Article
Materials Science, Multidisciplinary
Ayano Imai, Shunta Takahashi, Sho Furubayashi, Yosuke Mizuno, Masaki Sonoda, Tomoyuki Miyazaki, Eizo Miyashita, Toshinori Fujie
Summary: A flexible thin-film electrode, fabricated using printed electronics, is capable of long-term monitoring and electrical stimulation of the cerebral cortex without causing severe inflammatory reactions. This electrode, with 35 channels, successfully visualized epileptiform activity in a drug-induced epilepsy rat model, showing potential for the management of intractable epilepsy.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Md Eshrat E. Alahi, Yonghong Liu, Zhen Xu, Hao Wang, Tianzhun Wu, Subhas Chandra Mukhopadhyay
Summary: Implantable electrodes have great potential for neural signal recording in various fields, with advancements in micro/nanotechnologies and material science helping to overcome challenges. Electrodes like ECoG allow large-scale signal recording and bi-directional communication between the brain and external electronics, with promising applications in the future.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Miheng Dong, Harold A. Coleman, Mary A. Tonta, Zhiyuan Xiong, Dan Li, Sebastian Thomas, Minsu Liu, James B. Fallon, Helena C. Parkington, John S. Forsythe
Summary: In this study, the authors demonstrated that graphene oxide coating on metal-based neural electrodes could significantly enhance charge storage capacity and reduce impedance without adverse effects on neuronal development. Acute and chronic recordings showed improved signal-to-noise ratio and signal amplitude with the coating.
Article
Multidisciplinary Sciences
Zeinab Jahed, Yang Yang, Ching-Ting Tsai, Ethan P. Foster, Allister F. McGuire, Huaxiao Yang, Aofei Liu, Csaba Forro, Zen Yan, Xin Jiang, Ming-Tao Zhao, Wei Zhang, Xiao Li, Thomas Li, Annalisa Pawlosky, Joseph C. Wu, Bianxiao Cui
Summary: This study develops mechanically robust nanocrown electrodes with high success rates achieved through electroporation, and validates their accurate recording of intracellular action potentials through simultaneous patch clamp recording. The study also demonstrates the ability of nanocrown electrodes to enable prolonged recording of the same cells after sequential addition of drugs. This technological advancement is significant for establishing a screening assay for preclinical evaluation of drug-induced arrhythmogenicity.
NATURE COMMUNICATIONS
(2022)
Review
Clinical Neurology
Wolf -Julian Neumann, Richard M. Koehler, Andrea A. Kuehn
Summary: This review summarizes the experience from invasive neurophysiology experiments in over 500 DBS cases in the last 20 years in a single centre, covering the technical aspects of microelectrode recordings and LFP signals, and discussing current and next-generation developments.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Biophysics
Abhinav Goyal, Steve Goetz, Scott Stanslaski, Yoonbae Oh, Aaron E. Rusheen, Bryan Klassen, Kai Miller, Charles D. Blaha, Kevin E. Bennet, Kendall Lee
Summary: Deep brain stimulation (DBS) is commonly used to treat neurological disorders, but there is a need for a fully-implantable DBS system that can chronically record patient-specific electrophysiological biomarkers to improve therapeutic benefit. The Percept PC is the first FDA-approved device capable of simultaneous recordings and stimulation, with potential applications beyond DBS in understanding normal and abnormal neurophysiology.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Oncology
Diana Cristina Ghinda, Ben Lambert, Junfeng Lu, Ning Jiang, Eve Tsai, Adam Sachs, Jin-Song Wu, Georg Northoff
Summary: The study demonstrated distinct power law exponent features in the tumoral tissue for the first time, potentially providing a novel electrophysiological marker in the future. The significant features observed in the peritumoral tissue of gliomas indicate the area where both the onset of epileptiform activity and the tumor infiltration occur.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Kyeong Jae Lee, Daun Hong, Jae-Won Jang, Kyeong Yeon Lee, Byungwook Park, Joong-Hyun Kim, June Sic Kim, Sohee Kim
Summary: A high-throughput wireless recording system was developed using off-the-shelf components, enabling high-resolution recording of neural signals without restricting subject movement.
IEEE SENSORS JOURNAL
(2023)
Article
Neurosciences
Susumu Setogawa, Ryota Kanda, Shuto Tada, Takuya Hikima, Yoshito Saitoh, Mikiko Ishikawa, Satoshi Nakada, Fumiko Seki, Keigo Hikishima, Hideyuki Matsumoto, Kenji Mizuseki, Osamu Fukayama, Makoto Osanai, Hiroto Sekiguchi, Noriaki Ohkawa
Summary: Characterization of inter-regional interactions in the brain is important for understanding brain function and neurological disease. The development of a flexible micro-electrocorticography device allows large-scale cortical activity examination. This study presents a sheet-shaped 64-channel device that allows access to the mouse temporal cortex and establishes surgical techniques for its implantation. The device successfully records activity in somatosensory and olfactory cortices in awake and anesthetized mice.
Article
Engineering, Electrical & Electronic
Jeongpil Park, Jihye Bong, Yei Hwan Jung, Jack Kegel, Boyuan Liu, Aaron J. Suminski, Sarah K. Brodnick, Hokyung Jang, Zongfu Yu, Justin C. Williams, Zhenqiang Ma
Summary: The study successfully combines optogenetics with electrocorticography, utilizing microscale optoelectronic devices and transparent electrodes to achieve simultaneous modulation and recording of neural activity. The new combined system overcomes the physical constraints on natural behavior and challenges in delivering light, showing potential for widespread research and clinical applications.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
Article
Clinical Neurology
Bryan Howell, Faical Isbaine, Jon T. Willie, Enrico Opri, Robert E. Gross, Coralie De Hemptinne, Philip A. Starr, Cameron C. McIntyre, Svjetlana Miocinovic
Summary: This study evaluated the accuracy of patient-specific estimates of neural pathway activations in the subthalamic region using connectomic modeling of subthalamic DBS. Results showed that good model performance required accurate lead localization, image fusions, and appropriate selection of fiber diameter in the biophysical model. The findings demonstrated that connectomic models of DBS with sufficient anatomical and electrical details can predict recruitment dynamics of white matter, aiding in defining standards for surgical targeting and patient programming applications.
Article
Neurosciences
Scott R. Stanslaski, Michelle A. Case, Jonathon E. Giftakis, Robert S. Raike, Paul H. Stypulkowski
Summary: This study provides an update on the chronic neural sensing performance of a fully implantable bi-directional neural interface system. The results show that the system performed as designed, allowing for chronic stimulation and recording of neural activity for up to 5 years. The study also found stable morphology, amplitude, and latencies of evoked potentials and consistent spectral peaks of local field potentials over time.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Pengfei Zhai, Xiuwei Xuan, Hongji Li, Cuiping Li, Penghai Li, Mingji Li
Summary: The study demonstrates that B and N co-doped vertical graphene (BNVG) electrodes can improve the contact issue of graphene in monitoring scalp electroencephalogram (EEG) signals. By analyzing the effects of different B and N atom contents, the optimal BNVG electrode is determined and successfully applied in an EEG cap for recording EEG signals, which has important implications for clinical and brain-computer interface systems.
Article
Engineering, Biomedical
Yu Huan, Jeffrey P. Gill, Johanna B. Fritzinger, Paras R. Patel, Julianna M. Richie, Elena Della Valle, James D. Weiland, Cynthia A. Chestek, Hillel J. Chiel
Summary: Carbon fiber electrodes (CFEs) show potential for stable intracellular stimulation and recording with good signal-to-noise ratios, allowing for multi-neuron recording simultaneously. Despite lower amplitudes compared to glass microelectrodes, CFEs provide a powerful new technology for studying neural circuit dynamics.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Jessica Centracchio, Antonio Sarno, Daniele Esposito, Emilio Andreozzi, Luigi Pavone, Giancarlo Di Gennaro, Marcello Bartolo, Vincenzo Esposito, Roberta Morace, Sara Casciato, Paolo Bifulco
Summary: This study proposed an automated method based on shape analysis for accurate localization and recognition of ECoG electrodes in CT images of patients with drug-refractory epilepsy, achieving significantly improved performances and high classification accuracy.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2021)
Article
Behavioral Sciences
Shiri Simon, Roy Mukamel
BRAIN AND BEHAVIOR
(2016)
Article
Neurosciences
Roee Gilron, Jonathan Rosenblatt, Oluwasanmi Koyejo, Russell A. Poldrack, Roy Mukamel
Article
Neurosciences
Shiri Simon, Roy Mukamel
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Ori Ossmy, Roy Mukamel
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Neurosciences
Nadav Aridan, Ori Ossmy, Batel Buaron, Daniel Reznik, Roy Mukamel
Article
Neurosciences
Ori Ossmy, Roy Mukamel
Review
Neurosciences
Ori Ossmy, Roy Mukamel
Article
Behavioral Sciences
Daniel Reznik, Shiri Simon, Roy Mukamel
Article
Multidisciplinary Sciences
Ori Ossmy, Roy Mukamel
Article
Neurosciences
Matan Mazor, Noam Mazor, Roy Mukamel
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Review
Behavioral Sciences
Daniel Reznik, Roy Mukamel
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Article
Neurosciences
Batel Buaron, Daniel Reznik, Ro'ee Gilron, Roy Mukamel
Article
Neurosciences
Yair Lakertz, Ori Ossmy, Naama Friedmann, Roy Mukamel, Itzhak Fried
Summary: The study found that single-cell responses to phonemes are governed by manner-of-articulation features and organized according to sonority. It also showed that phonemes that were perceptually similar had similar neural responses.
Article
Biochemistry & Molecular Biology
Ori Ossmy, Brianna E. Kaplan, Danyang Han, Melody Xu, Catherine Bianco, Roy Mukamel, Karen E. Adolph
Summary: Planning multi-step actions is crucial for survival and a sign of intelligence. Previous research used a top-down approach, while this study takes a bottom-up approach to examine the developmental changes in the real-time interaction between perceptual, neural, and motor components of action planning.
Article
Rehabilitation
Ori Ossmy, Lihi Mansano, Silvi Frenkel-Toledo, Evgeny Kagan, Shiri Koren, Roee Gilron, Daniel Reznik, Nachum Soroker, Roy Mukamel
Summary: This study aimed to expand previous findings in healthy subjects to examine the utility of a novel virtual-reality training tool in neuro-rehabilitation. The results showed that training led to behavioral gains and enhanced brain activation and functional connectivity.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2022)