Review
Chemistry, Medicinal
Suxing Jin, Yan Guo, Zijian Guo, Xiaoyong Wang
Summary: Monofunctional platinum(II) complexes are a class of non-traditional anticancer agents hopeful to overcome the defects of current platinum drugs, with designs aiming to visualize cellular distribution, reduce side effects, improve tumor selectivity, or inhibit cancer cells through non-DNA targets.
Article
Chemistry, Physical
Santosh Arora, Dinesh Talwar, Monika Chetal, Vimal K. Bhardwaj, Abhishek Dawar, Harsimran Sidhu, Shruti Kashyap, Neena Capalash
Summary: A novel cobalt (III) complex salt [Co(bpy)(2)CO3](center dot)IO4 was synthesized in aqueous medium at room temperature and characterized using various analytical techniques. The complex exhibited significant antibacterial activity against Gram-positive and Gram-negative bacteria, as well as promising anti-cancer potential based on its ability to reduce the viability of HeLa cells in a concentration-dependent manner.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Jasmin Simon, Claudia Horstmann Nee Gruschka, Andreas Mix, Anja Stammler, Jan Oldengott, Hartmut Boegge, Thorsten Glaser
Summary: A family of dinuclear complexes based on 2,7-disubstituted 1,8-naphthalenediol-ligands has been designed to bind covalently to two neighboring phosphate diester groups in the backbone of DNA. The dinuclear Cu-II and Ni-II complexes bind to DNA resulting in the inhibition of DNA synthesis in PCR experiments and in a cytotoxicity that is stronger for human cancer cells than for human stem cells of the same proliferation rate.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Zhonghui Zhang, Guoyuan Du, Guidong Gong, Yuwen Sheng, Xiangyu Lu, Wentao Cai, Fei Wang, Gang Zhao
Summary: In this study, a new organic bimetallic complex with a cross configuration was synthesized, which showed excellent anti-tumor activity by suppressing the viability of tumor cells effectively and possessing lower toxicity in normal cells. The mechanism of action may involve inducing apoptosis in cells to exert anti-proliferation activity.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Oncology
Samah Mutasim Alfadul, Egor M. Matnurov, Alexander E. Varakutin, Maria V. Babak
Summary: Metal complexes are potential alternatives to small organic molecules for cancer treatment. The structure of metal complexes can be easily modified due to the variety of metal oxidation states and geometries. This article aims to discuss their potential as p53-targeting drugs.
Review
Biochemistry & Molecular Biology
Olga Klaudia Szewczyk, Piotr Roszczenko, Robert Czarnomysy, Anna Bielawska, Krzysztof Bielawski
Summary: Nanotechnology shows great potential in advanced cancer therapies, allowing for simultaneous drug administration and immune system engagement. Nanoparticles can locate metastases and deliver medications, effectively reducing tumors with minimal toxicity to healthy tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuewen Sun, Enmao Yin, Yehong Tan, Tao Yang, Dongfan Song, Suxing Jin, Zijian Guo, Xiaoyong Wang
Summary: Platinum-based anticancer drug DCP can effectively induce immunogenic cell death, stimulating the antitumor immune response and increasing cytotoxicity to cancer cells.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Jason Koon-Lam Poon, Zhen Chen, Sammual Yu-Lut Leung, Ming-Yi Leung, Vivian Wing-Wah Yam
Summary: Complex supramolecular tessellations are achieved through directed self-assembly, with key factors including topological transition and side chain phase separation. These findings demonstrate the potential of supramolecular engineering in creating complex self-assembled architectures of soft materials.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Materials Science, Multidisciplinary
Peter A. Ajibade, Athandwe M. Paca, Moganavelli Singh
Summary: We investigated the influence of thermolysis time on the morphological, optical, and anticancer properties of palladium sulfide (PdS) nanoparticles. Our results showed that the palladium sulfide nanoparticles maintained a tetragonal crystalline phase regardless of the thermolysis time. The nanoparticles exhibited spherical shapes with particle sizes ranging from 3.00 to 5.10 nm, and the optical band gaps decreased with increasing thermolysis time. Furthermore, the palladium sulfide nanoparticles showed potential anticancer activity against HeLa cells.
Review
Biochemistry & Molecular Biology
Peiman Norouzi, Maryam Mirmohammadi, Mohammad Hassan Houshdar Tehrani
Summary: This article discusses the importance of peptide therapy in the treatment of cancer. Peptides have advantages such as smaller size, high activity, and low immunogenicity, making them potentially beneficial for cancer treatment as they can form pores in cell membranes and induce necrosis or apoptosis of abnormal cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Mousa Al-Noaimi, Firas F. Awwadi, Iman A. Mansi, Mohammad Sawwan, Bashaer Abu-Irmaileh, Necmi Dege
Summary: Two polymorphs based on a new Pd(II) complex, [Pd(Y)], have been characterized and analyzed using various methods. The formation of these polymorphs is rationalized based on the chirality of the complex. The complex shows higher cytotoxic activity against certain cancer cell lines compared to the ligand and the chemotherapeutic drug doxorubicin.
Article
Chemistry, Multidisciplinary
Sandipan Mukherjee, Avishkar Sawant, Shweta S. Prassanawar, Dulal Panda
Summary: In this study, a copper complex of plumbagin (Cu-PLN) was synthesized and its antiproliferative activities in different cancer cells were investigated. Cu-PLN exhibited stronger inhibitory effects on the proliferation of cancer cells compared to plumbagin. The mechanism of action involved microtubule disassembly, induction of reactive oxygen species, reduction of mitochondrial membrane potential, and DNA damage. The copper complexation of plumbagin shows promise as a potent antitumor agent with stronger antiproliferative activity than the widely used anticancer drug cisplatin.
Article
Chemistry, Multidisciplinary
Sandipan Mukherjee, Avishkar V. Sawant, Shweta S. Prassanawar, Dulal Panda
Summary: We synthesized a copper complex of plumbagin (Cu-PLN) and evaluated its antiproliferative activities in different cancer cells. Cu-PLN showed stronger inhibitory effects on the proliferation of cervical carcinoma, breast cancer, and melanoma cells compared to plumbagin. The mechanism of action of Cu-PLN involved microtubule disassembly, reactive oxygen species generation, mitochondrial membrane potential reduction, and DNA damage. These findings suggest that Cu-PLN has potential as a promising antitumor agent.
Article
Chemistry, Multidisciplinary
M. K. Pal, A. G. Majumdar, K. V. Vivekananda, A. P. Wadawale, M. Subramanian, N. Bhuvanesh, S. Dey
Summary: A series of Pt metallacycles were constructed and their structures and stability were studied. The new Pt complexes showed low antiproliferative activity but high induction of apoptosis and DNA damage.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Alessandro Aliprandi, Remi Rouquette, Luca Pesce, Klaus Wurst, Claudio Perego, Peter Bruggeller, Giovanni M. Pavan, Luisa De Cola
Summary: Self-assembly relies on the ability of smaller entities to arrange into organized systems, with the design of the media playing a crucial role. The media determines the self-assembly pathway and can control the wrapping process of supramolecular homo-aggregates by a different crystal lattice component. This reverse coating process is controlled by the media composition and could lead to the construction of hierarchical supramolecular structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
