Article
Immunology
Fan Mao, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Jingchen Song, Shiwei Fu, Zhiming Xiang, Shu Xiao, Yongbo Bao, Ziniu Yu, Yang Zhang
Summary: This study reveals the regulatory mechanisms of the Hippo pathway in immune responses of Crassostrea hongkongensis hemocytes, highlighting its importance in maintaining immune homeostasis and orchestrating hemocytic functions. It also demonstrates the divergence of the Hippo pathway's roles in marine invertebrate immunity from mammalian observations, indicating the need for further comparative studies across species.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qiujiao Yang, Jianhang Guo, Hairuo Zeng, Lahong Xu, Jiao Xue, Shi Xiao, Jian-Feng Li
Summary: CDG1 functions as a negative regulator in Arabidopsis, negatively regulating flg22- and chitin-triggered immunity by promoting FLS2 and CERK1 degradation. Additionally, CDG1 is partially required for AvrRpm1-induced RIN4 phosphorylation.
Article
Immunology
Floriana Mulas, Xu Wang, Shanshan Song, Gopala Nishanth, Wenjing Yi, Anna Brunn, Pia-Katharina Larsen, Berend Isermann, Ulrich Kalinke, Antonio Barragan, Michael Naumann, Martina Deckert, Dirk Schlueter
Summary: OTUB1 is identified as a potent novel regulator of DCs during infectious and inflammatory diseases. It promotes NF-kappa B activity, regulates cytokine production, and impacts the response to pathogens.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yi Guo, Xia-Nan Zhang, Shan Su, Zi-Lun Ruan, Ming-Ming Hu, Hong-Bing Shu
Summary: Upon viral infection, the levels of beta-adrenergic hormones and their receptors decrease, inhibiting the innate antiviral response. Increased levels of beta-adrenergic hormones activate PKA kinase, which phosphorylates MITA and VISA, suppressing the innate immune response to DNA and RNA viruses. These findings provide insights into the regulatory mechanisms of innate antiviral responses and the increased susceptibility to viral infection in stressful situations.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Microbiology
Leah J. Radeke, Michael A. Herman
Summary: Microbiomes establish close functional associations with hosts, with studies focusing on bacterial interactions with Caenorhabditis elegans and exploring the composition of the native microbiome to integrate into research on innate immunity and pathogenesis.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Patrick Haider, Julia B. Kral-Pointner, Manuel Salzmann, Florian Moik, Sonja Bleichert, Waltraud C. Schrottmaier, Christoph Kaun, Mira Brekalo, Michael B. Fischer, Walter S. Speidl, Christian Hengstenberg, Bruno K. Podesser, Kurt Huber, Ingrid Pabinger, Sylvia Knapp, Frank Brombacher, Christine Brostjan, Cihan Ay, Johann Wojta, Philipp J. Hohensinner
Summary: IL-4R alpha plays a homeostatic role in regulating the lifespan of monocytes, and its absence leads to a reduction in monocyte numbers and affects the occurrence of inflammatory responses.
Review
Allergy
Timothy N. Perkins, Mason L. Donnell, Tim D. Oury
Summary: Asthma affects nearly 400 million people worldwide, with the majority of patients exhibiting a type 2-high phenotype and severe asthma often being associated with a type 2-low phenotype. The receptor for advanced glycation endproducts (RAGE) plays a significant role in asthma pathogenesis and allergic airway disease, especially in severe neutrophilic asthma.
Review
Immunology
Andrea M. Darby, Brian P. Lazzaro
Summary: Immune response requires energy and nutrients, and insulin signaling plays a crucial role in regulating metabolism and overall homeostasis. Studies show interactions between host immune activity and insulin signaling, with effects varying depending on the pathogen, infection route, and host nutritional status.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ioannis Eleftherianos, Ghada Tafesh-Edwards, Amr Mohamed
Summary: Recent studies have shown that insect tissues and organs play a crucial role in the natural infection routes of parasites and microbial pathogens. This article summarizes the different types of parasites that infect insects through distinct routes and examines the relationship between infection routes and insect immune response. The findings suggest that understanding the association between infection routes and insect host defense can help in designing strategies for managing agricultural pests and disease vectors.
IMMUNOLOGY LETTERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
D. Wu, Y. Weng, Y. Feng, B. Liang, H. Wang, L. Li, Z. Wang
Summary: In periodontitis, Trem1 regulates polarization of M1 macrophages through the STAT3/HIF-1α signaling pathway. Studies suggest that targeting Trem1 could be a potential strategy for the treatment of periodontitis by modulating macrophage polarization.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yu-Lin Yang, Li -Bo Cao, Wen-Rui He, Li Zhong, Yi Guo, Qing Yang, Hong -Bing Shu, Ming-Ming Hu
Summary: The current understanding of nucleic acid-mediated innate immunity is that the binding of intracellular sensors to nucleic acids is enough to activate them. However, this study reveals that the endocytosis of viruses or foreign DNA provides a priming signal for the activation of the DNA sensor cGAS in the innate immune response. This finding demonstrates that the activation of cGAS following endocytosis requires tyrosine phosphorylation mediated by the V-ATPase-SYK pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Shangran Zhang, Runan Zheng, Yanhong Pan, Hongbin Sun
Summary: The stimulator of interferon genes (STING) is a critical protein that activates the immune system and participates in the inflammatory response. It can modulate the inflammation-preferred translation program or induce the secretion of type I interferons and proinflammatory factors through different pathways. This review summarizes the potential value of STING inhibitors in preventing and treating infectious diseases, psoriasis, systemic lupus erythematosus, non-alcoholic fatty liver disease, and other inflammatory and autoimmune diseases, based on the structure, location, function, genotype, and regulatory mechanism of STING.
Article
Agronomy
Yulong Wang, Qiumei Zhou, Hanghang Zhang, Li Qin, Bo Huang
Summary: Entomopathogenic fungi have developed strategies to overcome insect immune defenses, while insects have defense mechanisms against fungal infection. This study identified differences in the immune response of Plutella xylostella to different Beauveria bassiana infections at 48 hours, revealing genes related to innate immunity.
PEST MANAGEMENT SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Aleksandra Kusiak, Gareth Brady
Summary: The human innate immune response can be activated by various stimuli, such as PAMPs and DAMPs. These stimuli trigger intracellular signaling pathways that activate transcription factors from the NF-kappa B and IRF families, which play crucial roles in inflammation and antiviral response.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Plant Sciences
Xiaoxiao Liu, Li Wan
Summary: Plant NLR proteins play a crucial role in providing immunity and inducing cell death. Sensor NLRs directly or indirectly recognize pathogen effector proteins to initiate immune signaling, while helper NLRs function downstream of sensor NLRs in transmitting immune signals. Recent breakthrough studies on the structures and functions of plant NLR proteins have significantly advanced our understanding of NLR biology.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Plant Sciences
Ameth N. Garrido, Esther Supijono, Peter Boshara, Scott J. Douglas, Patti E. Stronghill, Baohua Li, Eiji Nambara, Daniel J. Kliebenstein, C. Daniel Riggs
Review
Plant Sciences
Matthias Erb, Daniel J. Kliebenstein
Article
Biology
Ella Katz, Jia-Jie Li, Benjamin Jaegle, Haim Ashkenazy, Shawn R. Abrahams, Clement Bagaza, Samuel Holden, Chris J. Pires, Ruthie Angelovici, Daniel J. Kliebenstein
Summary: This study measured the variation in specialized metabolites across a population of 797 natural Arabidopsis thaliana accessions and found that geography, environmental parameters, demography, and different genetic processes all influence specific chemotypes and their distribution. It revealed that causal loci in specialized metabolism contain frequent independently generated alleles, suggesting potential within-species convergence and providing a new perspective on the complexity of selective forces and mechanisms shaping allelic variation.
Article
Biochemistry & Molecular Biology
Michelle Tang, Baohua Li, Xue Zhou, Tayah Bolt, Jia Jie Li, Neiman Cruz, Allison Gaudinier, Richard Ngo, Caitlin Clark-Wiest, Daniel J. Kliebenstein, Siobhan M. Brady
Summary: Plant metabolism is more complex than individual microbes, with reactions shifting based on internal and external cues. Research suggests that the design principles of plant metabolism are distinct from microbes, primarily coordinated through transcriptional regulation.
MOLECULAR SYSTEMS BIOLOGY
(2021)
Article
Plant Sciences
Kevin A. Ruiz, Julie M. Pelletier, Yuchi Wang, Min Jun Feng, Jacqueline S. Behr, Thai Q. Dao, Baohua Li, Daniel Kliebenstein, John J. Harada, Pablo D. Jenik
Summary: This study reveals that neither ASIL1 nor ASIL2 play a role in regulating maturation during any stage of plant development. Instead, these genes may be involved in responses to specific biotic and abiotic stresses during the vegetative phase.
Editorial Material
Biochemistry & Molecular Biology
Roger W. Innes, Yangnan Gu, Dan Kliebenstein, Dorothea Tholl
Article
Multidisciplinary Sciences
Matthew A. Barbour, Daniel J. Kliebenstein, Jordi Bascompte
Summary: This study reveals that genes of one species can affect the persistence of interacting species in an ecological community. The experiment shows that plant defense genes can promote coexistence by increasing plant growth rate, leading to higher intrinsic growth rates of species across multiple trophic levels.
Review
Biochemistry & Molecular Biology
Anna Jo Muhich, Amanda Agosto-Ramos, Daniel J. Kliebenstein
Summary: This review assesses the potential and limitations of using multi-omics tools to identify specialized metabolic pathways in plants, as well as the use of these enzymes in synthetic biology and crop engineering. Further research investment is needed to enhance the successful application of synthetic biology in exploiting diverse specialized metabolic pathways.
EMERGING TOPICS IN LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ella Katz, Anna Knapp, Mariele Lensink, Caroline Kaley Keller, Jordan Stefani, Jia-Jie Li, Emily Shane, Kaelyn Tuermer-Lee, Arnold J. Bloom, Daniel J. Kliebenstein
Summary: This study investigated the natural genetic variation in nitrogen use in plants by growing a large population of Arabidopsis thaliana genotypes under different nitrogen sources. The results showed a wide range of nitrogen responses associated with different genes and traits. Moreover, unique nitrogen responses, such as preference for ammonium or nitrate, were found to be generated by combinations of loci rather than single large-effect loci.
Editorial Material
Plant Sciences
Daniel J. Kliebenstein
Summary: Recent advances have led to the discovery of specialized metabolite pathways, but our understanding of their regulation lags behind. There is a misconception that these pathways are relatively simple, controlled by a few transcription factors, and the compounds are non-regulatory end-products. However, studies on model specialized metabolites suggest that they are integrated into the plants' core metabolic and developmental pathways, controlled by an extended compendium of transcription factors, and have regulatory connections with the plants signaling machinery. This review focuses on the glucosinolate pathway in Brassicales to illustrate these concepts and highlights the need for the broader community to reconsider the integration of specialized metabolism into the regulatory network of their study species.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Genetics & Heredity
Parvathy Krishnan, Celine Caseys, Nik Soltis, Wei Zhang, Meike Burow, Daniel J. Kliebenstein
Summary: The bidirectional flow of information between host and pathogen is influenced by their genetics. Co-transcriptomic studies have been used to understand this flow, but the plasticity of the co-transcriptome in response to genetic variation is unclear. In this study, using natural genetic variation in the pathogen Botrytis cinerea and genetic variation abolishing defense signaling pathways in the host Arabidopsis thaliana, we found that pathogen genetics have a greater impact on the co-transcriptome. Genome-wide association mapping revealed that the pathogen modulates plasticity in response to the host through trans-expression quantitative trait loci (eQTL) hotspots.
Correction
Multidisciplinary Sciences
J. Grey Monroe, Thanvi Srikant, Pablo Carbonell-Bejerano, Claude Becker, Mariele Lensink, Moises Exposito-Alonso, Marie Klein, Julia Hildebrandt, Manuela Neumann, Daniel Kliebenstein, Mao-Lun Weng, Eric Imbert, Jon Agren, Matthew T. Rutter, Charles B. Fenster, Detlef Weigel
Article
Plant Sciences
Sunil K. Kenchanmane Raju, Mariele Lensink, Daniel J. Kliebenstein, Chad Niederhuth, Grey Monroe
Summary: This study investigates the relationship between gene expression, epigenome, and polymorphism in gene duplicates in Arabidopsis thaliana. Transposon-like methylated gene copies show higher polymorphism frequencies, while gene-body methylated gene copies show lower polymorphism frequencies. This relationship may disrupt equilibrium states and facilitate the evolution of novel gene functions in duplicate paralogs.
Article
Plant Sciences
Ritu Singh, Celine Caseys, Daniel J. Kliebenstein
Summary: Botrytis cinerea is a necrotrophic fungal pathogen that attacks a wide range of plants. It exhibits extensive genetic diversity and employs various genetic and molecular mechanisms to attack its hosts. Strategies to combat B. cinerea include cultural practices, chemical and biological controls, and the use of appropriate crop varieties.
MOLECULAR PLANT PATHOLOGY
(2023)
Article
Plant Sciences
Sunil K. Kenchanmane Raju, Mariele Lensink, Daniel J. Kliebenstein, Chad Niederhuth, Grey Monroe
Summary: The study investigates the relationship between epigenome-associated polymorphism rates and the evolution of gene duplicates in Arabidopsis thaliana. The findings suggest that transcriptionally repressed gene duplicates exhibit higher polymorphism rates and faster evolution, while actively expressed gene duplicates show lower polymorphism rates. The epigenome-mediated polymorphism rate variation may facilitate the evolution of duplicate paralogs.