Article
Oncology
Alexis Woodward, Gabriela N. F. Faria, Roger G. Harrison
Summary: Identifying a universal biomarker for cancer treatment remains a major challenge. Phosphatidylserine is highly expressed in cancer cells and the vasculature, and the native binding partner ANXA5 can deliver chemotherapies to the tumor microenvironment.
Article
Chemistry, Physical
Anna Mularski, Stine Lauritzen Sonder, Anne Sofie Busk Heitmann, Jesper Nylandsted, Adam Cohen Simonsen
Summary: The study reveals that ANXA4 and ANXA5 colocalize at the damage site of MCF7 cells during repair, with their (1:1) mixture inducing membrane rolling with an intermediate time constant. Unlike the crystal lattices formed by pure annexins, the (1:1) mixture generates a random arrangement of trimers, showing that curvature induction is the functional property of annexin mixtures in PMR rather than crystal formation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Bin Qu, Yeming Han, Ting Liang, Chao Zhang, Guihua Hou, Feng Gao
Summary: A novel peptide, SD01, was designed and tested for its potential in the diagnosis of TNBC. Compared to another peptide YSA, SD01 showed higher affinity, better imaging, and higher tumor accumulation, making it a promising targeting agent for EphA2.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Obstetrics & Gynecology
Xiaojie Wang, Yarui Dai, Jialu Zhang, Xin Li
Summary: This study found that ANXA5 can inhibit proliferation and metastasis of cervical cancer cells by regulating the PI3K/Akt signaling pathway.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Chemistry, Multidisciplinary
Nicole D. Barth, Lorena Mendive-Tapia, Ramon Subiros-Funosas, Ouldouz Ghashghaei, Rodolfo Lavilla, Laura Maiorino, Xue-Yan He, Ian Dransfield, Mikala Egeblad, Marc Vendrell
Summary: The study describes the design and optimization of a fluorescent probe, Apotracker Red, for real-time detection of cancer cell death. The probe exhibits strong fluorogenic behavior, high selectivity, and excellent stability, making it a reliable optical reporter for characterizing the effects of anticancer drugs in cells in vitro and for direct imaging of chemotherapy-induced apoptosis in vivo in mouse models of breast cancer.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Shushan Ge, Jihui Li, Yu Yu, Zhengguo Chen, Yi Yang, Liqing Zhu, Shibiao Sang, Shengming Deng
Summary: Breast cancer is the most frequently occurring cancer globally, with HER2 overexpression affecting prognosis. Molecular imaging technologies can non-invasively, in real time, and quantitatively reflect the expression status of HER2 in tumors, providing a new approach for treatment selection and monitoring treatment response for patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruping Li, Huihui He, Xinling Li, Xiaobin Zheng, Zhijian Li, Hu Zhang, Jiacong Ye, Weiguang Zhang, Chunjing Yu, Guokai Feng, Wei Fan
Summary: In this study, a high-affinity EDB-FN targeted peptide named EDBp was identified and three probes based on EDBp were developed for surgical navigation, radionuclide imaging, and therapy of thyroid cancer. The results from animal experiments and clinical evaluations demonstrated the potential application of these probes in the diagnosis and treatment of thyroid cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Kosei Nakajima, Yoshinori Ino, Chie Naito, Satoshi Nara, Mari Shimasaki, Utako Ishimoto, Toshimitsu Iwasaki, Noriteru Doi, Minoru Esaki, Yoji Kishi, Kazuaki Shimada, Nobuyoshi Hiraoka
Summary: The study investigated the alteration of collagen and gene expression profiles in PDAC tissues after NAT. Effective NAT reduced the expression of type I, III, IV, and V collagen in PDAC tissues. Ephrin-A5 was identified as a crucial ligand in NAT-induced matrix remodeling through CAFs.
BRITISH JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Daniela Miladinova
Summary: Targeting HER2 for imaging and therapy in nuclear medicine involves developing more powerful radiopharmaceuticals. Zirconium-89 is essential for immune PET imaging and can be labeled with anti-HER2 antibodies. Other PET tracers like Cuprum-64 and Galium-68, as well as SPECT radiopharmaceuticals Indium-111 and Technetium-99m, have also been attempted. Nanobodies, affibodies, and minibodies have been developed as smaller molecules with shorter residence times for imaging. Silica nanoparticles conjugated with anti-HER2 antibodies allow targeted delivery of antitumor agents with radioisotopes commonly used for radionuclide therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Engineering, Biomedical
Sung Eun Lee, Chan Mi Lee, Ji Eun Won, Gun-Young Jang, Ju Hyeong Lee, Sang Hyeon Park, Tae Heung Kang, Hee Dong Han, Yeong-Min Park
Summary: This study demonstrates a selective nanocarrier system that enhances cytotoxic T cell immunity against tumor-specific antigens, increases survival rates of immune-activating cells, and reduces tumor mass by decreasing immune-suppressive cells and anti-inflammatory cytokines. Combining the nanocarrier system with other ICIs further amplifies the anticancer immunity of interferon gamma+ (IFN-gamma) CD8+ T cells.
Review
Oncology
Huiling Li, Zhen Liu, Lujie Yuan, Kevin Fan, Yongxue Zhang, Weibo Cai, Xiaoli Lan
Summary: Breast cancer is a common malignant tumor that affects women globally, posing a significant threat to their health. Early detection of breast cancer can greatly improve patient prognosis and survival rates, with radionuclide molecular imaging techniques offering advantages in functional detection. Using radionuclide-labeled compounds for noninvasive visualization of biological processes helps elucidate the metabolic state of breast cancer, while receptor-targeted radionuclide molecular imaging is sensitive and specific for visualizing overexpressed molecular markers in the disease, aiding in early diagnosis and improved patient care. Rapid developments in radionuclide probes are contributing to the diagnosis of breast cancer across various aspects, with promising tools being developed for early detection.
Review
Radiology, Nuclear Medicine & Medical Imaging
V. Mohan, N. M. Bruin, J. B. van de Kamer, J. -J. Sonke, Wouter V. Vogel
Summary: Radiation therapy is effective for treating various cancers, but can lead to toxicity in normal tissues due to dose deposition. Nuclear medicine imaging techniques can measure regional function loss from radiation therapy and establish dose-effect relationships to optimize treatment strategies. Molecular imaging can also help reduce normal tissue toxicity in radionuclide therapy by testing protective strategies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Cell Biology
Celine Gounou, Flora Bouvet, Benjamin Liet, Valerie Prouzet-Mauleon, Lena d'Agata, Etienne Harte, Francoise Argoul, Geraldine Siegfried, Richard Iggo, Abdel-Majid Khatib, Anthony Bouter
Summary: ANXA5 and ANXA6 are crucial components of the membrane repair machinery in MDA-MB-231 cells and are correlated with the invasiveness of breast cancer cells. High expression of ANXA5 and ANXA6 predicts poor prognosis in high-grade lung, gastric, and breast cancers. Genetic inhibition of ANXA5 and ANXA6 in zebrafish significantly reduces tumor cell dissemination.
BIOLOGY OF THE CELL
(2023)
Review
Oncology
Sofia Koustoulidou, Mark W. H. Hoorens, Simone U. Dalm, Shweta Mahajan, Reno Debets, Yann Seimbille, Marion de Jong
Summary: Cancer Associated Fibroblasts (CAFs) are a crucial component of the tumor microenvironment with complex origins and diverse functions, making them an appealing target for novel therapeutic interventions in cancer. Despite some limitations in translating CAF-targeting interventions from research to clinical use, promising developments have been made, particularly in targeting Fibroblast Activation Protein (FAP) on CAFs for improved cancer diagnosis and treatment.
Article
Cell Biology
Chen Su, Yeming Han, Bin Qu, Chao Zhang, Ting Liang, Feng Gao, Guihua Hou
Summary: This study suggests that CD93 in Mφ is a potential novel target for atherosclerotic plaque imaging. Through experimental validation, CD93(hi) and CD93(lo) Mφ, as well as CD93 antibody injection, can specifically target CD93 in atherosclerotic plaques.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)