. These effects may be mediated through the inhibition of the NF-kappa B signaling pathway.
Article
Environmental Sciences
Ahmed G. Abd Elhameed
Summary: The study revealed that the combination of oral aspirin and krill oil could significantly alleviate silica-induced pulmonary injury by reducing inflammatory cell accumulation, decreasing oxidative stress levels, and inhibiting the expression of inflammatory and fibrotic mediators. Additionally, this combination also showed a decrease in hydroxyproline content induced by silica and a clear restoration of lung architecture.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nutrition & Dietetics
Sun-Mi Yun, Young-Min Han, Moon-Young Song, Da-Young Lee, Hyun Su Kim, Seok-Ho Kim, Eun-Hee Kim
Summary: Fibrosis, especially in patients with inflammatory bowel disease, is a problem that needs to be resolved as it affects almost every organ. TGF-beta signaling plays a key role in intestinal fibrosis and its modulation, such as by using Xanthohumol, could be a potential therapy for fibrosis. This study investigated the anti-fibrotic effect of Xanthohumol on TGF-beta 1-induced intestinal fibrosis in primary human intestinal fibroblasts.
Article
Nutrition & Dietetics
Mingchao Zhao, Xiaopeng Song, Hong Chen, Tianwen Ma, Jilang Tang, Xinyu Wang, Yue Yu, Liangyu Lv, Lina Jia, Li Gao
Summary: Through studies in rat models and in vitro experiments, we found that melatonin (MT) has a protective effect on chondrocytes and can alleviate osteoarthritis degeneration. MT can inhibit the expression of inflammatory molecules and matrix metalloproteinases while promoting the expression of chondroprotective proteins. These findings reveal the potential role of MT in the treatment of osteoarthritis.
Article
Allergy
Linda Quatrini, Paola Vacca, Nicola Tumino, Francesca Besi, Anna Laura Di Pace, Francesca Scordamaglia, Stefania Martini, Enrico Munari, Maria Cristina Mingari, Sophie Ugolini, Lorenzo Moretta
Summary: The induction of PD-1 expression on human NK cells in the tumor setting is dependent on the cooperative action of glucocorticoids and cytokines, leading to enhanced mRNA translation and increased PD-1 levels.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carolina Giordano, Giovanni Sabatino, Simona Romano, Giuseppe Maria Della Pepa, Martina Tufano, Quintino Giorgio D'Alessandris, Simone Cottonaro, Marco Gessi, Mario Balducci, Maria Fiammetta Romano, Alessandro Olivi, Simona Gaudino, Cesare Colosimo
Summary: This study evaluated FKBP51s expression in circulating monocytes from 14 GBM patients and found a correlation between PD-L1 expression on monocytes and MRI tumor necrosis score. A significant difference in circulating CD163/monocytes was observed between patients with complete vs. partial surgical removal of the tumor. Post-Stupp therapy, changes in CD163/FKBP51s+ monocytes were observed in patients with different treatment responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Nicola Corcione, Simona Romano, Alberto Morello, Paolo Ferraro, Michele Cimmino, Michele Albanese, Martina Tufano, Daniela Capasso, Salvatore Buonpane, Salvatore Giordano, Martino Pepe, Giuseppe Biondi-Zoccai, Maria Fiammetta Romano, Arturo Giordano
Summary: Thrombocytopenia is common and clinically detrimental after TAVI. Investigating platelet damage in different valve recipients revealed a potential role of the storage solution in inducing platelet injury and stimulating innate immunity. Larger prospective studies are needed to further explore this hypothesis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Martina Tufano, Paolo D'Arrigo, Massimo D'Agostino, Carolina Giordano, Laura Marrone, Elena Cesaro, Maria Fiammetta Romano, Simona Romano
Summary: The study revealed a correlation between PD-L1 expression dynamics in GBM and cyclin-D fluctuation, suggesting FKBP51s might participate in regulating cyclin-D oscillation.
Article
Cell Biology
Martina Tufano, Elena Cesaro, Rosanna Martinelli, Roberto Pacelli, Simona Romano, Maria Fiammetta Romano
Summary: Melanoma cells have multiple mechanisms to evade immune control, with FKBP51 playing a key role in reducing DR5 expression through promoting YY1 repressor activity. Targeting FKBP51 can increase DR5 expression and sensitivity to TRAIL-induced cell death, improving the tumoricidal action of immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Surgery
Maurizio Gentile, Lorenzo Vergara, Vincenzo Schiavone, Giovanni Cestaro, Luigi Sivero
Summary: Bezoar is an undigested substance found in the intestines of humans or animals, often causing constipation and pain. This article reports a case of pumpkin seed bezoars causing abdominal pain, constipation, and rectal problems, which was successfully resolved through manual disimpaction.
FRONTIERS IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Laura Marrone, Massimo D'Agostino, Elena Cesaro, Valeria di Giacomo, Simona Urzini, Maria Fiammetta Romano, Simona Romano
Summary: FKBP51 is expressed in immune cells and acts as a coreceptor for FK506 and rapamycin, which have immunosuppressive effects. However, its role in the adaptive immune response of lymphocytes is not well understood. This study investigated the expression of FKBP51 during lymphocyte activation and found two isoforms, canonical FKBP51 and FKBP51s, that were induced alternately during the proliferative burst. FKBP51s was shown to support Treg development and may have an effect on gene transcription regulation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Martina Tufano, Laura Marrone, Chiara D'Ambrosio, Valeria Di Giacomo, Simona Urzini, Yichuan Xiao, Monica Matuozzo, Andrea Scaloni, Maria Fiammetta Romano, Simona Romano
Summary: FKBP51 is crucial for the survival of cancer cells, especially melanoma. It involved in various signaling pathways and forms a complex with Akt and PHLPP, known for dephosphorylation of Akt. This study focuses on the regulation of Akt activation by canonical and spliced isoforms of FKBP51. The TPR domain of FKBP51 is found to mediate Akt ubiquitination at K63, an important step for Akt activation. Surprisingly, PHLPP does not promote Akt phosphorylation when silenced and even induces Akt phosphorylation when overexpressed. PHLPP stabilizes TRAF6, an E3 ubiquitin ligase, and supports K63-ubiquitination of Akt. The interactome profile of FKBP51 in melanoma cells emphasizes the crucial role of PHLPP in enhancing oncogenic characteristics, particularly cell proliferation.
CELL DEATH & DISEASE
(2023)
Review
Surgery
Stefania Sivero, Nelson M. Maldonato, Alessia Chini, Rosa Maione, Rosa Vitale, Serena Volpe, Saverio Siciliano, Mario Bottone, Luigi Sivero
Summary: A systematic review of international literature was conducted to analyze the effects of autogenic training on cancer patients. After searching through electronic databases, 5 relevant studies were identified, all reporting beneficial effects on mental status and two also reporting an effect on the immune system.
Article
Surgery
Luigi Sivero, Saverio Siciliano, Nicola Gennarelli, Rosa Maione, Serena Volpe, Rosa Vitale, Alessia Chini, Stefania Sivero
Summary: This study evaluated the efficacy, safety, and complication rates of percutaneous endoscopic gastro-jejunostomy (PEG-J) with levodopa/carbidopa intestinal gel in the treatment of patients with Parkinson's disease. The results showed that this technique is safe and effective in relieving symptoms in both the short and long term.
Article
Surgery
Grazia Salerno, Paola Villari, Vincenzo Catalano, Luigi Sivero, Mauro Nelson Maldonato, Mario Bottone, Stefania Sivero
Summary: This research investigated the influence of rehabilitation methods on the perceived quality of life of laryngectomized patients. It was found that patients using electrical or tracheo-esophageal prostheses reported a better quality of life than those with an erythromophonic voice. The results highlight the importance of preoperative counseling.
ANNALI ITALIANI DI CHIRURGIA
(2023)
Article
Surgery
Luigi Sivero, Saverio Siciliano, Alessia Chini, Serena Volpe, Nicola Gennarelli, Grazia Salerno, Stefania Sivero
Summary: In our study, we evaluated a group of patients who underwent total laryngectomy and needed a vocal prosthesis. The use of videoendoscopy was found to be interesting and advantageous in assessing neoplastic relapses and secondary lesions of the esophagus. Psychological evaluations showed that most patients had psychosocial disorders, but voice recovery significantly improved their relationships.
ANNALI ITALIANI DI CHIRURGIA
(2022)
Article
Surgery
Luigi Sivero, Serena Volpe, Maurizio Gentile, Stefania Sivero, Speranza Iovino, Nicola Gennarelli, Alessia Chini, Saverio Siciliano
Summary: This study evaluated the role of narrow band imaging endoscopy in the early detection of infiltration of the colon wall by flat and depressed lesions, and highlighted the potential for treatment with endoscopic mucosal resection. The results showed that narrow band imaging endoscopy is a sensitive, specific, and accurate technique for assessing colon wall infiltration. Endoscopic resection was successful in treating non-polypoid colorectal lesions and early tumors.
ANNALI ITALIANI DI CHIRURGIA
(2022)
Article
Surgery
Luigi Sivero, Mario Bottone, Saverio Siciliano, Serena Volpe, Rosa Maione, Alessia Chini, Matteo Pollastro, Speranza Iovino, Stefania Sivero
Summary: This study evaluates the postoperative follow-up and psychological impact of colostomy on the quality of life of patients with colorectal cancer. The results show that complications such as diversion colitis, stoma stenosis, and stomatitis were detected during endoscopic control. From a psychological perspective, patients experienced body image alteration, loss of sphincter control, embarrassment and shame, impairment of sexuality and social relationships, as well as anxiety, depression, and loneliness.
ANNALI ITALIANI DI CHIRURGIA
(2022)
Article
Surgery
Maurizio Gentile, Giovanni Cestaro, Luigi Sivero
Summary: Hemorrhoids are a common proctological disorder with high incidence and prevalence, affecting individuals' personal and working lives. The fear of SARS-COVID infection has led to delays in hospitalization for surgery, with rubber band ligation (RBL) being proposed as a successful non-surgical treatment option. RBL is cost-effective and commonly used, with a low rate of complications reported in patients with I to III grade hemorrhoids.
ANNALI ITALIANI DI CHIRURGIA
(2021)