Article
Peripheral Vascular Disease
Fadi E. Pulous, Jamie C. Carnevale, Zaki Al-Yafeai, Brenna H. Pearson, Jamie A. G. Hamilton, Curtis J. Henry, A. Wayne Orr, Brian G. Petrich
Summary: Integrin activation is essential for key blood cell functions and contributes to postnatal angiogenesis. While endothelial talin1 is indispensable for proper vascular development, inhibiting EC pan-integrin activation may be an effective approach to selectively target tumor blood vessel growth with marked defects in tumor growth and angiogenesis.
Article
Endocrinology & Metabolism
Kavitha Godugu, Shaker A. Mousa, Gennadi V. Glinsky, Hung-Yun Lin, Paul J. Davis
Summary: Apoptosis can be induced in cancer cells and tumor xenografts by tetraiodothyroacetic acid (tetrac) or chemically modified forms of tetrac. Tetrac-based anticancer agents have pro-apoptotic effects through multiple pathways and differential gene expression, and may control the recognition system for apoptotic debris on the cell surface.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lijun Zhong, Lin Tang, Xiaoxia He
Summary: It has been discovered that ANGPTL3 plays an oncogenic role in several types of human malignancies. This study found that ANGPTL3 is highly expressed in cervical cancer cells and silencing ANGPTL3 can inhibit cell proliferation, migration, invasion, and angiogenesis. The inhibitory effect of ANGPTL3 can be offset by upregulating the expression of alpha v beta 3, which also promotes blood vessel formation and the secretion of VEGF and VEGFR2 in cervical cancer cells.
Letter
Peripheral Vascular Disease
Yara Onetti, Roland E. Kaelin, Bettina Pitter, Mengzhuo Hou, Victor Arribas, Rainer Glass, Eloi Montanez
Summary: Endothelial alpha-pv is necessary for tumor angiogenesis and progression. Using an inducible knockout approach, researchers found that loss of endothelial alpha-pv reduces vessel density and vascular complexity in the pathological neo-vasculature of brain tumor-bearing mice. This reduction in tumor vascularization is associated with increased tumor cell apoptosis and decreased tumor volume.
Review
Physiology
Paul J. Davis, Shaker A. Mousa, Hung-Yun Lin
Summary: The integrin alpha v beta 3 receptor for thyroid hormone plays a crucial role in cancer and endothelial cells by regulating cell division, tumor defense mechanisms, angiogenesis, and supporting metastasis, radioresistance, and chemoresistance. T4 and tetrac are the main regulators, involved in signaling pathways and gene expression related to these cell processes.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Oncology
Guixi Zheng, Hakim Bouamar, Matyas Cserhati, Carla R. Zeballos, Isha Mehta, Habil Zare, Larry Broome, Ruolei Hu, Zhao Lai, Yidong Chen, Francis E. Sharkey, Meenakshi Rani, Glenn A. Halff, Francisco G. Cigarroa, Lu-Zhe Sun
Summary: The study found that ITGA6 is upregulated in HCC tumors and has a malignant promoting role in HCC cells through integrin alpha 6 beta 4 complex. Thus, integrin alpha 6 beta 4 may be a therapeutic target for treating HCC patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Ewa Brzozowska, Sameer Deshmukh
Summary: Integrins are crucial for cell adhesion, migration, and positioning. Studies have shown that the expression levels of Integrin αVβ6 are closely related to malignant diseases and patient prognosis. It plays a significant role in cancer progression and the activation of transforming growth factor β(TGF-β). While essential for normal function in healthy individuals, it can also be a target for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kavitha Godugu, Mehdi Rajabi, Shaker A. Mousa
Summary: In this study, we compared the binding affinity and anticancer activities of different compounds targeting integrin alpha v beta 3. The results showed that the three thyrointegrin alpha v beta 3 antagonists exhibited optimal therapeutic efficacy against U87 or primary glioblastoma cells. Biological studies indicated that the size of the PEG linker or the presence of mono-TAT or bi-TAT did not significantly affect their alpha v beta 3 binding affinity, anti-angiogenesis, or overall anti-cancer efficacy.
Article
Biochemistry & Molecular Biology
Gennadi Glinsky, Kavitha Godugu, Thangirala Sudha, Mehdi Rajabi, Sridar Chittur, Aleck A. Hercbergs, Shaker A. Mousa, Paul J. Davis
Summary: Chemically modified forms of Tetrac exert anticancer activity in tumor cells by modulating gene expression via specific hormone receptors, P-bi-TAT downregulates a large number of genes involved in electron transport and oxidative phosphorylation in human cancer cells through acting at alpha v beta 3 integrin.
Article
Medicine, Research & Experimental
Wei-Xia Peng, Pei-Xiang He, Li-Jun Liu, Ting Zhu, Ya-Qin Zhong, Lin Xiang, Ke Peng, Jing-Jin Yang, Guang-Da Xiang
Summary: The study found that the long non-coding RNA GAS5 plays a crucial role in wound healing in diabetic foot ulcers (DFUs) by accelerating wound healing through activating the HIF1A/VEGF pathway. GAS5 interacts with TAF15 to facilitate the expression of HIF1A, contributing to its functions in DFUs.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Marius Kemper, Alina Schiecke, Hanna Maar, Sergey Nikulin, Andrey Poloznikov, Vladimir Galatenko, Michael Tachezy, Florian Gebauer, Tobias Lange, Kristoffer Riecken, Alexander Tonevitsky, Achim Aigner, Jakob Izbicki, Udo Schumacher, Daniel Wicklein
Summary: The knockdown of ITGAV in PDA cells significantly reduces primary tumor growth, peritoneal carcinomatosis, and spontaneous pulmonary metastasis. ITGAV activates latent TGF-beta and drives epithelial-mesenchymal transition. Combined depletion of ITGAV on tumor cells and E- and P-selectins in the tumor-host almost abolishes intraperitoneal spread.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Koji Osuka, Yusuke Ohmichi, Mika Ohmichi, Satoru Honma, Chiharu Suzuki, Masahiro Aoyama, Kenichiro Iwami, Yasuo Watanabe, Shigeru Miyachi
Summary: A chronic subdural hematoma (CSDH) is an inflammatory and angiogenic disease, in which the N-terminal half of osteopontin (OPN) plays a critical role in neovascularization through integrins alpha 9 and beta 1. The concentration of the N-terminal half of OPN in CSDH fluid is significantly higher than in serum, and its promotion of CSDHs is confirmed by the presence of integrins alpha 9 and beta 1, FAK, and paxillin in the endothelial cells of vessels within the CSDH outer membrane.
Review
Cell Biology
Angelika Mojzisch, Maria A. Brehm
Summary: Von Willebrand factor (VWF) is synthesized exclusively in endothelial cells and megakaryocytes, and plays multiple roles in cellular processes such as angiogenesis, leukocyte adhesion, and tumor cell metastasis. Its dysregulation can lead to various pathophysiological consequences.
Article
Environmental Sciences
Zhiwen Zheng, Abuduliaizezi Halifu, Juan Ma, Leyi Liu, Qingfeng Fu, Bocun Yi, E. Du, Dawei Tian, Yong Xu, Zhihong Zhang, Jianqiang Zhu
Summary: With the increasing production and use of graphene oxide (GO), its environmental health and safety (EHS) risks have become a global concern. Previous studies mainly focused on the direct toxic dose of GO, which could not reflect the realistic environmental exposure to GO with a low dose. This study found that low-dose GO can promote tumor cell proliferation and that the lateral size of GO does not affect its promoting effect. Mechanistic investigation revealed that low-dose GO treatment activates the PI3K/AKT/mTOR signaling pathway and promotes mitotic progression.
ENVIRONMENTAL POLLUTION
(2023)
Review
Endocrinology & Metabolism
Shaker A. Mousa, Aleck Hercbergs, Hung-Yun Lin, Kelly A. Keating, Paul J. Davis
Summary: The thyroid hormone receptor on integrin alpha v beta 3 mediates the stimulatory effects of T4 on cancer cell proliferation, angiogenesis, and platelet coagulation. The pro-thrombotic activity of T4 on platelets may support cancer-linked blood clotting and contribute to tumor cell metastasis. Studies have shown that T4 and its derivative tetraiodothyroacetic acid (tetrac) modulate gene expression in thyroid cancer cells, with potential implications for cancer treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Applied
Mohamed Nadjib Boukhatem, Mohamed Amine Ferhat, Mehdi Rajabi, Shaker A. Mousa
Summary: The extraction of lemongrass essential oil using large quantities of solvents has environmental concerns. Solvent-Free Microwave Extraction (SFME) is a promising and greener alternative method, providing faster extraction and higher citral content.
NATURAL PRODUCT RESEARCH
(2022)
Article
Hematology
Osheiza Abdulmalik, Noureldien H. E. Darwish, Vandhana Muralidharan-Chari, Maii Abu Taleb, Shaker A. Mousa
Summary: Sickle cell disease is a genetic disease that causes abnormal blood cells. A new heparin derivative, S-NACH, has been found to directly interfere with HbS and reduce red blood cell deformation, making it a promising candidate for treating sickle cell disease.
Article
Nanoscience & Nanotechnology
Mahmoud H. Teaima, Noha M. Badawi, Dalia A. Attia, Mohamed A. El-Nabarawi, Mohey M. Elmazar, Shaker A. Mousa
Summary: The study aimed to evaluate the anticancer effect of an optimized pomegranate extract loaded solid lipid nanoparticles (PE-SLNs) formula incorporated in a transdermal emulgel. Both ex vivo and in vivo studies showed significant anticancer effects of the formulated emulgel on mice skin bearing solid tumors.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Ramy Ashry, Mahmoud Elhussiny, Hussein Abdellatif, Osama Elkashty, Hassan A. Abdel-Ghaffar, Essam T. Gaballa, Shaker A. Mousa
Summary: EGCG exhibits prominent apoptotic potential on laryngeal cancer stem cells, while HNK mainly induces higher cytotoxic effects on parental cells through necrosis induction. EGCG more potently suppresses Notch signaling pathway genes, while HNK outperforms EGCG in downregulating beta-catenin and Sonic Hedgehog signaling pathway genes.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Steve Harakeh, Yousef Qari, Hanaa Tashkandi, Mohammed Almuhayawi, Saber H. Saber, Emad Aljahdali, Nagla El-Shitany, Soad Shaker, Filipa Lucas, Turki Alamri, Soad Al-Jaouni, Shaker Mousa
Summary: This study evaluated the protective effects of a novel nanoparticle encapsulating thymoquinone (THY) against cisplatin (CISP)-induced nephrotoxicity. The results showed that NP THY effectively prevented kidney toxicity, improved kidney function and pathology. It also ameliorated oxidative stress conditions and reduced inflammation induced by CISP in the kidney tissue.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Cell Biology
Mona M. Ali, Marwa A. Ramadan, Nirvina A. Ghazawy, Amira Afify, Shaker A. Mousa
Summary: This study aims to investigate the toxic and photochemical effects of silver nanoparticles (AgNPs) on Sarcophaga argyrostoma larvae. The results showed that AgNPs caused ultrastructural and morphological changes in the larvae's external cuticle, and had a significant impact on DNA damage, indicating their toxicity.
Retraction
Nanoscience & Nanotechnology
A. M. Abou-El-Naga, G. Mutawa, I. M. El-Sherbiny, S. A. Mousa
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Steve Harakeh, Mohammed S. Almuhayawi, Isaac O. Akefe, Saber H. Saber, Soad K. Al Jaouni, Torki Alzughaibi, Yousef Almehmadi, Soad Shaker Ali, Dhruba J. Bharali, Shaker Mousa
Summary: Pomegranate nanoparticles can effectively ameliorate cisplatin-induced nephrotoxicity without compromising its antitumor efficacy.
Article
Endocrinology & Metabolism
Kavitha Godugu, Shaker A. Mousa, Gennadi V. Glinsky, Hung-Yun Lin, Paul J. Davis
Summary: Apoptosis can be induced in cancer cells and tumor xenografts by tetraiodothyroacetic acid (tetrac) or chemically modified forms of tetrac. Tetrac-based anticancer agents have pro-apoptotic effects through multiple pathways and differential gene expression, and may control the recognition system for apoptotic debris on the cell surface.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S. Mousa, Kavitha Godugu, Murat Yalcin, Shaker A. Mousa
Retraction
Chemistry, Medicinal
E. A. Mohamad, A. A. Aly, A. A. Khalaf
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Steve Harakeh, Saber Hassan Saber, Nagla El-Shitany, Soad S. Ali, Turki Alamri, Mohammed W. Al-Rabia, Addisu Demeke Teklemariam, Kawther A. Zaher, Zeina W. Sharawi, Shafiul Haque, Manal Naseeb, Eram A. Albajri, Shaker Mousa
Summary: This study found that nanoformulations of ellagic acid combined with metformin effectively improved renal function and reduced kidney damage in rats with type II diabetes. Additionally, this treatment led to a decrease in blood glucose levels, decreased lipid peroxidation, and reduced inflammation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Correction
Biochemistry & Molecular Biology
Thikryat Neamatallah, Nagla El-Shitany, Aymn Abbas, Basma G. Eid, Steve Harakeh, Soad Ali, Shaker Mousa
Article
Biotechnology & Applied Microbiology
Thangirala Sudha, Taher A. Salaheldin, Noureldien He Darwish, Shaker A. Mousa
Summary: By synthesizing nanoformulations, the stability of EGCG in green tea extract can be enhanced, and the anticancer and antiangiogenic activity can be improved. Nano-EGCG formulations exhibit better suppression of melanoma growth.
Article
Chemistry, Multidisciplinary
Kholoud K. Arafa, Mohamed A. Hamzawy, Shaker A. Mousa, Ibrahim M. El-Sherbiny
Summary: This study presents the rational designing of mitochondria-targeted core-shell polymeric nanoparticles for efficient delivery of doxorubicin to hepatic carcinoma mitochondria, showing promising results in inducing apoptotic cell death and cell cycle arrest.